To observe the effect of serious illness, surgical trauma, body weight, and clofibrate on serum lipids, the serum levels of cholesterol and triglyceride with lipoprotein patterns by electrophoresis on cellulose acetate membrane were studied in 30 normal persons, 18 patients with coronary heart disease, 26 patients with cerebral thrombosis, and 7 surgical patients. The results obtained were as follows; 1. The values of serum cholesterol and triglyceride in cerebral thrombosis and coronary heart disease were markedly higher than those of control, and the optic dinsities of each serum lipoprotein fractions were also increased significantly. 2. Serum lipoprotein type IIa and IIb were more frequently observed than type IV in cerebral thrombosis and coronary heart disease. 3. The change of serum cholesterol and triglyceride related moderately to relative body weight in normal persons. 4. The decrease in serum cholesterol occured on the 1st day following surgery, and recovered to 97.8% of the preoperation level on the 7th day. The serum triglyceride started to increase on the 3rd day following surgery, and reached to 115.1% of the preoperation level on the 7th day. 5. After attack of cerebrovascular accident the serum cholesterol and triglyceride level increased slowly to the 122.1% and 133.1% of the each lst day level on the 7th day. 6. The serum lipid lowering effect of clofibrate was most conspicuous in the hypertriglyceridemic patients, especially during lst and 2nd week after medication, and mixed hyperlipidemic patients responded moderately. But pure hypercholesterolemic patients resisted completely. The optic densities of each serum lipoprotein fraction were also decreased in drug responded groups.
Body Weight ; Cellulose ; Cholesterol ; Clofibrate ; Coronary Disease ; Electrophoresis ; Humans ; Intracranial Thrombosis ; Lipoproteins ; Membranes ; Stroke ; Triglycerides

A particular problem associated with osseointegrated implants is the fact that the implants lack a periodontal ligament. Thereby, marginal inflammation around an implant may cause more serious bone loss than does marginal inflammation around teeth with a periodontal ligament. In addition, osseointegrated implants are ankylosed and do not haute the same mobility as natural teeth with a periodontal ligament. Implants with a periodontal ligament would eliminate these problems. In order to explore the possibility of producing a periodontal ligament around titanium dental implants, a study of the attachment of cultured periodontal ligament cells to titanium was carried out. Periodontal ligament cells obtained from premolar teeth of individuals undergoing tooth extraction for orthodontic reasons were cultured on titanium-coated epon blocks. Sections of the blocks were cut perpendicular to the surface of the cell layer. Transmission electron microscopy of the periodntal ligament cells/titanium interface showed that there was no evidence of attachment at the cultured periodontal ligament cells titanium interface. The microfilaments, commonly located adjacent to the titanium surface, run mostly parallel to the titanium surface. The study showed that cultured periodontal ligament cells did not create an attachment structure on a titanium surface similar to that of natural teeth.
Actin Cytoskeleton ; Bicuspid ; Dental Implants ; Inflammation ; Ligaments ; Microscopy, Electron, Transmission ; Periodontal Ligament* ; Titanium* ; Tooth ; Tooth Extraction

One hundred and seven cases of coronary heart disease were clinically studied at Seoul National University Hospital from September 1967 to August 1971 and following results were obtained. 1. The total cases were composed with 70 cases of myocardial infarction (46 cases of acute type and 24 cases of old type), 26 cases of angina pectoris and 11 cases of coronary insufficiency. 2. The ratio of male to female was 3.5:1, and over two-thirds of patients were sixth and seventh decade in ages. 3. As the underlying diseases, hypertension was found in 38.3% of the cases, and diabetes mellitus in 10.3%. 4. Among the various symptoms, precordial pain was a most common and characteristic, which was noted in 81.1% of the cases. Pain was radiated to the left arm and/or left shoulder in 45.2% of the cases. 5. In 57.2% of the cases, serum cholesterol was more than 200mg%. 6. The ratio between anterior and posterior wall infarction on electrocardiogram was about 3.5:1. 7. Left ventricular hypertrophy was the most frequently noted finding, and sinus tachycardia, low voltage, ventricular premature beat, myocardial ischemia, and others were also observed in some cases. 8. Mortality rate was 8.4%, and the major causes of death were cardiogenic shock and ventricular fibrillation.
Angina Pectoris ; Arm ; Cardiac Complexes, Premature ; Cause of Death ; Cholesterol ; Coronary Disease* ; Diabetes Mellitus ; Electrocardiography ; Female ; Humans ; Hypertension ; Hypertrophy, Left Ventricular ; Infarction ; Male ; Mortality ; Myocardial Infarction ; Myocardial Ischemia ; Seoul ; Shock, Cardiogenic ; Shoulder ; Tachycardia, Sinus ; Ventricular Fibrillation

The serum cholesterol and triglyceride levels were measured and the lipoprotein patterns by electrophoresis on cellulose acetate membrane were observed in 30 normal Koreans, 26 patients with cerebrovascular accident, and 18 patients with coronary heart disease. Similar measurements and observations were made in normal Koreas, surgical patients, the patients with cerebrovascular accident and hyperlipidemia in an attempt to examine the effects of body weight, surgical operations, cerebrovascular accident and the administration of clofibrate on serum lipids. The results obtained were as follows. 1. The mean values of serum cholesterol and triglyceride, which shows moderately significant correlation to the body weight in normal Koreans, were markedly higher in the patients with cerebrovascular accident and coronary heart disease than those of control. 2. Serum pre-beta- and beta-lipoprotein patterns in the densitometry of the serum lipoprotein electropherogram of the patients with coronary heart disease were larger than those of control, but the densitometric patterns of the patients with cerebrovascular accident were similar to those of control. Serum pre-beta- and beta-lipoprotein-cholesterol levels of the patients with cerebrovascular accident and coronary heart disease were higher than those of control. 3. Serum hyperlipoproteinemic type IIa and IIb were more frequently observed than type IV in the patients with cerebrovascular accident and coronary heart disease. 4. Serum cholesterol levels decreased to 74.9% of preoperation levels on the 1st postoperative day and recovered to 97.8% of preoperation levels on the 7th day. Serum triglyceride levels started to increase on the 3rd postoperative day, and reached to 115.3% of preoperation levels on the 7th day. After attack of cerebrovascular accident, serum cholesterol and triglyceride levels increased slowly to 121.7% and 133.7% of the each 1st day levels on the 7th day. 5. Serum lipid lowering effect of clofibrate was most conspicuous in the hypertriglyceridemic patients, especially during the 1st and 2nd weeks after initiation of medication, and moderately in the mixed hyperlipidemic patients. Serum pre-beta- and beta-lipoprotein-cholesterol levels were decreased after 8 weeks of clofibrate therapy, but alpha-lipoprotein-cholesterol levels did not change significantly.
Body Weight ; Cellulose ; Cholesterol* ; Clofibrate ; Coronary Disease ; Densitometry ; Electrophoresis ; Humans ; Hyperlipidemias ; Korea ; Lipoproteins* ; Membranes ; Stroke ; Triglycerides*

No abstract available.
Bronchiectasis*

No abstract available.
Cyclosporine ; Necrobiosis Lipoidica ; Necrobiotic Disorders

No abstract available.

BACKGROUND: For the evaluation of pulmonary nrtery branches after operation of right ventricular outflow obstructive disease, we reviewed the usefulness of both simple X-ray and lung perfusion scan with 99mTc-macroaggregated albumin compared with cardiac angiography. METHODS: From March, 1986 to July, 1993, at Seoul National University Children;s Hospital, we chose 23 cases who underwent both simple X-ray and cardiac angiography among the patients who had distinct difference between right and left pulmonary blood flow in lung perfusion scan after operation of right ventricular outflow obstructive disease. So we calculated the ratio of right and left pulmonary blood flow and Spearman correlation coefficient. RESULTS: Of the 23 cases, 17 cases were tetralogy of Fallot, 4 cases pulmonary atresia, 1 case double outlet right ventricle, and 1 case truncus arteriosus. The mean age at poeration was 27 months, and the mean postoperative follow-up period was for 68 months. The correlation coefficient between cardiac angiography and simple X-ray was 0.86(p<0.01), and that beteen cardiac angiography and lung perfusion scan was 0.80(p<0.01). CONCLUSION: The cardiac angiography has been known as the best diagnostic tool for the evaluation of pulmonary artery branches after operation of right ventricular outflow obstructive ddisease, but we proposed that the lung perfusion scan should be widely used because its results were similar with those of cardiac angiography.
Angiography ; Double Outlet Right Ventricle ; Follow-Up Studies ; Humans ; Lung* ; Perfusion* ; Pulmonary Artery* ; Pulmonary Atresia ; Seoul ; Tetralogy of Fallot ; Truncus Arteriosus

No abstract available.
Ductus Arteriosus, Patent*

To investigate the effect of tumor removal and administration of OK432 on the splenic natural killer (NK) cell activity in the subcutaneous tumor bearing rats, NK cell activity assay using a 4-hour 51Cr release assay and flow cytometric analysis for NK cell population were performed. The results were as follows: 1. Splenic NK cell activity and population in the subcutaneous tumor bearing rats decreased along with the growth of the tumor. 2. The rats with subcutaneous tumor removal showed decrease of splenic NK cell activity, but splenic NK cell population was not decreased. 3. In the rats with subcutaneous tumor removal and OK432 administration, splenic NK cell activity was significantly increased 1 week after administration of OK432 and then gradually returned to normal, whereas increase of NK cell population was not significant. In the present study, splenic NK cell activity was significantly decreased despite removal of subcutaneous tumor. But with the administration of OK432, splenic NK cell activity returned to normal. Considering the role of NK cells on the first line of defense against the metastatic implantation of circulating tumor emboli, we suggest that perioperative administration of immunopotentiator such as OK432 may improve the patient's outcome after surgery of human neoplasm.
Animals ; Humans ; Killer Cells, Natural* ; Picibanil* ; Rats* ; Spleen