1.Successful Treatment of an Infant with Kasabach - Merritt Syndrome with Interferon Alfa - 2a.
Jung Ho YOON ; Ki Ho KIM ; Gwang Yeol JOH
Korean Journal of Dermatology 1995;33(2):363-368
Kasabach- Merritt syndrame consists of thrombocytopenia, microangiopathic hemolytic anemia, and an acute or chronic censumptive coagulopathy in associati an with a rapidly enlarging hemangioma. Most vascular turrnrs causing Kasabach-Merritt syndon e are benign but the associated coagulopathy may be lifethreatening. Our patient, a 30-day-old female infant, was admitted after an increase in the size of a hemangioma present since birth on the right leg with extension to the lower abdomen and left inguinal area. Her herrnglobin count fell to 7.1g/dl, platelet count was 26,000/ul, prothrombin time was 26 seconds, and hypofibrinogenemia developed. The patient was treated with transfusions of platelets, fresh frozen plasma and red cells and prednisolone. for 2 weeks without improvement. We started interferon alfa-2a therapy. Over the past 6 months, he hemangioma progressively diminished in size withcut any serious complication.
Abdomen
;
Anemia, Hemolytic
;
Female
;
Hemangioma
;
Humans
;
Infant*
;
Interferon-alpha*
;
Interferons*
;
Kasabach-Merritt Syndrome
;
Leg
;
Parturition
;
Plasma
;
Platelet Count
;
Prednisolone
;
Prothrombin Time
;
Thrombocytopenia
2.A Case of Toxic Pustuloderma.
Jung Ho YOON ; Jong Taek NAM ; Ki Ho KIM ; Gwang Yeol JOH
Korean Journal of Dermatology 1994;32(5):944-949
Generalized sterile pustular eruptions occur in various dermatoses including pustular psoriasis, erythema multiforme, Sneddon-Wilkinsan disease and others. Recentlr, acute eruptions of disseminated sterile pustules have been reported. The etiology is not related to a gepetic predisposition to psoriasis but to drug ingestion or viral infections, thus termed toxic pustuloderm; (T. P.). In this report, we present a typical case of T. P. observed iu our department. Our patient, an 18-year-old male, with no personal or family history of psoriasis, was given drug medication including amoxicillin for fever and chilling sensation. Pustilar eruptions first, appeared on his face about two days aft.er the medication and gradually spread to the trunk and limbs. The skin examination revealed numerous small pustules on an erythematous base. Laboratory examination revealed neutrophilic leukocytosis and an elevated sedimentation rate skin biopsy showed subeorneal and spongiform neutrophilic pustules Upon interruption of the amoxicillin, the pustules cleared rapidly in 3 days and there has been ri.o recui rence of any rash over a 7-month follow-up period.
Adolescent
;
Amoxicillin
;
Biopsy
;
Eating
;
Erythema Multiforme
;
Exanthema
;
Extremities
;
Fever
;
Follow-Up Studies
;
Giant Cell Tumors
;
Humans
;
Leukocytosis
;
Male
;
Neutrophils
;
Psoriasis
;
Sensation
;
Skin
;
Skin Diseases
3.Lumbar HNP: Analysis of the MRI finding and comparative study between MRI and Operative finding
Sung Keun SOHN ; Kyu Yeol LEE ; Jung Yoon LEE ; Kyung Taek KIM ; Bum Ho JUNG
The Journal of the Korean Orthopaedic Association 1995;30(2):307-316
Among the 413 patients of the lumbar herniated nucleus pulposus(HNP) who were admitted and treated at Dong-A University Hospital from March 1990 to May 1994, we analyzed 387 patients who checked magnetic resonance imaging(MRI). MRI study followed by open disectomy was carried out on 127 patients of the lumbar HNP, and we analyzed the clinical and operative findings of the lumbar HNP and compared these with MRI findings. The following results were obtained. 1. MRI findings of 387 patients consisted of bulging discs in 107 cases(27.6%), protruded discs in 165 cases(42.6%), extruded subligamentous discs in 73 cases(18.9%), extruded transligamentous discs in 34 cases(8.8%) and sequestered discs in 8 cases(2.1%). 2. MRI findings of 127 patients who had been treated with open discectomy consisted of protruded discs in 53 cases(41.7%), extruded subligamentous discs in 47 cases(37.0%), extruded transligamentous discs in 19 cases(15.0%) and sequestered discs in 8 cases(6.3%). 3. Operative findings revealed the protruded discs: 49 cases(38.6%), extruded subligamentous discs: 52 cases(40.9%), extruded transligamentous discs: 18 cases(14.2%) and sequestered discs: 8 cases(6.3%). 4. In sequestered disc, we could get the highest sensitivity, specificity and accuracy with MRI in distinguishing from another type of lumbar HNP. MRI can be available for accurate assessment of type and location of the lumbar HNP and it can show the high specificity, sensitivity and accuracy in preoperative diagnostic method.
Diskectomy
;
Humans
;
Magnetic Resonance Imaging
;
Methods
;
Sensitivity and Specificity
4.Clinical study of surgical treatment of acetabular fractures.
Sung Keun SOHN ; Jung Yoon LEE ; Kyung Taek KIM ; Kyu Yeol LEE ; Yong Ho MOON
The Journal of the Korean Orthopaedic Association 1993;28(3):1120-1130
No abstract available.
Acetabulum*
5.Clinical study of the operative treatment of ankle fractures.
Jung Yoon LEE ; Sung Keun SOHN ; Kyung Taek KIM ; Kyu Yeol LEE ; Yong Ho MOON
The Journal of the Korean Orthopaedic Association 1993;28(6):2143-2152
No abstract available.
Ankle Fractures*
;
Ankle*
6.p53 Protein and Skin Sulfhydryl Oxidase Expression in Squamous Cell Carcinoma and precancerosis of Skin.
Jung Ho YOON ; Ki Ho KIM ; Gwang Yeol JOH
Korean Journal of Dermatology 1996;34(4):616-621
BACKGROUND: Extensive study of the p53 gene has established its role as a tumor-suppressor gene, and the mutant p53 gene is expressed in a wide spectrum of human malignancy. The conversion of sulfhydryl groups to disulfide bonds in epidermis is carried out by skin sulfhydryl oxidase(SSO) at the junction of the granular layer and horny layers. So it is of interest to investigate the localization and properties of SSO in epidermal keratinocytic neoplasms. OBJECTIVE: Our purpose is to investigate the expression pattern of the p53 protein and SSO and to gain a better understanding of biologic behavior in epidermal keratinocytic neoplasms. METHODS: We investigated the expression pattern of p53 protein and SSO by immunohistochemical method on formalin-fixed, paraffin-embedded tissue specimens in 8 cases of squamous cell carcinomas, several cases of recancerosis(1 Bowen's disease, 1 actinic keratosis, 1 arsenic keratosis) and benign keratinizing disorders(1 verruca vulgaris, 1 condyloma accuminatum and 2 cases of lichen planus). RESULTS: 1. Seven out of 8 cases of squamous cell carcinama(88%) and 1 case of 1 Bowen's disease showed p53 protein expression 2. SSO was weakly present in squamous cell carcinoma and precancerosis compared to the normal skin. In the well differentiated squamous cell carcinoma and Bowen's disease, the presence of SSO was rather diffuse than poorly differentiated squamous cell carcinoma and concentrated in dyskeratotic cells and horn pearls. 3. p53-stained cells or areas were seldom stained with SSO antibody, especially in invading borders of squamous cell carcinomas. CONCLUSION: Our results suggest that p53 mutation is a common genetic change in epidermal tumorigenesis and it can be useful marker of tumor invasion in the squamous cell carcinoma and precacerosis of skin.
Animals
;
Arsenic
;
Bowen's Disease
;
Carcinogenesis
;
Carcinoma, Squamous Cell*
;
Epidermis
;
Genes, p53
;
Horns
;
Humans
;
Keratosis, Actinic
;
Lichens
;
Oxidoreductases*
;
Skin*
;
Warts
7.A Case of Radiation-Induced Pemphigus.
Min Soo LEE ; Sung Moon JUNG ; Jung Ho YOON ; Gwang Yeol JOH ; Soo Chan KIM ; Ki Ho KIM
Annals of Dermatology 1998;10(3):212-215
Radiation induced pemphigus, as an example of induced pemphigus, is a rare disease which occurs in patients receiving radiotherapy. A 56-year-old male patient with nasopharyngeal cancer received 3 cycles of chemotherapy and radiotherapy on the neck and anterior chest areas. One month after completion of radio-therapy, eroded and crusted areas developed within the irradiation site. In spite of systemic antibiotic treatment, the skin lesions persisted and spread further to the trunk and upper extremities with new crops of bullae. He was treated with a high dose of prednisolone and the skin lesions cleared. We discuss the suggestive pathogenesis of radiation-induced pemphigus with the comparative results of immunoblotting in various variants of pemphigus.
Cytochrome P-450 CYP1A1
;
Drug Therapy
;
Humans
;
Immunoblotting
;
Male
;
Middle Aged
;
Nasopharyngeal Neoplasms
;
Neck
;
Pemphigus*
;
Prednisolone
;
Radiotherapy
;
Rare Diseases
;
Skin
;
Thorax
;
Upper Extremity
8.Executive Dysfunction and It's Relation to K-WAIS Scores in Mild Traumatic Brain Injury Patients with Normal Intelligence Quotient.
Dae Bo LEE ; In Seon YOON ; Seon Kyung KIM ; Seung Ho RHO ; Min Cheol PARK ; Sang Yeol LEE
Korean Journal of Psychosomatic Medicine 2012;20(1):50-58
OBJECTIVES: This study examined the selective deficits of executive function in patients with mild traumatic brain injury that in normal range of general intelligence level and aimed to analysis of the correlation between K-WAIS result and executive function. METHODS: 59 subjects were included in this study, who were diagnosed as mild traumatic brain injury(MTBI) and they have visited in neuropsychiatric department of Wonkwang University Hospital during from March, 2005 to September, 2010. For measurement of general intelligence quotient, the Korean-Wechsler Adults Intelligence Scale(K-WAIS) was administered and for measurement of executive intelligence quotient(EIQ), Executive Intelligence Test(EXIT) was administered. RESULTS: Of patients, 50.8% included at abnormal EIQ group. The patients of abnormal EIQ showed poorer full scale IQ(FIQ), performance IQ(PIQ) and in subscale that picture arrangement, digit symbol, digit span, block design, object assembly and comprehension were significantly different. In terms of relationships between K-WAIS and EIQ, FIQ and PIQ have positive correlation with EIQ. And in subscale, picture arrangement, digit symbol, digit span, block design, object assembly and comprehension show positive correlation with EIQ. CONCLUSION: This study suggest that MTBI patients with have normal range of general intelligence level may have deficit of executive function is common. The decline of FIQ, PIQ and some subscales of K-WAIS may suggest executive dysfunction in MTBI patients.
Adult
;
Brain
;
Brain Injuries
;
Comprehension
;
Executive Function
;
Humans
;
Intelligence
;
Reference Values
;
Wechsler Scales
9.Surgical Outcomes of Dysphagia Provoked by Diffuse Idiopathic Skeletal Hyperostosis in the Cervical Spine
Young Soo CHUNG ; Ho Yeol ZHANG ; Yoon HA ; Jeong Yoon PARK
Yonsei Medical Journal 2020;61(4):341-348
PURPOSE: This study aimed to predict the surgical outcomes of diffuse idiopathic skeletal hyperostosis (DISH)-related dysphagia (DISH-phagia) and to evaluate the importance of prevertebral soft tissue thickness (PVST).MATERIALS AND METHODS: In total, 21 surgeries (anterior osteophytectomy or anterior cervical decompression and fixation) were included in this study for DISH-phagia from 2003 to 2019. Clinical outcomes were assessed using the Dysphagia Outcome and Severity Scale (DOSS) preoperatively, at 1 month postoperatively, and last follow up (mean 29.5 months). PVST was measured using lateral plain radiographs. Paired t-test and Spearman's correlation test was used to identify relationships between various PVST indices and DOSS.RESULTS: Comparisons were made from 17 patients out of 21, in which the record had all of three measurements. The narrowest PVST preoperatively was 2.55±0.90 mm, with a DOSS score of 4.47±1.61, and that at 1 month after surgery was 5.02±2.33 mm, with a DOSS score of 6.12±1.32. At last follow up, PVST and DOSS values were 3.78±0.92 mm and 5.82±1.34, and three patients experienced symptom relapse. Significant relationships were found between PVST and DOSS at all time points: before surgery (R=0.702, p<0.001), 1 month after surgery (R=0.539, p=0.012), and last follow up (R=0.566, p=0.020).CONCLUSION: Surgical removal of anterior osteophytes is an effective treatment option for DISH-phagia, and PVST is a useful parameter in DISH-phagia. The goal of DISH surgery should be to remove DISH as much as possible to ensure sufficient PVST postoperatively.
10.Maternal Weight Gain Pattern and Birth Weight.
Mok Jin KIM ; Ho Yeol LEE ; Young Gi LEE ; Yoon Ki PARK ; Doo Jin LEE ; Sung Ho LEE
Yeungnam University Journal of Medicine 1998;15(1):135-142
Maternal weight gain during pregnancy has been consistently associated with infant birth weight and pregnancy outcome. Our purpose was to determined the relationship between maternal weight gain pattern and birth weight. Consequently, maternal weight gain is monitored carefully and is encouraged during prenatal care in order to improve pregnancy outcome. Our study group included both 424 uncomplicated women and infant delivered at the Yeungnam University Hospital between 1993-1996. All recorded prenatal weight gain measurements were used to estimate maternal trimester weight gain, pattern of gain (based on low versus not-low gain at each trimester), and total gain at delivery. Multiple linear regression analysis was used to assess the relationship between these weight gain measurements and fetal birth weight. Each kilogram of maternal gain in the first, second, and third trimesters was associatedwith statistically related to the increase in fatal birth weight by 31.3, 19.0, and 24.5g, respectively. When compaired with the pattern of gain that was not low in any trimester, patterns with low gain in the first trimesters were associated with significant decreases in birth weight, but no important change in birth weight was seen for the group whose gains were not low in the first trimester. The results suggest that specific patterns of maternal weight gain, particularly weight gain during the first trimester, are related to fetal birth weight.
Birth Weight*
;
Female
;
Humans
;
Infant
;
Linear Models
;
Parturition*
;
Pregnancy
;
Pregnancy Outcome
;
Pregnancy Trimester, First
;
Pregnancy Trimester, Third
;
Prenatal Care
;
Weight Gain*