1.An Immunohistochemical Study of Molluscum Contagiosum.
Ho Seok SUH ; Jee Ho CHOI ; Kyung Jeh SUNG ; Jai Kyoung KOH
Korean Journal of Dermatology 1994;32(5):787-794
BACKGROUND: Molluscum contagiosum is a common viral infect oudisease of the skin and mucous membrane that is caused by a molluscum contagiosum virus(MCV; which belongs to the poxviridae family. One of the characteristic histopathologic findings is an epidermal hyperplasia Porter and Archard reported that this phenomenon might be explained by a virus induced epidermal growth factor (EGF) like polypeptide. There was a report that epidermal prolifeation in viral infection might be modulated by other factors than the virus itself such as local immune response. OBJECTIVE: The purpose of this study was to examine the expression pattern of epidermal growth factor receptor and other immunocompetent cells by immunohistochemical stainings. METHOD : We performed iinmunoperoxidase staining on the 11 slaecmens of formalin-fixed, paraffin-embedded molluscum lesions and 15 specimens of snap frozen mollucum lesions with nine primary antibodies(EGFR, factor XIIIa, CDla, S-100 protein, MAC 387, HLA-IR, CD4, CDS, L26) RESULTS: EGF receptors were strongly expressed in lesional MCV ifect,ed keratinocytes. The number of CDla and factor XIIIa positive dermal dendritic cells were sigtly increased. In inflamed lesions, CD4 and HLA-DR expressions were increased in the dermis and per lesional epidermis. CONCLUSION: This study shows that 1) increased EGFR expression is of MCV infected keratinocytes may be related to the pathogenesis of epidermal hyperplasia. 2) helper T lyrnphocytes may operate in inflamed molluscum lesions.
Dermis
;
Epidermal Growth Factor
;
Epidermis
;
Factor XIIIa
;
HLA-DR Antigens
;
Humans
;
Hyperplasia
;
Keratinocytes
;
Langerhans Cells
;
Molluscum Contagiosum*
;
Mucous Membrane
;
Poxviridae
;
Receptor, Epidermal Growth Factor
;
S100 Proteins
;
Skin
2.Immunohistochemical study on sweat gland tumors with monoclonal antibodies against S-100 subunits.
Kyung Jeh SUNG ; Kwang Hyun CHO ; Ho Seok SUH ; Jee Ho CHOI ; Jai Kyoung KOH
Korean Journal of Dermatology 1992;30(4):446-453
S-100 protein is a mixture of three proteins, that is, S-100 ao(aa), S-100 a(ab) and, S- 100 b(bb). Twenty-two case, of sweat gland tumors were stained with immunoperoxidase technique (ABC method) for the presence of S-100a and b-subunit. Four syringomas, four eccrine poromas, two eccrine porocarcinomas, two ecerine spirdeiomas, one papillary eccrine adenoma, three clear cell hidradenomas, three mixed tumr rs of the skin, two papillary syringocystadenomas, and one cylindroma were included. All specimens were formalin-fixed and paraffin-embedded. The results were as follows : 1) The staining patterns of anti-S-100a and b-protein antibodies we e simillar to those of anti-S-100 protein antibody except in eccrine poroma and porocare nomal. 2) In eccrine poroma and porocarcinoma, scattered S-100-positive dendritic cells within tumor cell nests were stained by S-100-protein antibody (3/6), but not by anti-S-100a protein antibody. S-100p is present in normal Langerhans cells. Therefore this finding suggests that these cells niay be Langerhans cells
Acrospiroma
;
Adenoma
;
Antibodies
;
Antibodies, Monoclonal*
;
Carcinoma, Adenoid Cystic
;
Dendritic Cells
;
Eccrine Porocarcinoma
;
Immunoenzyme Techniques
;
Langerhans Cells
;
Poroma
;
S100 Proteins
;
Skin
;
Sweat Glands*
;
Sweat*
;
Syringoma
3.A Case of Acquired Digital Fibrokeratoma: Immunohistochemical Stain with Anti - factor XIIIa antibody.
Ho Seok SUH ; byung Jick RYU ; Jee Ho CHOI ; Kyung Jeh SUNG ; Jai Kyoung KOH
Korean Journal of Dermatology 1994;32(6):1131-1135
In normal hurnan dermis, factor XIIIa positive dermal dendrocyte are located in the papillary areas closely associated with blood vessels and the upper reticular dem These cells represent a specific type of bone marrow derived dermal cells, distinct from Langerhans cells having some features in common with rnonocyte/macrophage lineage and with potential antier presenting activity. Although the significance of these cells has not yet been fully established, it been suggested that they play a major role in skin immune iesponses, in collagen synsthesis regultic and in wound repair. We report a case of acaqired fibrokeratoma which is studiec conventional histopathology and immunohistochemistry. Histopathologic findings of this case showed ovascular proliferation and the increased presence of fibroblast like cells as a common fe;ture of these benign tumors. Immunohistochemical staining with anti factor XIIIa antibody deiaoi strates increased numbera of positive dendritic cells in the upper dermis. There finding supports the fat that some fibroblagt like cells in the upper dermis of acquireid fibrokeratoma may be factor XIIIa positive dermal dendritic cells.
Blood Vessels
;
Bone Marrow
;
Collagen
;
Dendritic Cells
;
Dermis
;
Factor XIIIa*
;
Fibroblasts
;
Immunohistochemistry
;
Langerhans Cells
;
Skin
;
Wounds and Injuries
4.Three Cases of Neutrophilic Eccrine Hidradenitis.
Ho Seok SUH ; Moon Soo YOON ; Jee Ho CHOI ; Kyung Jeh SUNG ; Jai Kyoung KOH
Annals of Dermatology 1995;7(2):200-205
Neutrophilic eccrine hidradenitis(NEH) was originally described in 1982 by Harrist et al. in a patient with myelogenous leukemia receiving chemotherapy. Clinically NEH represents various cutaneous manifestations with or without tenderness and pruritus. Histologic examination demonstrates a neutrophilic infiltrate within and around the eccrine gland and degeneration of the eccrine gland structures. Although the pathogenesis and possible cause of NEH remain unknown, it is probably an unusual cutaneous reaction to chemotherapeutic agents. A few cases of infection associated eccrine hidradenitis are found in the literature. We report three cases of neutrophilic eccrine hidradenitis. Two cases were associated with hematologic malignancy. The third case was associated with an infection of Vibrio vulnificus.
Drug Therapy
;
Eccrine Glands
;
Hematologic Neoplasms
;
Hidradenitis*
;
Humans
;
Leukemia, Myeloid
;
Neutrophils*
;
Pruritus
;
Vibrio vulnificus
5.Six cases of uremic pruritus treated with emollient and UVB.
Kyung Jeh SUNG ; Sung Bum KIM ; Jee Ho CHOI ; Jai Kyoung KOH
Korean Journal of Dermatology 1992;30(4):546-550
Phototherapy with UVB has become a cornerstone in treating uremic pruritus. To investigate the additional benefit of emollient, we performed emollien-phototherapy in six uremic pruritus patients on hemodialysis, one of which was not responding with UVB only. After applying mineral oil over the whole body, UVB phototh.rapy was performed two to three times weekly. Improvement was noted within one to three treatments and after three to ten treatments, pruritus markedly or totally disappeared in al six patients. This result suggests that emollient-phototherapy is as effective as, or in some patients, more effective than phototherapy with UVB only in managing uemic pruritus.
Humans
;
Mineral Oil
;
Phototherapy
;
Pruritus*
;
Renal Dialysis
6.Osteoid osteoma of the hip in children: a case report.
Dai Sung JUNG ; Young Ho JEE ; Sung Jun HONG ; Taek Jin AHN ; Jong Sool SONG
The Journal of the Korean Orthopaedic Association 1992;27(7):1940-1944
No abstract available.
Child*
;
Hip*
;
Humans
;
Osteoma, Osteoid*
7.Immunohistochemical study on granulomatous skin deseases.
Jee Ho CHOI ; Kwang Hyun CHO ; Byung Jick RYU ; Kyoung Jeh SUNG ; Jai Kyoung KOH
Korean Journal of Dermatology 1993;31(5):702-712
BACKGROUND: A definition of granuloma is a focal chronic inflammatory response to tissue injury evolved by a poorly soluble substwice characterized by the accumulation and proliferation of the mono-nuclear histiocytic cells. The accuracy with which rnononuclear cells may be identified in skir. is much improved by the use of both heteroantisera and monoclonal antibodies directed against selected cellular antigens, OBJECTIVE: Our purpose was to examine the staining patterns of anti-lysozyme, anti-a-1-antitrypsin, anti-S-100 protein antibodies, and MAC-387 monoclonal anibody in granulomatous skin diseases. METHOD: We performed imminoperoxidase staining(the labelled str prvidin-biotin peroxidase complex method on the formalin-fixed, paraffin-embedded tissue specimens of granulomatous skin diseases. RESULTS: S-100 protein positive dendritic cells were demonstrated in the granulomatous infiltrates as scattered pattern and MAC-387 positive cells were predominantly found in the center of granulomas, The staining pattern and percentage of positively stained cells of a--antitrypsin were similar to those of lysozyme. A1Pha-1-antitrypsin and lysozyme positive cells w re present in the center as well as lymphohistiocytic infiltrates of granulomas. CONCLUSION: These data sugget that histiocytes are composed of heter igeneous groups of cells such as the mononuclear-phagocyte system and dendritic cell system.
Antibodies
;
Antibodies, Monoclonal
;
Dendritic Cells
;
Granuloma
;
Histiocytes
;
Muramidase
;
Peroxidase
;
S100 Proteins
;
Skin Diseases
;
Skin*
8.A case of pulmonary lympgangioleiomyomatosis.
Sung Yi KANG ; Ki Heon YOON ; Jee Hong YOO ; Hong Mo KANG ; Moon Ho YANG
Tuberculosis and Respiratory Diseases 1992;39(3):266-270
No abstract available.
9.A Case of Meralgia Paresthetica.
Kyoung Ad JANG ; Jee Ho CHOI ; Kyung Jeh SUNG ; Kee Chan MOON ; Jai Kyoung KOH
Korean Journal of Dermatology 1998;36(5):953-955
We report a case of meralgia paresthetica in a 25-year-old man who preferred to wear tight blue jeans. He complained of a tingling sensation and dysesthesia with progressive a nature on the right thigh that had been present for 2 years. The symptoms were relieved after wearing loose trousers.
Adult
;
Humans
;
Paresthesia
;
Sensation
;
Thigh
10.Acquired Dermal Melanocytosis Occurring on the Hand.
Mi Woo LEE ; Jee Ho CHOI ; Kyung Jeh SUNG ; Kee Chan MOON ; Jai Kyoung KOH
Annals of Dermatology 2000;12(2):141-143
While most dermal melanocytoses are congenital or have an onset in early childhood, there is an acquired group with a late onset. We describe a case of aldolescent onset, unilateral, macular dermal melanocytosis on the hand. A 16-year-old girl presented with a 10-month history of gray-bluish pigmentation on the right palm and the volar side of the right fourth finger. The light microscopic studies showed spindle-shaped dermal melanocytes. The S-100 protein staining of these cells was positive and CD68 staining was negative. Dermal melanocytosis of the macular type, as observed in our case, is very rare.
Adolescent
;
Female
;
Fingers
;
Hand*
;
Humans
;
Melanocytes
;
Pigmentation
;
S100 Proteins