1.Diagnosis and Treatment of Atopic Dermatitis.
Journal of the Korean Academy of Family Medicine 2002;23(7):831-840
No absteact available.
Dermatitis, Atopic*
;
Diagnosis*
2.A case of acute febrile neutrophilic dermatosis associated with ulcerative colitis.
Ho Sun JANG ; Jang Soo LEE ; Doo Chan MOON ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1991;29(4):522-528
No abstract available.
Colitis, Ulcerative*
;
Sweet Syndrome*
;
Ulcer*
3.Clinical and Histopathological Study of Calcinosis Cutis.
Ho Sun JANG ; Moon Bum KIM ; Chang Keun OH ; Kyung Sool KWON ; Jang Soo LEE
Korean Journal of Dermatology 1999;37(2):141-149
BACKGROUND: Calcinosis cutis may occur when connective tissue is abnormal (dystrophic), or where calcium or phosphate levels in the blood are high(metastatic); alternatively, there may be no obvious underlying cause(idiopathic). The exact incidence of calcinosis cutis in dermatologic patients is not well-kniown and the pathomechanism of it remains to be elucidated. OBJECTIVE: This study was performed to analyze the incidence, clinical and histopathological features of calcinosis cutis. METHODS: We studied 72 patients with calcinosis cutis who visited our department between January 1985 and December 1996. The patients were classified into 3 types (dystrophic, metastatic, and idiopathic) and were analyzed clinically and histopathologically. Results : The results were summerized as follows; 1. There were 60 cases(83.3%) and 12 cases(16.7%) of the dystrophic and idiopathic types, respectively but the metastatic type was not observed. The frequency of dystrophic calcification in individual disorders was 88.2% in pseudoxanthoma elasticum, 66.7% in trichilemmal cyst and dermatomyositis, and 64.6% in pilomatrichoma. 2. In the idiopathic type, it was common in females aged over 50 years and the mean duration of lesions was 2.8+/-2.0 years. The predilection site was the flank(5 cases) and most of the lesions(7 cases) showed skin-colored nodules 3. Histopathologically, calcified material of the idiopathic type was located predominently in the dermis(10 cases) and was present as large masses surrounded by a foreign body reaction. 4. In the dystrophic type, calcified deposits were noted predominently within the shadow cells of pilomatricoma, in the degenerated elastic fibers of pseudoxanthoma elasticum, and in the keratinized area of basal cell carcinoma, squamous cell carcinoma, trichilemmal cyst, and epidermal cyst. Foreign body reactions with giant cells and mononuclear cell infiltrations were often found around large deposits of calcium. Conclusion : The incidence of calcinosis cutis in dermatologic patients is relatively low, but a variety of disorders can be associated with cutaneous calcification. Therefore, dermatologists should be familiar with the different forms of cutaneous calcification and the dermatoses that manifest them.
Calcinosis*
;
Calcium
;
Carcinoma, Basal Cell
;
Carcinoma, Squamous Cell
;
Connective Tissue
;
Dermatomyositis
;
Elastic Tissue
;
Epidermal Cyst
;
Female
;
Foreign Bodies
;
Foreign-Body Reaction
;
Giant Cells
;
Humans
;
Incidence
;
Pilomatrixoma
;
Pseudoxanthoma Elasticum
;
Skin Diseases
4.Malignant tumors in renal transplant recipients receiving longterm immunosuppression: Their treatment and prognosis.
Jin Ho LEE ; Yoo Sun KIM ; Chang Kwon OH ; Jang Il MOON ; Ki Il PARK
The Journal of the Korean Society for Transplantation 1993;7(1):211-215
No abstract available.
Immunosuppression*
;
Prognosis*
;
Transplantation*
5.A Case of Hypergammaglobulinemic Purpura of Waldenstrom.
Myeong Kyoo LIM ; Ho Sun JANG ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1995;33(4):789-793
Hypergammaglobulinemic purpura of Waldenstrom is characterized by recurrent episodes of petechiae, hypergammaglobulinemia, an elevated erythrocyte sedimentation rate, and the presence of rheumatoid factor, and leukocytoclastic vasculitis or mild lymphocytic perivasculitis. There is a primary type and a secondary type which is associated with other autoimmune diseases. We present a csae of a 48 year-old female with hypergammaglobulinemic purpura of Waldenstrom. She showed characteristic clinical, histopathological and laboratory findings consistent with hypergammaglobulinema purpura of Waldenstrom. Although there was a decrease in the Schimer test, we couldt den ostrate an association with Sjogrens syndrome. We think that this case may be a secondary type and needs a follow-up study.
Autoimmune Diseases
;
Blood Sedimentation
;
Female
;
Follow-Up Studies
;
Humans
;
Hypergammaglobulinemia
;
Middle Aged
;
Purpura
;
Purpura, Hyperglobulinemic*
;
Rheumatoid Factor
;
Sjogren's Syndrome
;
Vasculitis
6.A Case of Multiple Endocrine Neoplasia type 3 With Multiple Mucosal Neuroma.
Chea Wook LEE ; Chang Keun OH ; Ho Sun JANG ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1999;37(4):505-509
Multiple endocrine neoplasi~a type 3 is a rare, heritable or sporadic, multiple neoplastic disorder that is charracterized by thyroid medullary careinoma, pheochromocytoma, multiple mucosal neuroma, and marfanoid habitus. The most important disorder of the syndrome is mucosal neuroma that is an early diagnostic sign of multiple endocrine neoplasia type 3. Early diagnosis of MEN type 3 determines prognosis of the disease. We present a case of multiple endocrine neoplasia type 3 of the sporadic pattern in a 27-year-old man who had typical medullary thyroid carcinoma, mucosal neuroma, marfanoid habitus, and megacolon.
Adult
;
Early Diagnosis
;
Humans
;
Male
;
Megacolon
;
Multiple Endocrine Neoplasia*
;
Neuroma*
;
Pheochromocytoma
;
Prognosis
;
Thyroid Gland
;
Thyroid Neoplasms
7.Topographic distribution of the carcinoma in situ of the uterine cervix.
Young Ran CHUNG ; Jang Soon CHANG ; Ho Sun CHOI ; Ji Soo BYUN
Korean Journal of Obstetrics and Gynecology 1993;36(7):1178-1183
No abstract available.
Carcinoma in Situ*
;
Cervix Uteri*
;
Female
8.Apoptosis and Expression of bcl-2, p53, and Ki-67 in Mycosis Fungoides.
Jae Bong LEE ; Ho Sun JANG ; Chang Keun OH ; Kyung Sool KWON ; Jung Hum PARK
Korean Journal of Dermatology 1999;37(5):603-609
BACKGROUND: Mycosis fungoides(MF) is a form of cutaneous T cell lymphoma with clonal differentiation of helpr' T cell. It has a patch, plaque, and tumor stage. But pathogenetic factors controlling the development and progression of MF are still unclear. Apoptosis plays a major role in developmental biology and homeostasis. The bcl-2 oncogene prolongs ce11 life by inhibiting apoptosis. The mutant pS3 gene induces apoptosis indirectly. Ki-67 antigen is the cell proliferation marker. Recently, it has been shown that the relationships among them are important in the tumorigenesis of the various tumors. OBJECTIVE: The aim of this study was to examine the expression of these genes and apoptotic rate and clarify the relationship among them in the development and progression of MF. METHODS: The eighteen specimens from 8 patients with MF and 10 specimens from benign lymphocytic infiltrating diseases including 5 lichen planus, 3 lupus erythematosus, and 2 contact dermatitis were included. We performed immunoperoxidase staining(LSAB technique) using monoclonal antibodies including bc1-2, p~53, and Ki-67(MIB1). We used ApoptaqTM(Oncor) in situ labelling kit for detecting apoptotic cell.
Antibodies, Monoclonal
;
Apoptosis*
;
Carcinogenesis
;
Cell Proliferation
;
Dermatitis, Contact
;
Developmental Biology
;
Homeostasis
;
Humans
;
Ki-67 Antigen
;
Lichen Planus
;
Lymphoma, T-Cell, Cutaneous
;
Mycosis Fungoides*
;
Oncogenes
9.A Case of pseudoglucagonoma Syndrome Treated with Medium-chain Triglyceride.
Kyung Hyung SEO ; Jung Hum PARK ; Ho Sun JANG ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1997;35(3):593-599
Necrolytic migratory erythema is a rare, distinctive, necrotizing cutaneous eruption usually associated with glucagonoma, an alpha-cell tumor of the pancreas. Other clinical features include ane- mia, diabetes mellitus and weight loss. However, it also occurrs without the pancreatic glucagonoma. So this rare condition is called pseudoglucagonoma syndrome, and has been described in association with chronic hepatic diseases, malabsorption with villous atrophy, chronic pancreatitis, celiac sprue, hypoproteinemia and odontogenic infection. We report a case of pseudoglucagonoma syndrome induced by malnutrition without glucagonoma. A 28-year-old Korean female was referred to our department complaining of multiple erythematous, desquamative, crusted and erosive patches on the extremities, and diffuse scalp alopecia for 5 years. She also had perianal erosion, angular cheilitis without glossitis, amenorrhea, axillary and pubic hair loss, and weight loss. Six years previously she had had Whipples operation for a pancreatic solid and papillary neoplasm. The laboratory data showed hypoalbuminemia, essential fatty acid deficiency, diabetes mellitus and slightly high levels of zinc and glucagon. A skin biopsy showed irregular acanthosis, epidermal edema and pallor, dyskeratosis, areas of superficial epidermal necrosis and vascular dilatation of the papillary dermis. The patient improved dramatically after intravenous hyperalimentation and oral intake of mediurn chain triglyceride. For 2.5 years she has taken medium-chain triglycerides without any other treatment, and no side effects on recurrence has been observed.
Adult
;
Alopecia
;
Amenorrhea
;
Atrophy
;
Biopsy
;
Celiac Disease
;
Cheilitis
;
Dermis
;
Diabetes Mellitus
;
Dilatation
;
Edema
;
Extremities
;
Female
;
Glossitis
;
Glucagon
;
Glucagonoma
;
Hair
;
Humans
;
Hypoalbuminemia
;
Hypoproteinemia
;
Malnutrition
;
Necrolytic Migratory Erythema*
;
Necrosis
;
Pallor
;
Pancreas
;
Pancreatitis, Chronic
;
Parenteral Nutrition, Total
;
Recurrence
;
Scalp
;
Skin
;
Triglycerides*
;
Weight Loss
;
Zinc
10.Two cases of nasopharyngeal carcinoma in children.
Tae Sun HA ; Chul Ho JANG ; Hee Young SHIN ; Hyo Seop AHN
Journal of the Korean Pediatric Society 1991;34(4):587-593
No abstract available.
Child*
;
Drug Therapy
;
Humans
;
Radiotherapy