1.Angiogenensis and Overexpression of p53 Gene Produc in Brain Tumor.
Jeong Yun SHIM ; Ho Guen KIM ; Tai Seung KIM
Korean Journal of Pathology 1997;31(1):23-33
Angiogenesis depends on the net balance between positive and negative angiogenic factors. Tumor cells are angiogenic resulting from increased production of positive factors and decreased production of negative factors. Among these, vascular endothelial growth factor and glioma- derived angiogenesis inhibiting factor are related to glioblastoma multiforme. The p53 gene is more frequently mutated than any other known oncogene or tumor suppressor gene in human tumors including glioblastoma multiforme. Angiogenesis is reported to be controlled by p53 regulation in recent studies. To examine the effect of p53 overexpression on angiogenesis in glioblastoma multiforme, we performed immunohistochemical staining in 51 cases of glioblastoma multiforme, using monoclonal antibodies to p53 protein and factor VIII. 20 cases of low grade astrocytoma were used as control. p53 overexpression was present in 15(75%) of 20 cases of low grade astrocytoma and the mean vessel count was 37.7+/-9.9 at x200 field and 17.5+/-5.8 at x400 field. p53 overexpression was present in 35(68%) of 51 cases of glioblastoma multiforme and the mean vessel count was 91.9 45.8 at x200 field and 40.7 19.1 at x400 field. Mean vessel count in low grade astrocytoma with p53 overexpression was 39.4 10.2 at x200 field and 18.9 5.7 at x400 field, while in cases without p53 overexpression it was 32.4+/-7.6 at x200 field and 13.2 3.5 at x400 field. Mean vessel count in glioblastoma multiforme with p53 overexpression was 94.5+/-51.8 at x200 field and 42.1+/-16.8 at x400 field, while in cases without p53 overexpression it was 86.1+/-29.5 at x200 field and 37.1+/-16.8 at x400 field. The mean survival time was 12.4 months in the 39 cases of glioblastoma multiforme in which follow-up studies were possible. Significant prognostic factors were age, p53 overexpression and adjuvant therapy. These results show that p53 gene mutation is one of the many contributing factors to angiogenesis in glioblastoma multiforme. In addition, other oncogenes and tumor suppressor genes, as well as growth factors may be involved. Age, p53 overexpression and adjuvant therapy proved to be significant prognostic factors, while microvessel density was not.
Angiogenesis Inducing Agents
;
Antibodies, Monoclonal
;
Astrocytoma
;
Brain Neoplasms*
;
Brain*
;
Factor VIII
;
Follow-Up Studies
;
Genes, p53*
;
Genes, Tumor Suppressor
;
Glioblastoma
;
Humans
;
Intercellular Signaling Peptides and Proteins
;
Microvessels
;
Oncogenes
;
Survival Rate
;
Vascular Endothelial Growth Factor A
2.CHONDROBLSTOMA ON TEMPOROMANDIBULAR JOINT, A CASE REPORT.
Hyun Ho CHANG ; Seung Yun HAN ; Hyung Mo AHN ; Won Jong CHOI ; Jae Seung KIM
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1997;23(4):756-762
Chondroblastoma is a rare primary bone tumor which originates from cartilage, and represents approximate 1% af all bone tumor. The chondroblastoma arises most frequently from the epiphysis of the long bones with the humerus being the commonest site. It afflicts usually the young under 25 years with greater incidence in male. As there is no cartilage cell on craniofacial bone which is mainly fromed by intramembranous ossification, the chondroblastoma on the craniofacial bone is extremely rare. But the chondroblastoma recurred frequently in craniofacial bone when the mass is excised incompletely or curretted and, as the tumor has the outstanding ability of local invasiveness, it destructs the adjacent bone. In addition, it is difficult to diagnose differentially from sarcoma or giant cell tumor histopathologically. Due to the entities described above, it is necessary to remove the entire tumor mass as complete as possible, to treat with radiation pre or postoperatively for preventing from recurrence, and to observe for a long time. The chondroblastoma on temporal bone is rare and is difficult to diagnose and treat successfully. So we'd like to present a case of chondroblastoma which was originated from temporal side of TMJ with literatural review.
Cartilage
;
Chondroblastoma
;
Epiphyses
;
Giant Cell Tumors
;
Humans
;
Humerus
;
Incidence
;
Male
;
Recurrence
;
Sarcoma
;
Temporal Bone
;
Temporomandibular Joint*
3.Atherosclerosis Obliterans-induced Foot Ulcer Confused with Secondary Bacterial Infection Accompanying Tinea Pedis
Gwanghoon KIM ; Seung Ju YUN ; Ai Young LEE ; Seung Ho LEE
Korean Journal of Dermatology 2018;56(2):143-144
No abstract available.
Atherosclerosis
;
Bacterial Infections
;
Foot Ulcer
;
Foot
;
Tinea Pedis
;
Tinea
4.Eccrine Tumor Showing Combined Feature of Eccrine Hidrocystoma and Syringoma.
Seung Ju YUN ; Gwang Hoon KIM ; Jong Soo HONG ; Ai Young LEE ; Seung Ho LEE
Korean Journal of Dermatology 2018;56(7):462-463
No abstract available.
Hidrocystoma*
;
Syringoma*
5.A Case of Necrobiosis Lipoidica Treated with Cyclosporine.
Do Hun KIM ; Sang Yun JIN ; Yun Seok CHOI ; Ai Young LEE ; Seung Ho LEE
Korean Journal of Dermatology 2013;51(6):484-485
No abstract available.
Cyclosporine
;
Necrobiosis Lipoidica
;
Necrobiotic Disorders
7.Nonsurgical Percutaneous Retrieval of Catheter Emboli from the Heart.
Seung Yun CHO ; Seung Jung PARK ; Chul Ho CHO ; Nam Sik CHUNG ; Won Heum SHIM ; Woong Ku LEE
Korean Circulation Journal 1987;17(1):131-137
The increasing use of intravenous polyethylene catheters has led to a growing incidence of accidental catheter breakage and migration of fragments into the central vascular system usually in the inferior vena cave, the right atrium, of the pulmonary artery. The most common complications were formation of a thrombus in the area of the foreign body, infection with endocarditis, and perforation of the heart. And so obviously the polyethylene catheter must be removed. In 1967, Massumi and Ross et al have been successful in removing a catheter fragment from the right atrum percutaneously with a snare device. With some modification as suggested by Curry, method of retrieving fragments of polyethylene catheters from the heart without chest surgery utilize wire snares or endoscopic forceps. This report describe the technique and its use in successfully managing these complications in four consecutive cases.
Catheters*
;
Endocarditis
;
Foreign Bodies
;
Heart Atria
;
Heart*
;
Incidence
;
Polyethylene
;
Pulmonary Artery
;
SNARE Proteins
;
Surgical Instruments
;
Thorax
;
Thrombosis
8.Milia Developed on Lichen Striatus of the Face.
Sook Jung YUN ; Seong Jin KIM ; Young Ho WON ; Seung Chul LEE
Annals of Dermatology 2003;15(4):160-162
No abstract available.
Lichens*
9.Systemic Insults in the Early Death after Head Injury.
Ho Seung LEE ; Kyeong Seok LEE ; Hack Gun BAE ; Il Gyu YUN ; In Soo LEE
Journal of Korean Neurosurgical Society 1990;19(8-9):1101-1106
We present a study on the systemic insults in the early death(within one week) after head injury. The patient population consisted of 192 patients who were admitted to the Soonchunhyang University Chonan Hospital from August 1986 to May 1990 after head injury. We collected clinical features and systemic insults including blood pressure, arterial pH, PaO2, PaCO2, hematocrit, and serum concentration of Na, retrospectively. The most common cause of injury was road traffic accident(77.6%). More than half(57.8%) were under the age of 40 years. The interval from injury to admission was within one hour in 63.2%, and within four hours in 91.4%. The mean interval was 1.8 hours. However, in 154(80.2%) patients, we found the evidence of systemic insults on admission. We found hypotension(ststolic less than 90mmHg) in 22.9%, acidemia(pH<7.35) in 71.3%, arterial hypoxemia(PaO2<60mmHg) in 42.7%, hypercarbia(PaCO2>45mmHg) in 28.7%, anemia(hematocrit<30%) in 13.0%, hyponatremia(Na<135mEq/L) in 10.7%, and hypernatremia(Na>145mEq/L) in 11.2%. These results imply that the prehospital emergency care system useful at the scene of accident and during the transportation is more important than the simple quick-transport-system.
Arterial Pressure
;
Chungcheongnam-do
;
Craniocerebral Trauma*
;
Emergency Medical Services
;
Head*
;
Hematocrit
;
Humans
;
Hydrogen-Ion Concentration
;
Retrospective Studies
;
Transportation
10.A Case of Allergic Contact Dermatitis to Petrolatum.
Dohun KIM ; Sang Yun JIN ; Yunseok CHOI ; Ai Young LEE ; Seung Ho LEE
Korean Journal of Dermatology 2013;51(8):659-660
No abstract available.
Dermatitis, Allergic Contact
;
Petrolatum