Experimental, epidemiological and clinical studies indicate and important relationship between abnormalities in serum lipoproteins and atherosclerosis. With the introduction in 1965 by Fredrickson and Lees of a system for phenotyping hyperlipoproteinemias, quantitation of pre-and beta-lipoproteins gained much significance, and hence, the development of simple method for studying serum lipids and lipoproteins is needed. In the past, several methods have been proposed for the estimation of serum lipoproteins by electrophoresis. Authors observed serum total lipoprotein, beta-lipoprotein, pre-beta-lipoprotein and alpha-lipoprotein fractions in 80 (male:40, female;40)normal individuals with electrophoesis using cellulose acetate membrane instead of filter paper and concluded as follow: 1) Total lipoprotein and beta-lipoprotein levels had increasing tendency according to aging on both sexes. 2) Serum pre-beta-lipoprotein level also had increasing tendency according to age on both sexes and these features are more conspicious after fifth decade. 3) Electrophoresis using cellulose acetate membrance seem to be convinient method for analysis of serum lipoproteins especially pre-beta-lipoprotein fraction. 4) This method can be likely applied as routine screening test of hyperlipemia.
Aging ; Atherosclerosis ; Cellulose* ; Electrophoresis* ; Hyperlipidemias ; Hyperlipoproteinemias ; Lipoproteins ; Lipoproteins, LDL ; Mass Screening ; Membranes*

Although the conclusion is controversial, there has long been an appealing notion that catecholamines may be involved in some way in the pathogenesis of primary hypertension and almost invariably most of hypotensive drugs involve at various sites of the neuron and produce their effect by depletion of norepinephrine in the sympathetic nerve ending. The authors undertook the comparative study on catecholamine depleting action of 3 most effective drugs available for the treatment of hypertension, reserpine, guanethidine and alpha-methyldopa, measuring the plasma catecholamine levels and urinary exceretion of caecholamine by the modified fluorometric method of Weil-Malherbe and Bone during the treatment of hypertension. The results are as follows: 1) Before the administration of hypotensive drugs, mean blood pressure was 180/110mmH, mean psalma epinephrine level was 0.36+/-0.23gamma%, mean plasma norepinephrine level was 0.48+/-0.35gamma%, 24 hours urinary excretion of epinephrine was 3.6+/-0.12gamma/day and 24 hours urinary excretion of norepinephrine was 68.9+/-0.34gamma/day. 2) In group 1 (reserpin administered group), the mean blood pressure was 190/110mmHg before the treatment and which was declined to 155/89mmHg on the last day of 4th week, in group 2 (guanethidine administered group), the mean blood pressure measured before the treatment was 185/110mmHg and which was declined to 150/85mmHg on the last day of 4th week, and in group 3 (alpha-methylodpa administered group), the mean blood measured pressure measured before the treatment was 182/110mmHg and which was declined to 153/88mmHg on the last day of 4th week. 3) After the treatment for 4 weeks with reserpin guanethidine and alpha-methyldopa, the mean plasma epinephrine levels were declined from 0.37+/-0.12gamma% to 0.11+/-0.08gamma% in group 1, from 0.38+/-0.16gamma% to 0.14+/-0.10gamma% in group 2 and from 0.33+/-0.23gamma% to 0.10+/-0.09gamma% in group 3. 4) The mean plasma norepinephrine levels were declined from 0.05+/-0.21gamma% to 0.22+/-0.12gamma% in group 1, from 0.51+/-0.25gamma% to 0.20+/-0.10gamma% in group 2 and from 0.51+/-0.21gamma% to 0.20+/-0.11gamma% in group 3 after the treatment of 4 weeks respectively. 5) Urinary exceretion of epinephine was declined from 32.3+/-0.16gamma/day to 10.4+/-0.10gamma/day in group 1, from 34.5+/-0.34gamma/day to 17.2+/-0.16gamma/day in group 2, and from 28.2+/-0.14gamma/day to 10.3+/-0.11gamma/day in group in group 3 after the treatment of 4weeks duration. 6) The mean value of 24 hours urinary excretion of norepinephrine was declined to from 72.2+/-0.35gamma/day to 28.5+/-0.14gamma/day in group1, from 69.2+/-0.34gamma/day to 22.6+/-0.21gamma/day in group 2 and from 68.6+/-0.34gamma/day to 18.2+/-0.10gamma/day in group 3 after the treatment of 4 weeks duration. 7) From the above result we can summarized as follows: Antihypertensive effect of each drugs was; guanethidine>alpha-methylodopa>reserpin in order but depressing action plasma norepinephrine levels was; alpha-methyldopa>guanethidine>reserpin and depressing effect of urinary norepinephrine excretion was; alpha-methyldopa>guanethidine>reserpin, in order.
Antihypertensive Agents* ; Blood Pressure ; Catecholamines ; Epinephrine ; Guanethidine ; Humans ; Hypertension ; Methyldopa ; Nerve Endings ; Neurons ; Norepinephrine ; Plasma* ; Reserpine

Sixteen cases under the age of 19 were underwent surgical treatment for hernlated lumbar intervertebral disc over 10 years of period in the Department of Orthopaedic Surgery,Catholic Medical College. The results were obtained as follows: 1. The incidence was 5.2% of all herniated lumbar intervertebral disc patients who treated surgically, but no sexual predilection. 2. Nine cases (56.3%) had a definite previous history of injuries. 3. Average intervals between the onset of clinical symptoms and the operation were 9.2 months. 4. Neurologic deficits are less severe and frequent (8 cases, 50%) but the clinical symptoms do not differ from than that of the adult. 5. 7 cases (43.8%) revealed definite reptured lumbar intervertebral discs and 5 cases (31.3%) are diffuse buldging of annular fibers in operative findings. 6. According to histopathological study, 8 cases show degenerative fibrocartilagenous changes in surgical specimen. 7. The radiological abnormalities of lumbar spine are less common than that of the adult. 8. Excellent or good results were found in 12 cases (75%) but two cases required a further surgical procedure. 9. In generally, hernlated Iumbar intervertebral disc in teenagers show better results and more rapid recovery of clinical symptoms by surgical treatment, and less residual symptoms than that of the adult.
Adolescent ; Adult ; Clinical Study ; Humans ; Incidence ; Intervertebral Disc ; Neurologic Manifestations ; Spine

No abstract available.

No abstract available.
Femur* ; Phlebography* ; Prognosis*

Hypokalemic familial periodic paralysis is one of the rare familial disease characterized by recurrent and transient attacks of weakness or paralysis of the somatic musculature. Also, this disease is usually inherited as an autosomal dominant trait in most cases. During an attack, the plasma potassium falls as a rasults of shift of potassium from the extracellular to the intracelluar compartment, but there is no loss of total potassium from the body. We have experienced hypokalemic familial periodic paralysis recently which affected 4 members in a family,and report this disorder.
Accidental Falls ; Humans ; Paralyses, Familial Periodic ; Paralysis ; Plasma ; Potassium

Recently, the rates of various traffic accidents and industrial injuries accordlng to industrial progression were increased very much. In those injuries, open tibial shaft fractures were one of the most common ones of all long bones of the body. The authors have reviewed and analyzed 30 cases of the open tibial shaft fractures which were treated by pin and plaster method at our hospital from April 1976 to August 1979. The results were as follows: 1. Most of the fractures occurred in 20 and 30 age levels, average age was 34.4. Male 5 > female 1 in accident frequency. 2. The causes were traffic accident (67%), direct blow (17%), falling down from a height (13%), and mechanical trauma (3%) in order. 3. In location of fractures, Lt. 16 > Rt. 11 > both. 3; lower (47%), middle (33%), upper (20%), one thirds and comminuted (60%) > transvers (20%) > oblique (13%) > spiral (4%) > segmental fractures in frequency. 4. The associated injuries were fractures of fibulas (67%) > multiple skin damages (40%) > knee joint patella injuries... etc. Total of those injuries were 68.; One patient gained 2.26 kinds of those injuries simultaneously. 5. By classification of Ellis, minor severity (33%) > moderate one (40%) > major one fractures (27%). And according to results of pin and plaster treatment, bony union took roughly 11, 15, above 23 weeks respectively. 6. The summed contaminatlon and infection rate was below 20%, and cultured bacterias were E. Coli (50%) > staphylocci (33%) > pseudomonas (17%) and susceptabilities to penicillin were 60, 90, 25% respectively. 7. By classification of time interval from injury to apply pin and plaster method, early applied group (17 cases) showed bony union rate (7.6.4%), delayed one (11.7%), nonunion (5.8%), late group showed 50, 12.5, 6.3%, far late group showed 40, 40, 20% respectively. 8. Duration of the cast immobilization was 4–7 weeks and then it was changed by P. T. B. cast until about 4 monthes from injury, after it, vigorous P. T. was carried out. Good results were come in 80% (24 cases). 9. Pin and plaster method will be indicated in minor & moderate severity-fractures, but in major ones, it will be used as a preliminary stage operation.
Accidental Falls ; Accidents, Traffic ; Bacteria ; Classification ; Clinical Study ; Female ; Fibula ; Humans ; Immobilization ; Knee Joint ; Male ; Methods ; Patella ; Penicillins ; Pseudomonas ; Skin

Aneurysmal bone cyst is an uncommon tumor-like lesion of the bone containing distended vascular channels or cvities filled with blood. These cases, twenty-nine old female, eighteen years old male and female patients complained of pain and swelling in Rt. Medial aspect of proximal foot, Lt. proximal tibial portion and Rt. entire talar aspect of foot, respectively. Roentgenograms showed ballooned-out distensions and eccentric buldging of those lesions and soapbubble like multiple radiolucent cystic changes within interiors of the bones at talar neck, Proximal tibia and entire talus. Those cases were treated with radical curettage and autogenous iliac bone grafts and snugly fitted long leg casts in functional positions, respectively. On 2nd postoperative day, Cast windows were made and daily sterile dressings were carried out until complete wound healing. Pathological Examinations grossly and Microscopically revealed typical Aneruysmal bone cysts in all 3 cases. All-Patients had good therapeutic recovery within about seven weeks post-operatively.
Aneurysm ; Bandages ; Bone Cysts ; Bone Cysts, Aneurysmal ; Curettage ; Female ; Foot ; Humans ; Leg ; Male ; Neck ; Talus ; Tibia ; Transplants ; Wound Healing

No abstract available.
Decompression* ; Head* ; Osteonecrosis*

No abstract available.
Helicobacter pylori* ; Helicobacter* ; Urease*