A 36 year old infertile was diagnosed endometrial adenocarcinoma by endometrial biopy due to vaginal bleeding. She was characterized by obesity, hirsutism and infertility. Diagnosis was confirmed endometrial adenocarcinoma(Geade I) associated with polycystic ovarian disease postoperatively. We experienced this case and so report this case with a brief review of literatures.
Adenocarcinoma* ; Adult ; Diagnosis ; Female ; Hirsutism ; Humans ; Infertility ; Obesity ; Ovarian Diseases* ; Uterine Hemorrhage

No abstract available.

The effect of hyperbaric tetracaine spinal anesthesia was studied in 40 patients having genitourinary surgery in the horizontal lithotomy position. Patients were randomly assigned to one of two groups, after spinal injection, patients in one group were placed immediately in the supine and horizontal lithotomy position, and patients in the second group were placed immediatley in the supine and horizontal position for 10 minutes and then placed into the horizontal 1thotomy position. There were no statistically significant differences in anesthesia sensory level and heart rate of patients placed immediately in the horizontal lithotomy position compared to the patients kept in the supine position for the first 10 minutes after receiving the spinal anesthetic. The ranges of systolic blood pressure were all within normal limits, although systolic blood pressure showed a difference at 5,10 and 60 minute intervals after anesthesia. We conclude that immediate application of the horizontal lithotomy position can be safely practiced in the anesthesia of genitourinary surgery.
Anesthesia ; Anesthesia, Spinal* ; Blood Pressure ; Heart Rate ; Humans ; Injections, Spinal ; Supine Position ; Tetracaine*

It is ironic that John Gibbon's interest in the development of CPB was stimulated by his experience with a fatal case of pulmonary embolism. Massive pulmonary embolism is a siginificant cause of death in hospital, despite improvement in patient management in recent years. In Korea, none of the reports was detailed the anesthetic management of this group of physiologically compromised patients. So we describe an approach to the anesthetic management of a patients with chronic embolic occlusion of the pulmonary artery, who underwent successful pulmonary embolectomy.
Cause of Death ; Embolectomy* ; Humans ; Iron ; Korea ; Pulmonary Artery ; Pulmonary Embolism

A 30-year-old female patient presented with a progressive gait disturbance, who had been previously diagnosed for cataract and ovarian failure. Brain magnetic resonance imaging showed a high signal intensity of white matter in fluid attenuated inversion recovery and low signal intensity in brain volume imaging, suggesting demyelinating leukodystrophy. Genetic analysis confirmed the pathogenic homozygous mutations c.245T>A in the EIF2B2 gene, which is associated with vanishing white matter disease.

Curcumin is a widely used flavoring agent in food, and it has been reported to inhibit cell growth, to induce apoptosis, and to have antitumor activity in many cancers. Cisplatin is one of the most potent known anticancer agents and shows significant clinical activity against a variety of solid tumors. This study was undertaken to investigate the synergistic apoptotic effects of co-treatment with curcumin and cisplatin on human tongue SCC25 cells. To investigate whether the co-treatment efficiently reduced the viability of the SCC25 cells compared with the two treatments separately, an MTT assay was conducted. The induction and the augmentation of apoptosis were confirmed by DNA electrophoresis, Hoechst staining, and an analysis of DNA hypoploidy. Western blot, MMP and immunofluorescence tests were also performed to evaluate the expression levels and the translocation of apoptosis-related proteins following the co-treatment. In this study, following the co-treatment with curcumin and cisplatin, the SCC25 cells showed several forms of apoptotic manifestation, such as nuclear condensation, DNA fragmentation, reduction of MMP, increased levels of Bax, decreased levels of Bcl-2, and decreased DNA content. In addition, they showed a release of cytochrome c into the cytosol, translocation of AIF and DFF40 (CAD) to the nuclei, and activation of caspase-7, caspase-3, PARP, and DFF45 (ICAD). In contrast, separate treatments of 5 microM of curcumin or 4 microg/ml of cisplatin, for 24 hours, did not induce apoptosis. Therefore, our data suggest that combination therapy with curcumin and cisplatin could be considered as a novel therapeutic strategy for human oral squamous cell carcinoma.
Antineoplastic Agents ; Apoptosis ; Blotting, Western ; Carcinoma, Squamous Cell* ; Caspase 3 ; Caspase 7 ; Cell Line* ; Cisplatin* ; Curcumin* ; Cytochromes c ; Cytosol ; DNA ; DNA Fragmentation ; Electrophoresis ; Flavoring Agents ; Fluorescent Antibody Technique ; Humans ; Tongue*

Chios gum mastic (CGM) is produced from Pistiacia lentiscus L var chia, which grows only on Chios Island in Greece. CGM is a kind of resin extracted from the stem and leaves, has been used for many centuries in many Mediterranean countries as a dietary supplement and folk medicine for stomach and duodenal ulcers. CGM is known to induce cell cycle arrest and apoptosis in some cancer cells. This study was undertaken to investigate the alteration of the cell cycle and induction of apoptosis following CGM treatment of HL-60 cells. The viability of the HL-60 cells was assessed using the MTT assay. Hoechst staining and DNA electrophoresis were employed to detect HL-60 cells undergoing apoptosis. Western blotting, immunocytochemistry, confocal microscopy, FACScan flow cytometry, MMP activity and proteasome activity analyses were also employed. CGM treatment of HL-60 cells was found to result in a dose- and time-dependent decrease in cell viability and apoptotic cell death. Tested HL-60 cells showed a variety of apoptotic manifestations and induced the downregulation of G1 cell cycle-related proteins. Taken collectively, our present findings demonstrate that CGM strongly induces G1 cell cycle arrest via the modulation of cell cycle-related proteins, and also apoptosis via proteasome, mitochondrial and caspase cascades in HL-60 cells. Hence, we provide evidence that a natural product, CGM could be considered as a novel therapeutic for human leukemia.
Apoptosis ; Blotting, Western ; Cell Cycle ; Cell Cycle Checkpoints ; Cell Death ; Cell Survival ; Dietary Supplements ; DNA ; Down-Regulation ; Duodenal Ulcer ; Electrophoresis ; Flow Cytometry ; G1 Phase Cell Cycle Checkpoints ; Gingiva ; Greece ; HL-60 Cells ; Humans ; Immunohistochemistry ; Leukemia ; Medicine, Traditional ; Microscopy, Confocal ; Proteasome Endopeptidase Complex ; Proteins ; Resins, Plant ; Stomach

BACKGROUND: The possibility that anesthesia may alter the course of an infection has been under consideration for more a century. Alterations have been found in every component of the immune response during anesthesia and surgery. In this work, we have investigated the effect of lidocaine and propofol on interleukin-2 (IL-2), interleukin-4 (IL-4), and nitric oxide (NO) production in mice. METHODS: The culture supernatants of splenocytes exposed with anesthetics and lipopolysaccharide (LPS), or sera from mice injected with these agents were harvested to assay IL-2, IL-4, and NO. RESULTS: We detected that IL-2 productions of splenocytes culture supernatants and mice sera after exposure with lidocaine or propofol were decreased while IL-4 productions were increased. In addition, NO of mice sera was increased after lidocaine or propofol exposures. CONCLUSIONS: These findings suggest that lidocaine and propofol interfere with IL-2, IL-4, and NO production. This may explain the clinically well-recognized disturbance of human immunity after surgery and anesthesia.
Anesthesia ; Anesthetics ; Animals ; Humans ; Interleukin-2 ; Interleukin-4* ; Interleukins* ; Lidocaine* ; Mice* ; Nitric Oxide* ; Propofol*

PURPOSE: This study was performed to evaluate the polymerase chain reaction (PCR) in the diagnosis of Mycoplasma pneumoniae pneumonia in comparison with the specific antibody test. METHODS: Five hundred and ten patients with pneumonia, ranging from the ages of 8 months to 15 years who were admitted in Sung-Ae and Kwangmyung Sung-Ae general hospitals from Nov. 1996 to Oct. 1997, were enrolled in this study. Specific antibody test of the serum using Serodia Myco II kit and PCR of the sputum or throat swab were performed on admission simultaneously, and follow-up antibody test was done during the convalescent stage if they showed sero-negative at first. Among the PCR positive patients, 40 were treated with erythromycin initially, and were followed with PCR on the 7th day of treatment. RESULTS: The sensitivity of PCR to the specific antibody test was 82.5%, and the specificity, 98.4%. The false positive and negative rates of PCR to the specific antibody test were 1.6% and 17.5%, respectively. Fifty-six (91.8%) of the 61 patients who showed sero-negative and PCR positive on admission were determined as sero-positive at the convalescent stage. Negative conversion of PCR at the convalescent stage was noted for 32 (80%) of 40 patients who were treated with erythromycin. CONCLUSION: The PCR was considered to be valuable due to its high sensitivity and specificity as a diagnostic method of Mycoplasma pneumoniae pneumonia. The effect of the method was more apparent than the specific antibody test in early diagnosis which is clinically important. In addition, it seems to be more useful in the appreciation of treatment and epidemiologic study than the culture method that shows low sensitivity and takes too much time.
Diagnosis ; Early Diagnosis ; Epidemiologic Studies ; Erythromycin ; Follow-Up Studies ; Hospitals, General ; Humans ; Mycoplasma pneumoniae* ; Mycoplasma* ; Pharynx ; Pneumonia* ; Pneumonia, Mycoplasma* ; Polymerase Chain Reaction* ; Sensitivity and Specificity ; Sputum

PURPOSE: The development of a social system or a national economic state is accompanied by a proportional increase in the number of the aged. As the social activity of geriatric people increase, the frequency of traumatic injury also increases. In this study, to prevent geriatric trauma and to reduce medical expenses, we analyzed the factors that influence the incidence and the severity of geriatric trauma and the correlation between the factors. METHOD: The subjects of our investigation ware trauma patients over sixty-five years old who visited the Emergency Department of Yeungnam University Hospital during a period from January 1, 2003, to December 31, 2003. We retrospectively reviewed the medical charts of 436 geriatric trauma patients, and we analyzed the data by using SPSS 12.0 for Window(R). RESULT: The average age was 72.8 years, and the ratio of males to females was 1:1.1. The mean Injury Severity Score(ISS) was 10.8, and no difference was found between male and female. The mean hospitalization days were higher in patients who had a past medical history or who had a complications. Slips were the most common cause of trauma(199, 44.3%). Bicycle accidents and cultivator accidents were more common for males, but slips were more common for females. Bicycle accidents and in-car traffic accidents tended to cause longer hospitalization days. The largest number of aged trauma patients, 46, occurred during May and the smallest number, 24, during December. In addition, summer had the largest number of aged trauma patients, 93. The types of trauma, ISS, and numbers of patients did not correlate with season. The number of patients was increased on partly cloudy days, and the incidence of complication was increased in cultivator accident patients. CONCLUSION: Aged trauma patients who visit the ED for trauma must not overlook on the basis of their normal vital signs. For males, safety education is required when riding bicycles, motorcycles and cultivators. For females, encouragement to use walking aids that can prevent slips will reduce the occurrence of injury. Patients who visit by in-car TA, cultivator accidents, or bicycle accidents or who have a past medical history need to be give more care to reduce complications after hospitalization. Additionally, many side efforts must be initiated in order to reduce trauma in aged people.
Accidents, Traffic ; Education ; Emergency Service, Hospital ; Female ; Geriatrics ; Hospitalization ; Humans ; Incidence* ; Male ; Motorcycles ; Retrospective Studies ; Seasons ; Vital Signs ; Walking