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1.A Study on Plasma Antidiuretic Hormone and Serum Sodium Levels of Cord Blood in the Newborn Infants.

The present study was aimed at investigating the effect of cyclosporine A (CsA) on the renal renin-angiotensin systems. In rats chronically treated with CsA, the intrarenal expression of various genes of the renin-angiotensin system was assessed by Northern blot analysis. Along with the increases in plasma and renal renin activities, chronic CsA-treatment differentially affected the renal expression of renin-angiotensin system. The treatment with CsA for one week did not significantly alter the expression of either type 1 angiotensin II receptor (AT1A) or angiotensinogen gene, but increased the renin mRNA level. The three-week-treatment caused increases in the expression not only of renin but also of AT1A and angiotensinogen genes. Supplementation with L-arginine kept the expression of renin mRNA normal in the one-week-treated, but failed to prevent the alterations of the gene expression in the three-week-treated. Feedback control among components of the renin-angiotensin system also influences angiotesinogen. In the liver, the expression of angiotensinogen mRNA was decreased by the CsA-treatment for either one- or three-weeks. In conclusion, chronic CsA-treatment is associated with a differential expression of various genes for the renin-angiotensin system. L-Arginine may be effective in maintaining the normality of renin-angiotensin system only during early period after beginning the use of CsA.
Angiotensinogen ; Animals ; Arginine ; Blotting, Northern ; Cyclosporine* ; Gene Expression ; Liver ; Plasma ; Rats ; Receptors, Angiotensin ; Renin ; Renin-Angiotensin System* ; RNA, Messenger

1.A Study on Plasma Antidiuretic Hormone and Serum Sodium Levels of Cord Blood in the Newborn Infants.

2.Obesity in School-age Children.

3.A Clinical Study on Patients with Mycoplasma Pneumoniae Pneumonia in Childhood.

4.A Case of Myositis Ossificans Progressiva.

5.Developmental Changes of Auditory Brainstem Responses in Children.

6.Effects of Cyclosporine on the Intrarenal Renin-Angiotensin System.

7.Observation on Usefulness of RF(Rheumatoid Factor) for Screening Test.

8.MASTOPEXY AND REDUCTION MAMMOPLASTY THROUGH THE PERIAREOLAR INCISION.

9.Clinical Study of Acute Glomerulonephritis in Children.

10.Developmental Changes of Auditory Brainstem Responses in Infancy.

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