Currently, the infertile treatment and ovarian stimulation are increasingly which leads an increase of ovarian hyperstimulation syndrome. The patients with ovarian hyperstimulation syndrome can be examined and treated in any health facilities. However, most of health staffs have not thoroughly known or had experiences in the management of ovarian hyperstimulation syndrome. By knowing the risk factor, symptoms and management will help the health staff managing properly and safely the ovarian hyperstimulation syndrome
Ovarian Hyperstimulation Syndrome ; Safety

A retrospective study on 181 intrauterine insemination (IUI) cases using Aromatase (Al) in superovulation protocols treated in Tu Du hospital from August to December 2003. Daily doses of Anastrozole and Letrozole were 2mg and 2,5mg, respectively. All were used single or combined with FSH for superovulation. Results: Clinical pregnancy rates of cycles using Anastrozole, Letrozole, Anastrozole+FSH, and Letrozole+FSH were 18,8%, 22,8%, 26% and 29,3% respectively. Clinical pregnancy rates were not significantly different among cycles using Anastrozole and Letrozole. Stimulation duration were longer in cycles with Anastrozole than those with Letrozole. No adverse effect was recorded during the stimulation duration
Aromatase Inhibitors ; superovulation ; Insemination

Study on 50 cases treated by intracytoplasmic sperm injection (ICSI) at Tu Du Hospital. There were 490 sperm injected oocytes. There wasn’t difference between fertilization rates of injected ovule with normal sperm and with abnormal sperm. The embryo development rate from fertilized oocytes is better if normal sperm were injected: 25.2% of normal sperm injected oocytes developed into good quality embryos, while none of embryos generated from oocytes injected with abnormal sperm is of good quality. The selection of sperm for ICSI plays an important role in getting high results in ICSI and this procedure should be complied sperm morphologic criteria recommended by WHO in order to improve the fertilization rate and embryo quality
Sperm Injections, Intracytoplasmic ; Spermatozoa

Objective: This study aimed to investigate the impact of hyperandrogenism (HA) on the outcomes of ovulation induction (OI) using gonadotropin and intrauterine insemination (IUI) in patients with polycystic ovary syndrome (PCOS). Methods: This was a retrospective cohort study including 415 patients undergoing OI using gonadotropin and IUI treatment between January 2018 and December 2020 at a single infertility center. Baseline characteristics, clinical and laboratory parameters, and pregnancy outcomes were investigated. Results: Among the study population, there were 105 hyperandrogenic (25.3%) and 310 non-hyperandrogenic patients (74.7%). The live birth rate was lower in the HA group than in the non-HA group, but this difference did not reach statistical significance due to the limited sample size (14.3% vs. 21.0%, relative risk=0.68; 95% CI, 0.41–1.14, p=0.153). No predictive factors for live birth were identified through logistic regression analysis. Conclusion HA did not negatively affect the outcomes of OI using gonadotropin and IUI cycles in Vietnamese women with PCOS. The result may not be applicable elsewhere due to the large variation in the characteristics of women with PCOS across races and populations.

Objective: The purpose of this study was to identify factors associated with twin pregnancy following day 3 double embryo transfer (DET). Methods: This retrospective cohort study incorporated data from 16,972 day 3 DET cycles. The participants were women aged between 18 and 45 years who underwent in vitro fertilization with intracytoplasmic sperm injection (IVF/ICSI) at My Duc Assisted Reproduction Technique Unit (IVFMD), My Duc Hospital, located in Ho Chi Minh City, Vietnam. Results: Of the 16,972 day 3 DET cycles investigated, 8,812 (51.9%) resulted in pregnancy. Of these, 6,108 cycles led to clinical pregnancy, with 1,543 (25.3% of clinical pregnancies) being twin pregnancies. Factors associated with twin pregnancy included age under 35 years (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.32 to 1.71; p<0.001) and cycles involving the transfer of at least one grade I embryo. Relative to the transfer of two grade III embryos, the risk of twin pregnancy was significantly elevated following the transfer of two grade I embryos (OR, 1.40; 95% CI, 1.16 to 1.69; p<0.001) or a combination of one grade I and one grade II embryo (OR, 1.27; 95% CI, 1.05 to 1.55; p=0.001). Conclusion By analyzing a large number of IVF/ICSI cycles, we identified several predictors of twin pregnancy. These findings can assist medical professionals in tailoring treatment strategies for couples with infertility.