No abstract available.
Bone Conduction* ; Ear, Middle* ; Otitis Media* ; Otitis* ; Pathology* ; Temporal Bone*

Cystic mesothelioma of the peritoneum is a rare benign neoplasm that occurs predominantly in young to middle-aged women and tends to recur locally. Pelvic viscera is the most common predilection site of cystic mesothelioma. Authors report a case of multicystic mesothelioma of the pelvic pelvic peritoneum. The pelvic ultrasonography showed a large, confluent, and thin-walled multilocular cystic mass occupying the pelvic cavity and lower abdomen. The cystic mass was flattened and elongated. Each cyst of variable size was separated by thin septa and filled with translucent fluid. Cystic mesothelioma should be included in the differential diagnosis of the cystic peritoneal masses, especially in reproductive-aged women.
Abdomen ; Diagnosis, Differential ; Female ; Humans ; Mesothelioma* ; Mesothelioma, Cystic ; Peritoneum* ; Ultrasonography ; Viscera

We report a rescently experienced case with atypical radiologic manifestation of solid and papillary epithelial neoplasm of the pancreas in a 37 years old female patient. The tumor had heavy calcification on its capsule wall and septa. Instead of the usual encapsulated lesion with partly solid and partly cystic-hemorrhagic components, the lesion consisted of numerous fine cavitations containing air without fluid component except focal abscess fluid.
Abscess ; Female ; Humans ; Neoplasms, Glandular and Epithelial* ; Pancreas* ; Pancrelipase*

BACKGROUND: Alcohol has much effect on our lives as a taste food that people in almost all of the world generally have had. The effects of alcohol cause social problems as well as physical and psychological problems. Recently, interest about drinkirg increasingly rises as the rate of drinking accident increases in Korea. For this, our study examined the amount of alcohol consumption and early at-risk alcohol intake. METHODS: The prepared questionnaire was presented to subjects who were employees in Inchon . The anonymous, self-administered questionnaire was composed of questionnaire concerning alcohol consumption, early at-risk alcohol intake and doctor's role in drinking behaviour. RESULTS: Among 305 subjects, there were 189 (62%) men, 116 (38%) women whose mean age was 37. 9years. 87(28.5%)subjects were classified as high alcohol group and 218(71.5%) low alcohol group. High alcohol group was defined as early at-risk alcohol intake for men who were consuming 135g of alcohol per day, 630 per week and for women 90g per day, 270g per week. Low alcohol group was defined as early at-risk alcohol intake for men whose consumption was 90g per day, 450 per week and for women 45g per day, 270g per week . Mean alcohol consumption of drinker was 158.9g per week. 3 days per week people should not drink in order to avoid risk Although 54% of respondents thought doctors should ask about their drinkirg habits, only 16.4% of respondents reported ever being asked about alcohol intake on the subject. CONCLUSION: Early at-risk drinking subject in the study was much more than those suggested by NIH(National Institutes of Health). We conclude that primary care physicians should take more interest in screening, treating and preventing alcohol related problems and advise and educate patients to cut down or quit drinking.
Academies and Institutes ; Alcohol Drinking ; Anonyms and Pseudonyms ; Surveys and Questionnaires ; Drinking ; Female ; Humans ; Incheon ; Korea ; Male ; Mass Screening ; Physicians, Primary Care ; Social Problems

The authors studied the lung injury induced by endotoxemia and the effects of proteolytic agent on the lung changed by endotoxemia. Sprague-Dawley rats were intraperitoneally administrated with a single dose of endotoxin (4 mg/kg, E. coli 025 : B6 lipopolysaccharide) or with endotoxin and gabexate mesilate (200 mg/kg), a proteolytic agent, concomitantly. Rats of each group were scarificed at 9, 18, and 27 hours after injection. Light and electron microscopic examination were done. The results obtained were summarized as follows: Light microscopic exmination revealed congested capillaries and neutrophilic infiltration in both groups. Electron microscopic findings were interstitial and alveolar neutrophilic infiltration, endothelial swelling with increased pinocytotic vesicles and cytoplasmic process formation, and interstitial edema. Decrease of osmiophilic bodies in the type II pneumocytes had appeared at 9 hours after endotoxin injection. These changes were increased in severity at 18 hours and 27 hours after endotoxin injection. In the group of concomitant treatment of gabexate mesilated and endotoxin, there was no edema at 9 hours after injection. After 18 hours welling of endothelial cell and interstitial edema had appeared. However, the severity of the edema was markedly decreased. Type II pneumocytes showed well preserved osmiophilic bodies. According to these results, it is considered that administration of gabexate mesilate can significantly redeced the lung injury induced by endotoxemia.
Rats ; Animals

OBJECTIVE: This study was conducted to identify 3 to 5 years of future management issues in hospital information systems (HIS). METHODS: Two rounds of interview surveys were conducted based on the sample survey of 50 managers from 28 hospital information centers utilizing the Delphi method. RESULTS: From the survey, management issues in HIS were identified in the following order: 'top management support', 'close relationship with users', 'PACS', 'disaster recovery', improving IS strategic planning'. Compared with the 1999 survey, the issues that rank within the top 10 management issues were as follows: 'top management support', 'security and control', 'close relationship with users'. Recently surfaced issues are 'disaster recovery' and 'standardization'. The issues that dropped out of the top 10 ranks were 'network management', 'recruiting and developing IS human resource'which were very fundamental issues in the initial state of the introduction of the hospital information system. CONCLUSION: The two main significance of this study involves predicting future management issues based on the comparison of the current issues with the 1999 issues and recommendingmanagement strategies based on the classification of issues by importance and persistence.
Classification ; Hospital Information Systems* ; Humans ; Information Centers

BACKGROUND: Many trials have been conducted on the prevention of pain induced by intravenous rocuronium. The aim of this study was to assess the effectiveness of lidocaine preinjection compared with rocuronium premixed with lidocaine in minimizing pain on injection. METHODS: Seventy five patients, ASA physical status I or II, were randomly allocated to one of three groups. In the control group (n = 25), patients received saline 3 ml, followed 20 slater by rocuronium (0.6 mg/kg) only. In the lidocaine premixture group (PM, n = 25), normal saline 3 ml and rocuronium(0.6 mg/kg) premixed with lidocaine 30 mg were given intravenously, and in the lidocaine preinjection group (PI, n = 25), lidocaine 30 mg was administered before injection of rocuronium (0.6 mg/kg). Pain was assessed verbally as none, mild, moderate, and severe by the same observer. RESULTS: There was a significant reduction in the incidence and severity of pain in the PI group. Only 6 patients (24%) in the PI group experienced pain as compared to 16 patients (64%) in the PM group and 22 patients (88%) in the control group. CONCLUSIONS: Lidocaine 30 mg given before the administration of rocuronium significantly reduced the incidence and severity of rocuronium induced pain. But, lidocaine rocuronium premixtures did not significantly reduce the incidence of pain.
Humans ; Incidence ; Lidocaine*

The purpose of this study was to investigate the age-related changes of cardiovascular disease risk factors and inflammatory markers in non-obese Korean women. Subjects were 112 women over 20 years old with body mass index (BMI) less than 30 kg/m2 and were divided into 3 groups (< 40 years, 40~59 years, > or = 60 years). Mean weight and BMI in the oldest group were significantly higher than those in the other 2 younger groups (P <0.05). Mean total cholesterol, triglyceride, LDL-cholesterol and apolipoprotein B/apolipoprotein A1 ratio (BAR) in the oldest group were significantly higher than those in the youngest group (P <0.05), and mean HDL-cholesterol of the oldest group was significantly lower than that of the youngest group (P <0.05). The older-aged group showed significantly higher mean values of atherogenic index (AI) and LDL/HDL ratio (P <0.05) than the respective younger-aged group, and AI was significantly correlated with age, nitric oxide and thiobarbituric acid reactive substances (P <0.01). In addition, mean vascular cell adhesion molecule-l (VCAM-1) tended to be higher in the older-aged group than the younger group. Tumor necrosis factor-alpha, a proinflammatory maker, was significantly positively correlated with serum homocysteine, a cardiovascular disease risk factor (P <0.01). In addition, a significantly positive correlation was observed between C-reactive protein and BAR (P <0.01). Overall results suggested that the aging might affect the increase of cardiovascular disease risk factors including the serum lipid profiles, weight and BMI, and age-related increases of weight and BMI might play a role in changes in certain biomarkers of inflammation.
Aging ; Apolipoproteins ; Biomarkers ; Body Mass Index ; C-Reactive Protein ; Cardiovascular Diseases ; Cell Adhesion ; Cholesterol ; Female ; Homocysteine ; Humans ; Inflammation ; Nitric Oxide ; Risk Factors ; Thiobarbiturates ; Thiobarbituric Acid Reactive Substances ; Tumor Necrosis Factor-alpha

Inspite of technical advances, the need for pharmacologic treatment of proliferative vitreoretinopathy was increased. In order to evaluate the antiproliferative effect of various antimetabolites to the rabbit retinal pigment epithelial cell, we treated cultured rabbit retinal pigment epithelial cell with different concentration of drugs to perform dose inhibition studies. We found that the antimetabolites inhibited the proliferation of rabbit retinal pigment epithelial cell in a dose dependent and a time dependent manner. The drug concentration required for 50% inhibition of cell growth (ID50) were found to be as follows (BCNU; 6.51 mg/L, 5-FU ; 8.94 mg/L, Daunorubicin; 0.03mg/L, Mitomycin-C; 0.26mg/L).
Antimetabolites* ; Daunorubicin ; Epithelial Cells* ; Fluorouracil ; Mitomycin ; Retinaldehyde* ; Vitreoretinopathy, Proliferative

The present study was conducted to examine metabolic risk factors and total antioxidant capacity (TAC) of Korean females living in Seoul and to investigate the relationship between the metabolic risk factors and serum TAC. A total of 353 females aged between 20 and 64 participated in the study. Obesity indicators, blood pressure, serum lipid profile and fasting blood glucose were measured as metabolic risk factors. Ferric reducing antioxidant power (FRAP) assay was employed to determine serum TAC of subjects. Obesity indicators such as body mass index, waist circumference and waist-hip ratio were significantly higher in the participants aged > or = 50 y (older group) than in the participants aged 20-49 y (younger group) (p < 0.001). Blood pressure, serum total cholesterol (TC), riglyceride (TG) and fasting blood glucose were also significantly higher in the older group than in the younger group (p < 0.001), demonstrating significant positive correlations between age and MS risk factors. The association between FRAP and MS risk factors were also investigated. FRAP values showed significant positive correlations with age (p = 0.001), serum TG (p = 0.002) and TC (p = 0.03). A tendency of positive association between FRAP and waist circumference was observed without any significant difference (p = 0.06). Increased serum FRAP with central obesity and serum lipids may be interpreted as results of activation of antioxidant defense system against oxidative stress induced by metabolic syndrome (MS) constituent factors. However, to verify the function of FRAP as a potential biomarker of susceptibility to MS various contributors to the plasma antioxidant capacity and their biological relevance related to MS should be elucidated further.
Aged ; Blood Glucose ; Blood Pressure ; Body Mass Index ; Cholesterol ; Fasting ; Female ; Humans ; Obesity ; Obesity, Abdominal ; Oxidative Stress ; Plasma ; Risk Factors ; Waist Circumference ; Waist-Hip Ratio