PURPOSE: This study is to evaluate the clinical features of ischemic ophthalmoplegia including the frequency of the paralyzed cranial nerve, the difference in frequency according to the causative disease, the clinical feature of the iridoplegia in cases of the third cranial nerve involvement, and the feature and time of recovery. METHODS: We retrospectively reviewed the medical records of 26 eyes of 26 patients who had been diagnosed with ischemic ophthalmoplegia caused by diabetes mellitus (DM) or hypertension (HT). RESULTS: Twelve patients had DM, 5 patients had HT, and 9 patients had both diseases. Three patients were revealed to have DM or HT during the work-up for searching the cause of ophthalmoplegia. The third cranial nerve was most frequently paralyzed, followed by the 6th and 4th cranial nerves. The opthalmoplegia was preceded or accompanied by ocular pain or headache in 10 patients. In patients with the third cranial nerve paresis, ptosis was the first to be recovered and adduction limitation was the last to be recovered. Of the 3 patients who had iridoplegia, one patient with complete iridoplegia did not recover completely until 9 months whereas 2 patients with incomplete iridoplegia had complete recovery after one and two months, respectively. Seventy-three point seven percent of patients with ischemic ophthalmoplegia completely recovered 4.3 months after onset, and there was no difference in the recovery time among the paralyzed nerves. CONCLUSIONS: There was no difference in the frequency of the paralyzed nerve according to the causative disease, and the complete iridoplegia showed slower recovery than incomplete one. Most patients with ischemic ophthalmoplegia caused by DM or HT recovered spontaneously and did not need any further treatment.
Cranial Nerves ; Diabetes Mellitus* ; Headache ; Humans ; Hypertension* ; Medical Records ; Oculomotor Nerve ; Ophthalmoplegia* ; Paresis ; Retrospective Studies

PURPOSE: This study is to evaluate the visual prognosis and the frequency of the reoperation according to the refractive power. METHODS: We retrospectively reviewed the medical records of the 19 eyes of 19 patients with retinal detachment caused by macular hole. Patients were classified into 2 groups based on their refractive power, the high myopia group; six patients with -6 diopters or more, and the non-high myopia group; 13 patients with less than -6 diopters. The mean refractive power was -13.4 diopters in high myopia group and+0.19 diopters in non-high myopia group. All patients had vitrectomy and fluid-gas exchange at first operation and silicone oil injection was performed in cases with recurred retinal detachment after 2nd operation. RESULTS: The retina was successfully reattached in all of the 19 eyes and reoperation was needed for achieving retinal reattachment in 4 eyes (21.1%). Three eyes of high myopia group (50%) and one eye of non-high myopia group (7.3%) were reoperated and 2 eyes in high myopia group needed silicone oil injection. Non-high myopia group showed improved visual acuities as compared with preoperative visual acuity (P<0.05, paired t-test). At the last follow up, macular hole was reopened in 3 eyes (15.8%) but the retina was not detached and the 3 eyes showed worse visual acuities than the others with closed macular hole. CONCLUSIONS: Accordingly, the high myopia group had higher incidences of reoperation and worse visual outcome and only one third of the high myopia group needed silicone oil injection, even though these patients may not need silicone oil injection at the first operation.
Follow-Up Studies ; Humans ; Incidence ; Medical Records ; Myopia ; Prognosis* ; Reoperation ; Retina ; Retinal Detachment* ; Retinal Perforations* ; Retinaldehyde* ; Retrospective Studies ; Silicone Oils ; Visual Acuity ; Vitrectomy

Dermoid tumors in the medial canthal area are rare, but when present they commonly adhere to the lacrimal canaliculi. Three patients presented with a mass in the medial canthal area. The authors performed excisional biopsies, and the masses were diagnosed as dermoid tumors. In two patients, canalicular lacerations were found after mass excision, which suggested that the masses had been firmly adherent to the lacrimal canaliculi. The lacerated canaliculi were repaired after bicanalicular silicone intubation. In the remaining patient, lacrimal silicone intubation was performed at the beginning of surgery, and the mass was successfully dissected from the canaliculi, leaving them intact. Excision of dermoid tumors in the medial canthal area requires careful dissection to avoid canalicular laceration. Bicanalicular silicone intubation at the beginning of surgery is helpful for the identification of the canaliculi and for the prevention of canalicular laceration during dermoid tumor excision.
Adolescent ; Adult ; Dermoid Cyst/pathology/*surgery ; Female ; Humans ; Intubation ; Lacrimal Apparatus Diseases/pathology/*surgery ; Male ; Middle Aged ; Orbital Neoplasms/pathology/*surgery ; Postoperative Care ; Preoperative Care ; Silicones

Recintly it was reported that Insertion / Deletion polymorphism in the gene coding for Angiotensin Converting Enzyme (ACE) is asscoiated with human capacity for physical performance. This study was performed to genotyping of the ACE gene to determine the correlation between elite endurance performance and ACE I/D gene polymorphism. DNA sample was obtained from peripheral blood, hair roots and mouth epithelial cell in 739 general population and 200 elite athletic performance students. The ACE gene was amplified by polymerase chain reaction (PCR) using allele specific oligonucleotide primers. 155, 525 bp and 237 bp PCR products indicating the presence of insertion(I) and deletion(D) alleles, respectively, were clearly resolved after electrophoresis on a 2% agarose gel with ethidium bromide. Of the 200 elite athletic performance population subfects, 68(34%) showed ACE genotype 11,100(50%) genotype ID and 32(16%) genotype DD. Of the 739 general papulation subjects, 259(35.1%) showed ACE genotype 11,363(49.1%) genotype ID and 117(15.8%) genotype DD. Therefore ACE I/D gene polymorphism was not associated with human capacity for physical performance.(p>0.05)
Alleles ; Angiotensins* ; Athletic Performance ; Clinical Coding ; DNA ; DNA Primers ; Electrophoresis ; Epithelial Cells ; Ethidium ; Genotype ; Hair ; Humans ; Korea* ; Mouth ; Peptidyl-Dipeptidase A ; Polymerase Chain Reaction ; Sepharose

PURPOSE: To report the outcomes of acquired lower eyelid epiblepharon after various surgeries in thyroid associated ophthalmopathy (TAO) patients. METHODS: A retrospective review of the medical records of 53 TAO patients with acquired lower eyelid epiblepharon between October 1999 and June 2011 was performed. Data were collected on demographics, type of lower eyelid epiblepharon, the detailed surgical history such as orbital decompression, retraction repair, or epiblepharon repair and surgical outcomes including follow-up period, recurrence of epiblepharon, and post-operative complications. RESULTS: Among the 53 TAO patients with acquired lower eyelid epiblepharon, 25 eyes of 17 patients underwent surgical management; 6 eyes of orbital decompression, 1 eye of orbital decompression followed by retraction repair, 2 eyes of orbital decompression followed by epiblepharon repair, 6 eyes of lower eyelid retraction repair, and 10 eyes of epiblepharon repair. Twenty two lower eyelid epiblepharons (88%) were resolved after final surgical treatment without complication during mean 16.2 months (SD, +/-29.9 months) of follow up period; three of 6 epiblepharons that remained after orbital decompression underwent subsequent surgical management of retraction repair or epiblepharon repair, and epiblepharons were well-corrected. Mean amount of lower eyelid retraction was decreased from 1.68 mm (SD, +/-1.17 mm) to 0.29 mm (SD, +/-0.44 mm) after surgery, regardless of the type of surgery (n = 25, p < 0.000, Wilcoxon signed rank test). CONCLUSIONS: Acquired lower eyelid epiblepharon of TAO should be managed sequentially according to the general serial order of surgical managements in TAO; orbital decompression, correction of lower eyelid retraction and epiblepharon repair. Acquired lower eyelid epiblepharon was well resolved after surgical management in consecutive order, especially after repair of the lower eyelid retraction with a graft, or lower eyelid epiblepharon repair. Decreased lower eyelid retraction with a resolution of epiblepharon after surgery implied that lower eyelid retraction was associated with lower eyelid epiblepharon.
Adult ; Decompression, Surgical ; Eyelid Diseases/*surgery ; Female ; Graves Ophthalmopathy/*surgery ; Humans ; Male ; Retrospective Studies ; Statistics, Nonparametric ; Treatment Outcome

PURPOSE: Benign mixed tumor of the accessory lacrimal gland is a very rare neoplasm, with only one case with presumed origin of Wolfring's gland in domestic literature. We report our experience with a case of a nodular lesion of the lateral lower eyelid which is completely excised and histologically diagnosed as benign mixed tumor from Krause's gland. METHODS: A 68 year-old woman presented with 1 cm-sized subcutaneous mass in right lateral lower eyelid. A hard non-tender movable mass was palpated. After 6 months of observation, the mass was excised through subciliary skin incision. RESULTS: The mass was located deep to the subcutaneous tissue, inferior to lower border of tarsal plate, and was adherent to inferior forniceal conjunctiva. Round 1.2 cm-sized yellow-pink mass was completely excised. Histologic examination showed many glandular elements embedded in a myxoid ground substance, and glandular structures were composed of two layers of inner cuboidal and outer polygonal cell. It was diagnosed as benign mixed tumor from accessory lacrimal gland of Krause. CONCLUSIONS: In any case presenting lower eyelid mass lesion, benign mixed tumor of accessory lacrimal gland should be considered as one of the differential diagnosis.
Aged ; Conjunctiva* ; Diagnosis, Differential ; Eyelids ; Female ; Humans ; Lacrimal Apparatus* ; Skin ; Subcutaneous Tissue

PURPOSE: To report a case of eyeball displacement into the ethmoid sinus followed by early surgical intervention and good visual recovery. CASE SUMMARY: A 46-year-old female visited our hospital after she injured the right side of her face. Her visual acuity could not be measured and computed tomography revealed displacement of the right eyeball into the ethmoid sinus, as well as right medial orbital wall fracture and rupture of the right medial rectus muscle. She underwent surgical reduction of the herniated eyeball and surgical correction of the medial orbital wall fracture within 20 hours after the accident. Eighteen months after the surgery, visual acuity of the right eye improved from light perception to 20/28, and her color vision and visual field of the right eye improved to normal range. CONCLUSIONS: Displacement of the eyeball in the orbital wall fracture is very rare, and eyeball displacement into the ethmoid sinus is even rarer. We achieved good visual outcome through early surgical intervention. The early anatomical reduction of the displacement and wall fracture may promote improved final visual outcome in other similar cases.
Color Vision ; Ethmoid Sinus* ; Female ; Humans ; Middle Aged ; Orbit ; Reference Values ; Rupture ; Visual Acuity ; Visual Fields

PURPOSE: As orbital involvement in multiple myeloma is rare, the correct diagnosis is usually difficult. We report a case of multiple myeloma which involved the orbit, and which presented with unilateral ptosis. METHODS: A 35-year-old man was referred for the evaluation of ptosis of the left eyelid for 1 month. The levator function was normal, and there was no proptosis. Orbital computerized tomography (CT) revealed an orbital mass lesion involving the superior orbital ridge with intracranial extension. RESULTS: Excisional biopsy was performed through craniotomy and superior orbitotomy. Histopathologic examination and immunostaining result suggested a diagnosis of a plasmacytoma. The diagnosis of multiple myeloma was confirmed through bone marrow aspiration and biopsy showing diffuse infiltration of plasma cells. CONCLUSIONS: We experienced a case of multiple myeloma, which is rare in the orbit presenting unilateral ptosis. In addition, the possibility of orbital mass should be considered as an unusual cause of unilateral, acquired, progressive ptosis.
Adult ; Biopsy ; Bone Marrow ; Craniotomy ; Diagnosis ; Exophthalmos ; Eyelids ; Humans ; Multiple Myeloma* ; Orbit ; Plasma Cells ; Plasmacytoma

PURPOSE: To investigate the possibility of expanded polytetrafluoroethylene (e-PTFE) as a wrapping material for porous polyethylene orbital implant. METHODS: Two groups of 6 female New Zealand albino rabbits underwent enucleation with placement of a 12 mm porous polyethylene orbital implant wrapped in simple e-PTFE in one group (group 1) and macro-porous e-PTFE in the other group (group 2). Histopathologic sections of the implants obtained at 4, 6, 8 weeks were compared on the extent of fibrovascular ingrowth, percentage of the area of proliferated vessel, and grade of fibrosis between the two groups. RESULTS: There was no implant exposure or severe inflammation in group 1 and 2 during the observation. The extent of fibrovascular ingrowth differs only at 4 weeks. Group 1 showed less fibrovascular ingrowth (until outer 1/3) at anterior half compared with posterior one, but there was no difference between anterior and posterior half in group 2 (until middle 1/3). The percentage of the area of the proliferated vessels was higher in group 2 than group 1 at both anterior and posterior half, and the anterior/posterior ratio of the area of vessels was also higher in group 2 than group 1. The grade of fibrosis was higher in group 2 than group 1 at 4, 6, and 8 weeks. CONCLUSIONS: Macro-porous e-PTFE almost didn't disturb fibrovascular ingrowth into the orbital implant, so macro-porous e-PTFE can be used safely as a wrapping material for porous polyethylene orbital implant.
Female ; Fibrosis ; Humans ; Inflammation ; New Zealand ; Orbit* ; Orbital Implants* ; Polyethylene* ; Polytetrafluoroethylene* ; Rabbits

No abstract available.
Adult ; Behcet Syndrome/*complications/diagnosis ; Follow-Up Studies ; Humans ; Male ; Optic Disk/*pathology ; Optic Neuritis/diagnosis/*etiology ; Time Factors ; Visual Acuity