Objectives: Endoscopic variceal ligation is well established metbod of treatment for esophageal varices whereas for gastric varices there has not been any systematic report of its use as a method of treatment. To evaluated its possible clinical application, the band ligation(banding) and the method of band ligation in conjuction with submucosal ethanolamine injection(banding with sclero) were tested on canine stomach, and results were assessed.
Esophageal and Gastric Varices ; Ethanolamine ; Ligation* ; Rubber* ; Stomach

No Abstract Available.
Filtering Surgery* ; Genistein* ; Glaucoma*

Laser scanning tomography is an accurate method for the three-dimentional assessment of the optic nerve head. But its topographic measurement should be highly reproducible for early diagnosis and follow-up of patients with glaucoma. The authors evaluated the reproducibility of optic nerve head topographic measurements by the Heidelberg retina tomograph(HRT). The mean standard deviation of height measurements and the mean coefficient of variation of each parameters were calculated on the 10 independent measurements in five normal eyes. The results showed that the mean standard deviation of height measurements was 29.19 microgram. The mean coefficient of variation of the cup area, rim area, rim volume, mean cup depth and the mean retinal nerve fiber layer thickness was under 10%. Optic nerve head topographic measurement by the HRT is highly reprooucible, which may help follow-up of glaucoma patients.
Early Diagnosis ; Glaucoma ; Humans ; Nerve Fibers ; Optic Disk* ; Optic Nerve* ; Retina* ; Retinaldehyde

To access the effects of trabeculectomy or medical treatment on automated visual field progression in glaucoma, a retrospective automated visual field data were obtained for those who underwent six Humphrey C30-2 field tests over at least 4 years. The first field data was excluded. Linear regression was performed with respect to mean deviation[MD], corrected pattern standard deviation[CPSD], and mean thresholds of Glaucoma Hemifield test[GHT]. Subjects were classified as progressive or stable based on the slope and statistical significance. There were 19 persons[25eyes]in surgery group and 16 persons [27eyes]in medication group. The levels of IOP in all subjects were maintained under 21 mms of mercury during all follow-up periods. There was no difference in mean postoperative IOP between both groups[p>0.05]. There were no significant dif-ferences in numbers of aggravation respect to MD, CPSD, and GHT between two groups of surgery and medication[p>0.01]. There was no differnce in the visual field outcome between two groups of surgery and medication with same level of IOP.
Filtering Surgery ; Follow-Up Studies ; Glaucoma ; Humans ; Linear Models ; Retrospective Studies ; Trabeculectomy* ; Visual Fields*

The 362 industrial eye injuries among the 14374 out-patient who visited to Dept. of Ophthalmology, Wonju Christian Hospital, Yonsei University, College of Medicine from Jan. 1975 to Dec. 1980 were statistically evaluated. 1. Industrial eye injuries occupied 2.52% of all eye injuries. 2. The majority of industrial eye injuries was due to flying particles including dust and stones(28.04%), explosives(24.66%) which resulted in corneal foreign bodies(10.27%). 3. The final visual acuity of 82 eyes(21.98%) was 20/400 or less. And 36 eyes(9.65%) were absolutIy blinded. 4. The trade-distribution of industrial eye injuries was as follows; Stope mm(36.82%), Assistant(11.15%), Miscellaneous service (7.09%), 38.53% of industrial eye injuries of Stope men was injured by explosives.
Diptera ; Dust ; Explosive Agents ; Eye Injuries* ; Gangwon-do ; Humans ; Male ; Ophthalmology ; Outpatients ; Visual Acuity

In 1930s, Mauriac described a syndrome in diabetic children consisting of stunted growth, hepatomegaly, and delayed puberty. This syndrome was related to poorly controlled diabetes of long duration. A 14-year-old girl, who had been diagnosed as insulin dependent diabetes mellitus three years ago but had not been well controlled for diabetes, visited to hospital because of short stature, delayed puberty, and visual disturbance. On physical exam her height was 146cm(<3 percentile) and her weight was 34kg(<3 percentile) and sexual maturation was delayed as Tanner stage I. The liver was 3FB palpable below the right subcostal margin. She had hyperglycemia and elevated plasma cortisol. She was diagnosed as Mauriac syndrome. On ophthalmologic examination, the cataracts were observed on both eyes and she had also peripheral neuropathy on lower extremities. Her blood glucose was controlled strictly by regular insulin during admission, and her weight was increased and hepatomegaly was improved at discharge, two months later. We report a case of Mauriac syndrome with a brief review and related literatures.
Adolescent ; Blood Glucose ; Cataract ; Child ; Diabetes Mellitus ; Female ; Hepatomegaly ; Humans ; Hydrocortisone ; Hyperglycemia ; Insulin ; Liver ; Lower Extremity ; Peripheral Nervous System Diseases ; Plasma ; Puberty, Delayed ; Sexual Maturation

PURPOSE: At birth, as the fetus adjusts to the "new world", the fetal pulmonary circulation undergoes a striking transition, characterized by an immediate rise in pulmonary blood flow and a sustained decrease in pulmonary vascular resistance(PVR). In the factors which reduce PVR after birth, are ventilation of the lung by gas, increase of oxygen tension in pulmonary vascular system, and some vasoactive mediators. Nitric oxide(NO) is regarded as one of the vasoactive mediators. Therefore we attempted to determine endogenous NO formation in newborns by measuring urinary nitrite(NO2) and citrulline which are indexes of endogenous NO formation. METHODS: We measured the urinary excretion of NO2 and citrulline in 20 term and 15 preterm neonates at the age of 1, 3, 7 days. RESULTS: The urinary excretion of NO2 and citrulline in the neonate group was higher as compared with the older children group(P<0.05). And it increased from the 1st to the 3rd day in the neonatal period(P<0.05). Furthermore the urinary excretion of them and the gestational age were inversely related(P<0.05). CONCLUSION: These changes of the urinary excretion of NO2 and citrulline in the neonate group suggest the presence of an active physiological role of NO in the pulmonary vascular biology during neonatal transition.
Biology ; Child ; Citrulline* ; Fetus ; Gestational Age ; Humans ; Infant, Newborn* ; Lung ; Nitric Oxide* ; Oxygen ; Parturition ; Pulmonary Circulation ; Strikes, Employee ; Ventilation

Inspite of technical advances, the need for pharmacologic treatment of proliferative vitreoretinopathy was increased. In order to evaluate the antiproliferative effect of various antimetabolites to the rabbit retinal pigment epithelial cell, we treated cultured rabbit retinal pigment epithelial cell with different concentration of drugs to perform dose inhibition studies. We found that the antimetabolites inhibited the proliferation of rabbit retinal pigment epithelial cell in a dose dependent and a time dependent manner. The drug concentration required for 50% inhibition of cell growth (ID50) were found to be as follows (BCNU; 6.51 mg/L, 5-FU ; 8.94 mg/L, Daunorubicin; 0.03mg/L, Mitomycin-C; 0.26mg/L).
Antimetabolites* ; Daunorubicin ; Epithelial Cells* ; Fluorouracil ; Mitomycin ; Retinaldehyde* ; Vitreoretinopathy, Proliferative

We compared the intraocular pressure reducing effect and side effects of 0.005%Latanoprost administered once daily with 0.5%Timolol administered twice daily in patients with open-angle glaucoma or ocular hypertension. This was an open randomized study with two parallel groups and a treatment period of 12 weeks. A total of 76 patients were included:38 in the Latanoprost group and 38 in the Timolol group. Intraocular pressure was reduced from 25.92 mms of mercury to 17.12 mms of mercury[33.91%]with Latanoprost and from 22.53 mms of mercury to 18.38 mms of mercury[18.42%]with Timolol. The efficacy of Latanoprost was statistically superior to timolol[p<0.001]. Latanoprost induced a slight conjunctival hyperemia and ocular discomfort but both drugs were generally well tolerated. Iris hyperpigmentation reported as a significant side effect of Latanoprost was not observed during 12 weeks of follow-up. It is concluded that Latanoprost administered once daily in the evening reduced intraocular pressure as well as and probably more than Timolol administered twice daily.
Follow-Up Studies ; Glaucoma ; Glaucoma, Open-Angle ; Humans ; Hyperemia ; Hyperpigmentation ; Intraocular Pressure* ; Iris ; Ocular Hypertension ; Timolol*

The effect of betaxolol and dipivefrin on microcirculation of peripapil lary reina and optic disc in normal tension glaucoma was assessed. Betaxolol, selective beta-1 blocker, was known to improve the blood flow of retrobulbar arteries, and dipivefrin was known to decrease the flow of ciliary body. Total subjects were 29 normal tension glaucoma patients; 18 subjects with no previous IOP reducing eye drops during 4 weeks were assigned for betaxolol group, and 11 subjects with using timolol for dipivefrin group. The intraocular pressure was significantly reduced after instillation in betaxolol group(p<0.01), and in dipivefrin group(p<0.05). But systemic blood pressure and pulse rate were not changed after instillations in both groups. Blood flow, volume, velocity of optic disc and peripapillary retina of betaxolol group and dipivafrin group were not significantly changed. From the above results, we concluded that betaxolol and dipiverin with timolol did not influenced the microcirculation of peripapillary retina and opit disc.
Arteries ; Betaxolol* ; Blood Pressure ; Ciliary Body ; Heart Rate ; Humans ; Intraocular Pressure ; Low Tension Glaucoma* ; Microcirculation ; Ophthalmic Solutions ; Optic Disk* ; Optic Nerve* ; Retina ; Retinaldehyde* ; Timolol