The alcoholic neuropathies developed in approximately 34% of chronic alcoholics and the sexual dysfunction had been experienced in 8-54% of male alcoholics(Schiavi 1990). The aims of this study were to identify the prevalence of subclinical polyneuropathies and sexual disorders in alcohol dependence, and to evaluate the association between them. The nerve conduction velocity(NCY), electromyography(EMG), and pudendal somatosensory evoked potentials(SEPs were tested for the male alcoholics(N=34) and controls(N=17 for NCV & EMG, N=25 for pudendal SEPs). The pudendal SEPs were measured by the following procedures, in which we simulated the dorsal nerve of penis attached by the ring electrode(stimulus intensity, three times of threshold ; stimulus rate, 1-4.7Hz: stimulus duration, 0.1 or 0.2msec), and recorded at the scalp(active electrode, 2cm behind Cz ; reference electrode, Fz. The NCV and EMG detected signs of peripheral neuropathies in 79.4% of alcoholics. Among the alcoholics, 64.7% were abnormal on the pudendal SEPs. Among the alcoholics who revealed abnormality on EMG and NCV, 81.4% were abnormal on the pudendal SEPs, in which 51.9% were not responded. The P1 latencies between peripheral neuropathies and sexual disorders in the alcoholic. The prevalence of subclinical neuropathies and sexual disorders seemed to be much higher in alcohol dependence that expectation, and these two problems were relatively correlated, and our results suggested that the peripheral polyneuropathies were one of the prerequisites of sexual disorders.
Alcoholic Neuropathy ; Alcoholics ; Alcoholism* ; Electrodes ; Humans ; Male ; Neural Conduction ; Peripheral Nervous System Diseases* ; Polyneuropathies ; Prevalence ; Pudendal Nerve

BACKGROUND: Brief episodes of coronary blood flow interruption, ischemic preconditioning (IP), following a prolonged ischemia induces myocardial tolerance to ischemia and improves myocardial function during reperfusion by undefined mechanism. Recently, it has been suggested that the signal transduction pathway of the cardiomyocyte itself may involve in this protection. The aims of the present study were : (1) to examine the effect of adenosine in early phase of IP, (2) to define the relationship between the adenosine and protein kinase C(PKC) METHOD AND RESULTS: Heart isolated from New Zealand White rabbit (1.2 - 1.5kg body weight, n=78) were perfused with Tyrode solution by non-recirculating Langendorff technique. After stabilization of baseline hemodynamics, the hearts were subjected to receiving 45min global ischemia (I) and 120min reperfusion (R) with or without IP. IP was induced by a single dose of 5min I and 10min R. A part of the IP hearts, calphostin C (200nmol/L), a PKC inhibitor, was administered 5min before IP and sustained during IP regimen. Left ventricular function and coronary flow were monitored. Infarct size was determined by staining with 1% triphenyltetrazolium chloride solution and computerized planimetry. Adenosine concentration in the coronary flow was determined by HPLC. Myocardial cytosolic and membrane PKC activities were measured by (32)P-r-ATP incorporation into PKC specific peptide. Expression of PKC-e and PKC-o was determined by SDS-PAGE and Western blot. IP enhanced improvement of functional recovery (p<0.05, in the left ventricular developed and end-diastolic pressure ; p<0.01, in the coronary flow) during 120min R after 45min I. Preconditioned hearts showed reduction in the infarct size compared with the non-preconditioned hearts (p<0.05) ; however, IP-induced protection was lost by calphostin C. Adenosine release from the cardiomyocytes abruptly increased to 10-20 folds baseline just after IP manipulation and decreased rapidly on reperfusion. Cytosolic PKC activity significantly decreased in the preconidtioned hearts which received 45min I(p<0.05) and 45min I and 120min R(p<0.01), while the membrane fraction increased in the former(p<0.05) and the latter(p<0.01) groups. There was no significant difference in the PKC-o activity among all experimental groups in cytosolic and membrane fraction, however, the membrane PKC-e isoenzyme activity was increased in the preconditioned hearts which received 45min I. CONCLUSION: These results indicate that (1) a single dose of brief ischemia has an infarctlimiting effect and can improve post-ischemic contractile dysfunction after 45min subsequent sustained I ; and (2) increase of adenosine release in the earlier period of IP regimen and translocation of PKC from the cytosol to myocyte membrane may be important processes signal transduction for protection. These results suggest that cardioprotective mechanism responsible for IP in isolated rabbit heart may be initiated by adenosine and PKC.
Adenosine* ; Blotting, Western ; Body Weight ; Chromatography, High Pressure Liquid ; Cytosol ; Electrophoresis, Polyacrylamide Gel ; Heart ; Hemodynamics ; Ischemia ; Ischemic Preconditioning* ; Membranes ; Muscle Cells ; Myocytes, Cardiac ; New Zealand ; Protein Kinase C* ; Protein Kinases* ; Reperfusion ; Signal Transduction ; Ventricular Function, Left

We described a case of dyschromatosis symmetrica hereditaria in a 20-year old male patient who had spotty hyperpigmentation mingled with patches of hypopigmentation on the dorsal surfaces of both hands, feet., elbows and knees. In his family. the mother and elder brother were also affected by this disease. The histologic finding of the pigmented macule showed mild hyperkeratosis and marked increase of pigmentation at the basal cell layer, and that of the depigmented macule showed a decreased amount of melanin.
Elbow ; Foot ; Hand ; Humans ; Hyperpigmentation ; Hypopigmentation ; Knee ; Male ; Melanins ; Mothers ; Pigmentation ; Siblings ; Young Adult

No abstract available.
Carcinogens* ; Colon* ; Colonic Neoplasms* ; Humans*

Penicillinase producing Neisseria gonorrhoeae(PPNG) have been reported from various cauntries throughout the world. We have been tr ying to assess the prevalence of PPNG in Korea since May, 1980 by means of chromogenic cephalosporin method. The total number of isolated Neisseria gonorrhoeae strains in 1983 was 733, among which 679 were tested for p-lactamase production, among which 178(26. 2%) were PPNGs. In 1984, 791 strains were isolated, among which 214(27.1%) were PPNGs. In all, 392(26.7%) strains were found to be PPNGs arnong 1470 Neisseria gonorrhoeae strains tested between 1983-1984.
Korea* ; Neisseria ; Neisseria gonorrhoeae ; Penicillinase ; Prevalence* ; Seoul*

At the Venereal Disease Clinic of Choong-ku Public Health Center in Seoul ]03 male patients with uncomplicated gonococcal urethritis were allocated randomly into one of 2 treatment regimens and 101 patients were followed. All 51 patients, including PPNG infections, treated with clavulanate-potentiated amoxycillin, 375 mg, PO, t.i.d. for 5 days recovered(100%), Two(4%) of 50 patients treated with clavulanate-potentiated amoxycillin, 3. 25g, PO plus probenecid, lg, PO failed to recover. These cases were 2 of 25 Penicillinase Froducing Neisseria gonorrhoeae(PPNG) infections(failure rate of 8%) and all 25 non-PPNG infections recovered(100%). It is suggested that both of these clavulanate-potentiated amoxycillin regimens ha.ve similarly good effect with minimal side effects in the treatment of gonococcal urethritis and, because of high rate of PPNGs among circulating N, gonorrhoeae, they can be recommended as the first line treatment for gonorrhoa ir Korea.
Amoxicillin* ; Clavulanic Acid* ; Humans ; Korea ; Male* ; Neisseria ; Penicillinase ; Probenecid ; Public Health ; Seoul ; Sexually Transmitted Diseases ; Urethritis*

No abstract available.
Oncogenes* ; Rectal Neoplasms*

No abstract available.
Nipples*

We report herein two cases of cheilitis granulcmatosa which were beneficial effects with intralesional triamcinolone acetonide. Casc 1, 27-year-old, showed both lip swelling with moderate scrotal tongue for 7 years and Case 2, 50-year-old, -had lower lip swelling for 1. 4 years. Histopathologic findings show lymphohistiocytic infiltration in the dermis with focal tuberculoid granuloma in case 1 and ill-defined granuloma in case 2.
Adult ; Cheilitis* ; Dermis ; Granuloma ; Humans ; Lip ; Melkersson-Rosenthal Syndrome* ; Middle Aged ; Tongue, Fissured ; Triamcinolone Acetonide

"No-incision" bladder neck suspension, Gittes` operation, is a simple & effective technique among the various surgical technique. But occasionally patients was complained of long - term urinary retention and voiding difficulty after operation because or excessive traction of the nylon suture. We prevented them using chain cystourethrogram intraoperatively. This operation was performed under the spinal anesthesia which the patients can do the Valsalva maneuver during operation. Posterior urethrovesical angle was not significantly different between preoperative & intraoperative chain cystourethrogram. We corrected wide posterior urethrovesical angle to about 100 (mean angle of the normal range). Normal voiding after catheter removal & duration of admission was signiricantly decreased in intraoperative chain cystourethroram group(p<0.05). During 11 months follow-up, overall cure rate was 84.6% without long-term postoperatively voiding difficulty. We concluded that intraoperative chain cystourethrogram was useful methods for good results.
Anesthesia, Spinal ; Catheters ; Follow-Up Studies ; Humans ; Neck* ; Nylons ; Sutures ; Traction ; Urinary Bladder* ; Urinary Retention ; Valsalva Maneuver