Recently, in leprosy patients the frequency of the blindness due to corneal disorder has been increased. We evaluated factors influencing corneal involvement in leprosy patients for the purpose of early detection and treatment of the preventable causes of the blindness. In 100 eyes of 100 leprosy patients and 50 eyes of 50 control who had no abnormality in ocular examination. Each patient was examined with corneal sensitivity test, Schirmer test(Type I) and was graded according to severity of lagophthalmos. The results were as follows: 1. 28 eyes(28%) of the leprosy patients and 3 eyes(3%) of the control patients showed less than 5mm wetting of fiter paper respectively. 2. Corneal sensation was decreased moderately or markedly in 42 eyes(42%) of the leprosy patients and 7 eyes(14%) of the control patients respectively. 3. The values of Schirmer test and corneal sensation were decreased with increasing duration of the disease. 4. In leprosy patients, 32 patients(32%) were showed lagophthalmos. The grade of lagophthalmos was increased with increasmg duration of the disease. These results suggest that leprosy patients should be followed closely for factors(corneal sensation, decreased lacrimation, lagophthalmos) affecting cornea and that treatment directed towards this problem should be initiated early.

Yellow nail syndrome is characterized by yellow discoloration of nails, chrnnic lymphedema and respiratory dieorders such as chronic bronehitis, bronchiectasis, pleural effusion and chronic sinusitis. Other changes of nail in this syndrome are the exaggerated lateral curvature and disappearance of lunula and cuticle. These nail changes are caused by greatly slow nail growth than in normal due to the defective lymphatic drainage. We report a case of yellow nail syndrome in a 55 year-old woman who has pulmanary edema, congestive heart failure for 3 years, and yellow naiIs of all fingers and toes for 1 year.
Bronchiectasis ; Drainage ; Edema ; Female ; Fingers ; Heart Failure ; Humans ; Lymphedema ; Middle Aged ; Pleural Effusion ; Sinusitis ; Toes ; Yellow Nail Syndrome*

A Statistical analysis was made on 275 cases of urinary calculi During the period from Jan.. 1963 to Aug. 1972, on the Department of Urology of Han-il Hospital and the results were obtained as following; 1. The incidence of urinary calculi was 3.09 % of out-patients. 2. The age of the patients ranged from 20 to 30 years in approximately 70 percent. 3. A seasonal occurrence was highest during summer on 31 percent. 4. The locational distribution of urinary calculi was 71.6 percent in ureter, 18.2 percent in kidney, 7.5 percent in bladder, 2. 7 percent in urethra. 5. The locational distribution of ureter calculi was 66 percent in lower, 22 percent in middle and 12 percent in upper portion. 6. In a number of urinary calculi, 89. 8 percent was single and 5.8 percent was double and 4.4 % was more than 2. 7. The ureterolithotomy was performed on 74 of 197cases requiring surgical intervention. Cystoscopic manipulation (Spontaneous Expelled) and conservative treatment were 120 cases of 197 cases. Other manner on 3 cases. 8. The results of qualitative analysis of 240 urinary calculi showed cal. Phosphate + oxalate in 53.7 percent, Cal phosphate in 13.7 percent, Calcium phosphate + ammonate in 7.5 percent, Ca phosphate +carbonate in 7.1 percent, Ca carbonate in 5.O percent. Ca oxalate in' 4.2 percent. etc.
Calcium ; Calculi ; Carbon ; Humans ; Incidence ; Kidney ; Outpatients ; Seasons ; Statistics as Topic* ; Ureter ; Urethra ; Urinary Bladder ; Urinary Calculi ; Urolithiasis* ; Urology

No abstract available.
Hemorrhoids*

Gastric lesion in familial polyposis coli is commonly presented with fundic gland hyperplastic polyps, but duodenal and gastric adenomas together with their carcinomatous transformation have been rarely described in familial polyposis coli mostly by case reports. We present three cases of gastric adenomas in familial polyposis coli with one in synchronous development of gastric adenocarcinoma in Korea. All three cases had the family history related to familial polyosis coli and received proctocolectomy because of synchronous development of colonic adenocarcinoma. One patient developed gastric polyposis and adenocarcinoma 8 years after colectomy, and the remaining two presented with multiple polyps either in the stomach or duodenum synchronously at the time of the diagnosis of familial polyposis coli with colonic adenocarcinoma. None disclosed any evidence of Gardner's syndrome. We conclude that association of gastric adenomas in familial oplyposis coli is not uncommon and gastric adenoma-carcinoma sequence is an another important participating mechanism to understand the histogenesis of gastric carcinoma in Korea.
Adenocarcinoma ; Adenoma

No abstract available.

Generalized lipodyst,rophy is characterized by generalized loss of body fat, and is asociated vith metabolic ahnormalities, including insulin resistance, hyperglycemia., and hypertriglyceridemia. like acanthosis nigricans, generalized lipodystrophy is a cutaneous marker of insulin re.istant diabetes. We report. herein a twenty year old female witti both classic generalized lipodystripin and acanthosis nigricans, in association with insulin resistant diabetes.
Acanthosis Nigricans ; Adipose Tissue ; Female ; Humans ; Hyperglycemia ; Hypertriglyceridemia ; Insulin ; Insulin Resistance ; Lipodystrophy, Congenital Generalized*

Malignant pyoperma is a rare, chronic, progressive, destructive ulcerating skin disease of unknown cause that affects the head and neck region of young adults. The disease is progressive but responds to high doses of systemically administered steroids. We present a case of malignant pyoderma developed on the left retroauricular area in 67 year-old male. The patient died of rapidly progressive, desructive, 15cm x 20 cm sized, phagedenic ulcer on the left retroauricular and neck area despite of various extensive local and systemic treatment. Histopathologic findings of tissue from the edge of the ulcer were non-specific, showing upper dermal necrosis and mixed inflammatory cell infiltrate in the deep dermis.
Aged ; Dermis ; Head ; Humans ; Male ; Neck ; Necrosis ; Pyoderma* ; Skin Diseases ; Steroids ; Ulcer ; Young Adult

Persistent light reaction, actinic reticuloid, photosensitive eczema are three chronic photodermatoses with a feature of clinical, histological, and photobiologieal characteristics in common. These conditions were given the name of chronic persistent photosensitivity. Chronic persistent photosensitivity with the feature of photosensitive eczema developed in a 68-year-old male patient who had experienced persisited dermatitis. On phototesting the patient showed extremely severe photosensitivity to the short wave UVB. A skin biopsy showed microscopic finding of eczematous dermatitis.
Actins ; Aged ; Biopsy ; Dermatitis ; Eczema ; Humans ; Male ; Radio Waves ; Skin

Human epithelial cell line immortalized by Ad12-SV40 hybrid virus was transfected with plasmid containing HPV-16 via calcium-phosphate method. Subsequently, 8 clonal cell lines were obtained after G418 selection. Among these clonal cells, clonal cell-4(C-4) and clonal cell-6(G-6) showed increases of tumorigenic cellular properties such as saturation density, soft agar colony formation and cell aggregation. Morphological alteration such as appearane of foci was observed on these two clones after passage 6 and 7(50 to 55 days after transfection). When clonal cells and control cells were treated with MNNG(0.01ug/ml), both C-4 and C-6 showed increases of tumorigenic cellular properties and the level of increase was much more elevated as compared to clonal cells prior to MNNG treatment. Appearance of foci formation was observed in C-4 and C-6 after passage-6. After passage-8, control cells and all clonal cells showed morphological alterations. It seems that treatment of cells containing HPV-16 DNA with MNNG increases tumorigenic properties of the cells and expedite morphological transformations. (continue)
Agar ; Cell Aggregation ; Cell Line ; Clone Cells ; DNA ; Epithelial Cells* ; Human papillomavirus 16 ; Humans* ; Methylnitronitrosoguanidine ; Plasmids