2.Immunohistochemical Study of Acantholytic Cells of the Squamous Cell Carcinoma of the Skin.
Jong Min KIM ; Hye Rim PARK ; Ho Gyun LEE
Korean Journal of Dermatology 1994;32(4):669-674
BACKGROUND: Acantholysis can be seen occasionally in the cutanous squamous cell carcinoma(SCC) as a result of degenerative changes of neoplastic cells. OBJECTIVE: This study was done to investigate the keratin attern and a wide range of immunohistochemical features of acantholytic cells of cutaneous SCC. METHODS: Seventeen cases of SCC showed acantholytic cells histoloieally and formalin-fixed, paraf-finembedded biopsy specimens from them were stained by ABC(avidin-biotin-peroxidase complex) staining. Fourteen biopsy specimens from 14 cases of SCC were staincd with 3 monoclonal anti-keratin antibodies(CAM 5.2, MAK-6, and 34bE12) and 17 biopsy spec:mcns from 17 cases of SCC were stained with antibodies agairist CEA(carcinoembryonic antigen), vitamin, S-100 protein, Factor VIII-R Ag, LCA(leukocyte common antigen), and lysozyme. RESULT & CONCLUSION: Acantholytic cells of 14 cases of SCC showed consistently negative staining with CAM 5.2. The acatholytic cells showed a wide range of reactivity with MAK-6 from negative to moderately strong positivity and with 34pE12 from negative to strong positivity. A few acantholytic cells of 6 cases of SCC showed weakly positive staining with anti-CEA antibody, but acantholytic cells of all 17 cases showed consistently negative staining wit,h the other antibodies.
Acantholysis
;
Antibodies
;
Biopsy
;
Carcinoma, Squamous Cell*
;
Muramidase
;
Negative Staining
;
S100 Proteins
;
Skin*
;
Vitamins
3.Immunohistochemical Study of Acantholytic Cells of the Squamous Cell Carcinoma of the Skin.
Jong Min KIM ; Hye Rim PARK ; Ho Gyun LEE
Korean Journal of Dermatology 1994;32(4):669-674
BACKGROUND: Acantholysis can be seen occasionally in the cutanous squamous cell carcinoma(SCC) as a result of degenerative changes of neoplastic cells. OBJECTIVE: This study was done to investigate the keratin attern and a wide range of immunohistochemical features of acantholytic cells of cutaneous SCC. METHODS: Seventeen cases of SCC showed acantholytic cells histoloieally and formalin-fixed, paraf-finembedded biopsy specimens from them were stained by ABC(avidin-biotin-peroxidase complex) staining. Fourteen biopsy specimens from 14 cases of SCC were staincd with 3 monoclonal anti-keratin antibodies(CAM 5.2, MAK-6, and 34bE12) and 17 biopsy spec:mcns from 17 cases of SCC were stained with antibodies agairist CEA(carcinoembryonic antigen), vitamin, S-100 protein, Factor VIII-R Ag, LCA(leukocyte common antigen), and lysozyme. RESULT & CONCLUSION: Acantholytic cells of 14 cases of SCC showed consistently negative staining with CAM 5.2. The acatholytic cells showed a wide range of reactivity with MAK-6 from negative to moderately strong positivity and with 34pE12 from negative to strong positivity. A few acantholytic cells of 6 cases of SCC showed weakly positive staining with anti-CEA antibody, but acantholytic cells of all 17 cases showed consistently negative staining wit,h the other antibodies.
Acantholysis
;
Antibodies
;
Biopsy
;
Carcinoma, Squamous Cell*
;
Muramidase
;
Negative Staining
;
S100 Proteins
;
Skin*
;
Vitamins
4.Endoscopic Removal of Traumatic Intracerebral Hematoma via Superolateral Keyhole.
Sung Jin PARK ; Ho Gyun HA ; Ho JUNG ; Sang Keol LEE ; Moon Sun PARK
Journal of Korean Neurosurgical Society 2000;29(2):249-254
No abstract available.
Hematoma*
5.Anterior Cervical Microforaminotomy: A Minimally Invasive Anterolateral Approach for Spondylotic Lesions.
Sung Jin PARK ; Ho Gyun HA ; Ho JUNG ; Sang Keol LEE ; Moon Sun PARK
Journal of Korean Neurosurgical Society 2000;29(1):87-94
No abstract available.
6.Endoscopic Third Ventriculostomy for Adult Aqueduct Stenosis: Double Fenestration: A Case Report and Technical Note.
Yong Jin SHIM ; Ho Gyun HA ; Ho JUNG ; Yong Seog KIM ; Moon Sun PARK
Journal of Korean Neurosurgical Society 2000;29(8):1019-1023
No abstract available.
Adult*
;
Constriction, Pathologic*
;
Humans
;
Ventriculostomy*
7.Intramedullary Hemangioblastoma of Cervicomedullary Junction with Diffuse Spinal Cord Enlargement and Cyst Formation : A Case Report.
Sung Jin PARK ; Ho JUNG ; Sang Keol LEE ; Moon Sun PARK ; Ho Gyun HA ; Ki Hwa YANG
Journal of Korean Neurosurgical Society 2000;29(6):805-809
No abstract available.
Hemangioblastoma*
;
Spinal Cord*
8.A Case of Lupus Erythematosus Panniculitis with Infiltration of Atypical Lymphocytes.
Sung Ju PARK ; Kwang Soo HAN ; Ho Gyun LEE ; Jong Min KIM
Korean Journal of Dermatology 1998;36(6):1074-1077
Lupus erythematosus panniculitis is a rare variant of lupus erythematosus primarily involving a panniculus with or without discoid lupus erythematosus in the overlying skin. A 34-year-old woman showed multiple, variable-sized, indurated subcutaneous nodules on both her upper arms and axillae. A Histopathological examination revealed lobular panniculitis with infiltration of several hyperchromatic atypical large lymphocytes. The infiltrated cells were positively stained with LCA, UCHL-1, CD4, CD8, but not with CD20 and CD68. A T cell receptor -chain gene and immunoglobulin heavy chain gene rearrangement study showed no monoclonality. The result of an ANA test was positive at 1: 40 in a homogeneous pattern. Skin lesions were improved by combined therapy with daily hydroxychloroquine 400mg and prednisolone 10mg in a week and after 6weeks, resolved with atrophic depressed scars. After 4 months, she complained of symptoms of the Raynaud phenomenon and was managed by nifedipine. There has been no recurrence during follow-up for 7 months.
Adult
;
Arm
;
Axilla
;
Cicatrix
;
Female
;
Follow-Up Studies
;
Gene Rearrangement
;
Humans
;
Hydroxychloroquine
;
Immunoglobulin Heavy Chains
;
Lupus Erythematosus, Discoid
;
Lymphocytes*
;
Nifedipine
;
Panniculitis
;
Panniculitis, Lupus Erythematosus*
;
Prednisolone
;
Raynaud Disease
;
Receptors, Antigen, T-Cell
;
Recurrence
;
Skin
9.Effect of STEL-toluene on Metabolism of Benzene in Rats.
Jaehoon ROH ; Dong Chun SHIN ; Jung Gyun PARK ; Young Hahn MOON ; Ho Keun CHUNG
Korean Journal of Preventive Medicine 1988;21(1):152-162
Benzene and toluene, which are widely used aromatic hydrocarbons in workplace, are recently proved to cause health hazards due to their toxic effects. This study investigated the influence of toluene on the urinary excretion of benzene metabolite by administering short term exposure limit(STEL) of these compounds(i.e., 13.8mg/kg of benzene and 108.8mg/kg of toluene) intraperitoneally into Sprague-Dawley rats. After administration, urinary phenol concentration of rat was measured by gas chromatography for every three hours. Data were analyzed by non-parametric statistical methods using Kruskal-Wallis multi-sample test and Mann-Whitney U test. The following results were obtained: 1. Administration of STFL-benzene increased urinary phenol concentration in rats. 2. Urinary phenol concentration was increased logarithmically according to the dosage of benzene. 3. Excretion of phenol in urine was decreased when benzene and toluene were administered simultaneously compared with administering benzene alone. In Summary, these results reveal that administration of STEL of toluene has antagonistic effect of urinary excretion of benzene metabolite in rats.
Animals
;
Benzene*
;
Chromatography, Gas
;
Hydrocarbons, Aromatic
;
Metabolism*
;
Phenol
;
Rats*
;
Rats, Sprague-Dawley
;
Threshold Limit Values
;
Toluene
10.A clinical and electrophysiological studies of vincristine neurotoxicity.
Joong Won KIM ; Jong Ho WON ; Dae Sik HONG ; Hee Sook PARK ; Yang Gyun LEE
Journal of the Korean Cancer Association 1991;23(2):252-258
No abstract available.
Vincristine*