We report a case of disseminated histoplasmosis, initially diagnosed from gut nodule colonoscopically, along with evidence of lung disease. Subsequently he developed Addisonian crisis due to adrenal involvement. Lessons were learnt from the importance of detailed history-personal and social/family, as well as psychosocial aspects of illness. Public health measures to reduce bird dropping (and thus possibility of histoplasmosis) are discussed.
Histoplasmosis

No abstract available.
Histoplasmosis* ; Humans

Introduction: Histoplasmosis can present in a myriad of clinical manifestations, which often makes its diagnosis difficult and occasionally, deceptive. Case Report: We describe a case of a 33 years old gentleman who was clinically diagnosed as acute appendicitis at initial presentation in view of a one-week history of fever, right lower quadrant abdominal pain- and guarding at right iliac fossa. He had thrombocytopenia and lymphopenia on presentation. Mesenteric lymphadenitis and small bowel lesion were found intraoperatively, which was respectively biopsied and resected. Histopathological result confirms disseminated histoplasmosis. Retroviral screen was positive. He was treated with amphotericin B for one week, subsequently switched to oral itraconazole, followed by initiation of highly active antiretroviral therapy (HAART). Discussion: This case illustrates the various nature of histoplasmosis presentation. A high index of suspicion is needed to clinch the diagnosis and subsequently institute prompt treatment as disseminated disease can be fatal if left untreated in an immunosuppressed host.
Disseminated Histoplasmosis

No abstract available.
Histoplasmosis ; India

No abstract available.
Bone Marrow* ; Histoplasmosis* ; Humans

No abstract available.
Histoplasmosis* ; Lymphohistiocytosis, Hemophagocytic*

Histoplasmosis is well-characterized as a fungal disease that more commonly occurs in North America, mostly endemic in Ohio and Mississippi river valleys. The clinical spectrum of histoplasmosis ranges from asymptomatic infection to a fatal disease. Progressive disseminated histoplasmosis is typically seen in immunocompromised individuals and presents with non-specific systemic symptoms associated with cutaneous manifestations of papules and nodules.? We report a case of a 28-year old Filipino female with a history of exposure to soil activities months before consult. The patient presented with a 3-week history of erythematous macules, vesicles, and pustules over the face, arms, and trunk, which evolve into papules and plaques with hemorrhagic crusting. Patient was initially diagnosed and treated as a case of varicella but had no improvement with initial management. Histopathologic findings were consistent with histoplasmosis. The patient was started with oral itraconazole, but unexpectedly expired before any improvement in cutaneous symptoms were noted.
Disseminated histoplasmosis ; Itraconazole

No abstract available.
Histoplasmosis* ; Humans ; Immunocompetence ; Republic of Korea

Histoplasmosis is particularly virulent in infants, the elderly and immunocompromised individuals. Recently the authors experienced a case of histoplasmosis diagnosed on peripheral blood smear in a newborn. So the authors report a case with brief review of literature.
Aged ; Histoplasmosis* ; Humans ; Infant ; Infant, Newborn

Introduction: Histoplasmosis is a granulomatous infection caused by the fungus, Histoplasma capsulatum. The disseminated type can be the initial manifestation of HIV/AIDS. It may affect the lungs, skin, gastrointestinal tract, liver, spleen, genitourinary tract, heart, bone marrow, adrenal glands, lymph nodes, and the central nervous system. Cutaneous findings are diverse and most present with few nodules and ulcerative lesions with involvement of the mucosal surface. Case summary: This article describes the case of a 42-year-old male who presented fever, cough, oral ulcers, and multiple brownish nodular papules and plaques on the lips, face, trunk and extremities. Skin biopsy with tissue culture and sensitivity revealed Histoplasma capsulatum which was resistant to the recommended treatment, Amphotericin-B and Itraconazole. The patient was seropositive for HIV. Conclusion The incidence of HIV in the Philippines is rapidly increasing and we are expected to encounter more cases of opportunistic infections, such as in this case. Having a high index of clinical suspicion is important in establishing a diagnosis. In patients with HIV/AIDS or presumed to have AIDS presenting with multiple cutaneous lesions, skin biopsy for identification, culture, and sensitivity studies are valuable in determining the diagnosis and initiating treatment. Furthermore, the stigma of being diagnosed with HIV/AIDS prevents people from having HIV tests done. This causes delay in the diagnosis and treatment, and results in higher mortality. Public education and patient counseling are therefore vital in addressing the HIV epidemic.
Histoplasma ; Histoplasmosis ; HIV ; Acquired Immunodeficiency Syndrome