1.Two different types of malignant fibrous histiocytomas from pet dogs.
Sun Hee DO ; Il Hwa HONG ; Jin Kyu PARK ; Ae Ri JI ; Tae Hwan KIM ; Dong Mi KWAK ; Kyu Shik JEONG
Journal of Veterinary Science 2009;10(2):169-171
We describe 2 cases of malignant fibrous histiocytomas (MFHs) that spontaneously developed in young pet dogs. To classify these tumors, we applied a panel of antibodies (vimentin, desmin, alpha-SMA, and ED1) and Azan staining for collagen. The MFHs were most consistent with osteoclast-like giant and inflammatory cell types. The first case had positive staining for ED1 and vimentin, and given the osteoclast-like giant cells, calcification sites accompanying peripheral giant cell infiltrates. The latter case, the inflammatory cell type, exhibited a storiform-pleomorphic variant of neoplastic cells, including an ossifying matrix. MFHs are among the most highly aggressive tumors occurring in soft tissue sarcomas in elderly dogs; however, MFHs have been poorly studied from a diagnostic point of view. Herein, we describe the histologic and immunohistologic features of MFHs in detail, thus classifying the subtypes of these tumors.
Animals
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Biopsy/veterinary
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Dog Diseases/diagnosis/*pathology
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Dogs
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Female
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Histiocytoma, Malignant Fibrous/diagnosis/pathology/*veterinary
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Immunohistochemistry/veterinary
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Male
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Soft Tissue Neoplasms/diagnosis/pathology/*veterinary