Malignant fibrous histiocytoma is a rare malignant tumor of histiocytic origin, arising from either bone, or soft tissue. Six cases of malignant fibrous histiocytoma are presented with emphasis on radiographic features. Five cases are of primary bone origin and one of soft tissue. Ill-defined osteolytic bone destruction with no sclerosis and with no periosteal reaction is the principal radiologic feature of the malignant fibrous histiocytoma of bone. Therefore, malignant fibrous histiocytoma should be considered in differential diagnosis of primary intraosseous or extraosseous malignancies.
Diagnosis, Differential ; Histiocytoma, Malignant Fibrous ; Sclerosis

No abstract available.
Diagnosis, Differential ; Histiocytoma, Benign Fibrous ; Xanthogranuloma, Juvenile

Cutaneous horn is a clinical diagnosis based upon the presence of a large protuberant mass of keratin. We report a case of cutaneous horn arising from dermatofibroma in a 31-year old woman. A silver whitish colored comical hyperkeratotic protruding lesion (1.0  0.7 cm size) from the red brown colored nodule was observed. Histopathologic findings showed characteristic findings of dermatofibroma and cutaneous horn. The lesion was removed by surgical excision.
Animals ; Diagnosis ; Female ; Histiocytoma, Benign Fibrous* ; Horns* ; Humans ; Silver

Malignant fibrous histiocytoma (MFH) occurs primarily in the extremities and trunk, however primary malignant fibrous histiocytoma of the alimentary tract, particularly of the jejunum, is uncommon. This case report presents a case of malignant fibrous histiocytoma as the primary lesion of the jejunum in a 42-year-old male patient with a 10-day history of melena. A small bowel tumor was resected without complication. The final diagnosis was based on the pathological report of the surgical specimen.
Adult ; Diagnosis ; Extremities ; Histiocytoma, Malignant Fibrous* ; Humans ; Jejunum* ; Male ; Melena

BACKGROUND: Dermoscopic features may be useful in verifying the clinical diagnosis and increasing the diagnostic accuracy of dermatofibroma. There have been no systematic analyses of the dermoscopic features of dermatofibroma in Koreans or studies regarding the correlation between dermoscopic features and histologic subtypes. OBJECTIVE: To investigate the dermoscopic features of dermatofibroma in Koreans and to explore the relationship between the dermoscopic features and histologic subtypes of dermatofibroma. METHODS: The study included 83 lesions from 61 patients with dermatofibroma. Dermoscopic examination was performed via hand-held polarized dermoscopy at 10x magnification. Images were documented using a digital camera with a 3-fold optical zoom. RESULTS: The main dermoscopic structures were pigment network (63.9%), white scar-like patch (53.0%), and homogeneous area (50.6%). The frequency of homogeneous area (50.6%), scale (50.6%), ring-like structure (36.1%), exophytic papillary structure (7.2%), and telangiectasia (6.0%) was significantly higher, and globule-like structure (20.5%) and erythema (8.4%) was significantly lower in Koreans than in Caucasians (p<0.05). Eleven dermoscopic patterns including a peripheral delicate pigment network and central white scar-like patch (28.9%) and total delicate pigment network (15.7%) were observed and there was no significant difference compared to Caucasians. Seven histologic types were observed; however, the correlation between dermoscopic features and histologic subtypes was not significant. CONCLUSION: The most common pattern of dermatofibroma was pigment network and central white scar-like patch in both Koreans and Caucasians. A correlation between dermoscopic features and histologic subtypes in dermatofibroma was not found. These results may be helpful in clinically diagnosing dermatofibroma, especially in Koreans.
Dermoscopy ; Diagnosis ; Erythema ; Histiocytoma, Benign Fibrous* ; Humans ; Telangiectasis

Atrophic dermatofibroma is an uncommon variant of dermatofibroma. It lacks the classic clinical features of a dermatofibroma and is often misdiagnosed. Clinically, it is characterized by inward puckering or flat lesions which on palpation become depressed or "sink in" during biopsy. Histologically, it appears similar to dermatofibroma except that it is accompanied by dermal atrophy of more than 50% of the locoregional dermis. We report two cases of dermatofibroma with atrophic features. Dermatologists should consider a diagnosis of atrophic dermatofibroma when evaluating of atrophic, depressed lesions.
Atrophy ; Biopsy ; Dermis ; Diagnosis ; Histiocytoma, Benign Fibrous* ; Palpation

Dermatofibromas most commonly occur on limbs and rarely occur on the face. Dermatofibroma occurring on the face is associated with unusual clinicopathologic features and a more aggressive clinical course in comparison to typical cases. Additionally, the most common subtype found in previous studies was benign fibrous histiocytoma, with the keloid type being very rare (about 1% of reported cases). The aim of this study was to present our experience with a keloidal dermatofibroma of the face, which is usually missed clinically, and to discuss the treatment of a keloidal dermatofibroma in this location.
Diagnosis, Differential ; Extremities ; Forehead* ; Histiocytoma, Benign Fibrous* ; Keloid*

Malignant fibrous histiocytoma is the most common soft tissue sarcoma of late adult life, but it is rare in the pleura. We recently experienced a case of cytology of malignant fibrous histiocytoma in pleural fluid. The smear revealed histiocytic malignant cells, spindle malignant cells and inflammatory cells. The histiocytic cells showed abundant, pale cytoplasm and ovoid, irregular, eccentrically placed nuclei. The spindle cells showed elongated nuclei. Intercellular collagen was also present.
Adult ; Collagen ; Cytoplasm ; Diagnosis* ; Histiocytoma, Malignant Fibrous* ; Humans ; Pleura ; Sarcoma

PURPOSE: The purpose of this study is to assess magnetic resonance (MR) imaging findings of malignant fibrous histiocytoma (MFH) of bone and to evaluate the role of contrast-enhanced MR imaging in the diagnosis of bone MFH. MATERIALS AND METHODS: MR imagings of pathologically proven bone MFH in ten patients were reviewed. Enhanced study was also performed with Gd-DTPA. The MR images were evaluated for signal intensity, homogeneity, marginal definition, presence of internal septation, cortical destruction, soft tissue extension, joint involvement and contrast enhancement. RESULTS: Tumors showed iso- or slightly high signal intensity to muscle on T1-weighted images and heterogeneously high signal intensity on T2-weighted images. Four cases showed poor-marginated borderon T2-weighted images and four cases had internal septa. Eight of nine patients with intravenous administration of Gd-DTPA showed contrast enhancement, five were heterogeneous and three were homogeneous. All cases showed cortical destruction and soft tissue extension. Five cases showed joint involvement. CONCLUSION: Bone MFH showed similar MR imaging findings of soft tissue MFH or other malignant bone tumors, but joint involvement was suggestive finding of bone MFH.
Administration, Intravenous ; Diagnosis ; Gadolinium DTPA ; Histiocytoma ; Histiocytoma, Malignant Fibrous* ; Humans ; Joints ; Magnetic Resonance Imaging*

Fibrous histiocytoma is a tumor of a biphasic cell population of fibroblasts and histiocytes. It usually occurs in the sun-exposed skin and orbital tissue but it has also been found in the upper aerodigestive tract, salivary gland, and deep layers of scalps and face. Fibrous histiocytoma in the parotid gland is extremely rare. It must be distinguished from other spindle cell tumors of parotid gland, particularly those of epithelial and myoepithelial origins. In immunohistochemical studies, antibody markers against vimentin and smooth muscle-specific actin lead to the diagnosis of fibrous histiocytoma. The malignant fibrous histiocytoma can be differentiated by its histopathology, since it consists of pleomorphism of cells, abundant mitotic figure, atypic mitotic figure and other tissue invasion. The clinical features such as rapid growth and distant organ metastasis allow a diagnosis of malignant variants. Treatment of benign fibrous histiocytoma can be made by a wide local excision without the sacrifice of near organs.
Actins ; Diagnosis ; Fibroblasts ; Histiocytes ; Histiocytoma ; Histiocytoma, Benign Fibrous* ; Histiocytoma, Malignant Fibrous ; Neoplasm Metastasis ; Orbit ; Parotid Gland* ; Salivary Glands ; Scalp ; Skin ; Vimentin