Benign fibrous histiocytomas (BFH) represent a rare group of tumors with a common origin from the tissue histiocytes, often causing pain and space-occupying effect. BFH of bone causes diagnostic difficulties due to its atypical clinical symptoms, radiographic features and cytological characteristics, which can be easily confused with other benign lesions such as non-ossifying fibroma (NOF), giant cell tumor (GCT), and fibrous dysplasia. The lesions are prone to relapse, and the patients often show poor response to radiotherapy and chemotherapy, therefore radical lesion resection should be the therapeutic target of this disease. This paper reported a case of BFH involving the skull and reviewed the associated literatures.
Histiocytoma, Benign Fibrous ; pathology ; Humans ; Male ; Skull ; pathology ; Young Adult

A case of aneurysmal ("angiomatoid") fibrous histiocytoma (AFH) in a 12-year-old girl is presented with its unusual clinicopathologic features. The lesion had the full microscopic characteristics of AFH described in prior reports, but it also had some features that differed from the original description of the disorder, such as the involvement of subcutis, its occurrence in the scalp, and a documented history of minor trauma. The lesion clinically resembled the gross features of hemangioma. The experience in the present case raises the need for considering AFH as one of major differential diagnosis of nodular cutaneous tumors in children that simulate malignancy such as angiomatoid malignant fibrous histiocytoma and Kaposi's sarcoma.
Child ; Diagnosis, Differential ; Female ; Hemangioma/pathology ; Histiocytoma, Benign Fibrous/*pathology ; Humans ; Skin Neoplasms/diagnosis/*pathology

Sclerosing hemangiomas of the lung are benign neoplasms of uncertain histogenesis. We analysed two cases of sclerosing hemangiomas of the lung with histochemistry and electron microscopy. They had a variegated histologic appearance characterized by an admixture of solid, hemorrhagic, papillary and sclerotic lesions. Characteristic uniform round cells, unique to this tumor, were found within the stroma in all lesions. In the electron microscopic examination, we found Weibel-Palade bodies like small bodies in the tumor cells. We suspect hypothesis originating in the endothelial cell can not be completely excluded yet. Sclerosing hemangioma is a distinct clinicopathologic entity and should be distinguished from other benign neoplasms or inflammatory lesions of the lung.
Endothelium/ultrastructure ; Female ; Histiocytoma, Benign Fibrous/pathology/*ultrastructure ; Humans ; Lung Neoplasms/pathology/*ultrastructure ; Male ; Middle Aged

Adolescent ; Adult ; Female ; Histiocytoma, Benign Fibrous ; pathology ; Humans ; Male ; Nasopharyngeal Neoplasms ; pathology ; Sexual Dysfunction, Physiological

OBJECTIVETo probe into the diagnosis and treatment of malignant fibrous histiocytoma (MFH) of the prostate.

METHODSOne case of MFH of the prostate was diagnosed and treated surgically by radical remocal of the lesion, resection of the rectum and sigmoidoctomy. The clinical features, diagnosis and treatment of MFH of the prostate were reviewed and presented.

RESULTSThe patient experienced recurrence 3 weeks after operation, and then underwent radiotherapy. Two months after operation the patient died of metastasis.

CONCLUSIONMFH of the prostate has been rare clinically, with poor prognosis. Early and aggressive surgical removal of the primary lesion followed by adjuvant therapy is recommended for the treatment of the disease.

Adult ; Biopsy ; Histiocytoma, Benign Fibrous ; diagnosis ; pathology ; therapy ; Humans ; Male ; Prostatic Neoplasms ; diagnosis ; pathology ; therapy

Cell Growth Processes ; Hemangioma ; pathology ; physiopathology ; Histiocytoma, Benign Fibrous ; pathology ; physiopathology ; Humans ; Neoplasms ; physiopathology

Histiocytoma, Benign Fibrous/surgery* ; Humans ; Splenectomy ; Splenic Diseases/pathology* ; Splenic Neoplasms/surgery*

Actins ; metabolism ; Dermatofibrosarcoma ; classification ; pathology ; Desmin ; metabolism ; Head and Neck Neoplasms ; metabolism ; pathology ; Histiocytoma, Benign Fibrous ; classification ; metabolism ; pathology ; Histiocytoma, Malignant Fibrous ; classification ; metabolism ; pathology ; Humans ; Oncogene Proteins, Fusion ; metabolism ; Skin Neoplasms ; metabolism ; pathology ; Vimentin ; metabolism ; Xanthomatosis ; pathology

Diagnosis, Differential ; Histiocytoma, Benign Fibrous ; metabolism ; pathology ; Histiocytosis, Langerhans-Cell ; metabolism ; pathology ; Histiocytosis, Sinus ; metabolism ; pathology ; surgery ; Humans ; Infant ; Male ; S100 Proteins ; metabolism ; Xanthogranuloma, Juvenile ; metabolism ; pathology

Sclerosing angiomatoid nodular transformation of the spleen is a recently described benign pathologic entity that is characterized by round shaped vascular spaces that are lined by endothelial cells, and the spaces are circumscribed by granulomatoid structures. Microscopically, all the reported cases had multiple angiomatoid nodules in a fibrosclerotic stroma. Each angiomatoid nodule was made up of slit-like, round or irregular shaped vascular spaces that were lined by endothelial cells and interspersed ovoid cells. We present here the CT and dynamic gadolinium-enhanced MR findings of a patient with sclerosing angiomatoid nodular transformation. The spoke-wheel pattern that was observed on MRI in this case may be an important imaging clue for making the correct diagnosis of this benign lesion.
Adult ; Cell Transformation, Neoplastic/pathology ; Gadolinium/diagnostic use ; Histiocytoma, Benign Fibrous/*pathology/*radiography ; Humans ; *Magnetic Resonance Imaging ; Male ; Splenic Neoplasms/*pathology/*radiography ; *Tomography, X-Ray Computed