1.CT and MRI Findings of Sclerosing Angiomatoid Nodular Transformation of the Spleen: Spoke Wheel Pattern.
Devrim A KARAOSMANOGLU ; Musturay KARCAALTINCABA ; Deniz AKATA
Korean Journal of Radiology 2008;9(Suppl):S52-S55
Sclerosing angiomatoid nodular transformation of the spleen is a recently described benign pathologic entity that is characterized by round shaped vascular spaces that are lined by endothelial cells, and the spaces are circumscribed by granulomatoid structures. Microscopically, all the reported cases had multiple angiomatoid nodules in a fibrosclerotic stroma. Each angiomatoid nodule was made up of slit-like, round or irregular shaped vascular spaces that were lined by endothelial cells and interspersed ovoid cells. We present here the CT and dynamic gadolinium-enhanced MR findings of a patient with sclerosing angiomatoid nodular transformation. The spoke-wheel pattern that was observed on MRI in this case may be an important imaging clue for making the correct diagnosis of this benign lesion.
Adult
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Cell Transformation, Neoplastic/pathology
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Gadolinium/diagnostic use
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Histiocytoma, Benign Fibrous/*pathology/*radiography
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Humans
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*Magnetic Resonance Imaging
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Male
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Splenic Neoplasms/*pathology/*radiography
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*Tomography, X-Ray Computed
2.Solitary nodule in lower lobe of right lobe.
Qin CHEN ; Yan-biao FU ; Bai-zhou LI
Chinese Journal of Pathology 2011;40(2):117-119
Actins
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metabolism
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Antigens, CD
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metabolism
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Antigens, Differentiation, Myelomonocytic
;
metabolism
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Diagnosis, Differential
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Female
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Granuloma, Plasma Cell
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metabolism
;
pathology
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Histiocytoma, Benign Fibrous
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diagnostic imaging
;
metabolism
;
pathology
;
surgery
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Humans
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Lung Neoplasms
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diagnostic imaging
;
metabolism
;
pathology
;
surgery
;
Middle Aged
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Neprilysin
;
metabolism
;
Pneumonectomy
;
methods
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Radiography
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Sarcoma
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metabolism
;
pathology
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Solitary Fibrous Tumors
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metabolism
;
pathology
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Vimentin
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metabolism
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Xanthomatosis
;
metabolism
;
pathology
3.Low-grade central osteosarcoma: a clinicopathologic analysis of nine cases.
Hong YU ; Hui LI ; Chao-Fu WANG ; Xiong-Zeng ZHU
Chinese Journal of Pathology 2010;39(11):762-766
OBJECTIVEto study the clinicopathologic features and differential diagnosis of low-grade central osteosarcoma (LGCOS).
METHODSnine cases of LGCOS were retrieved from the archival consultation files. The clinical, radiologic and pathologic features were analyzed, with literature review.
RESULTSthe mean age of the patients was 31 years. The male-to-female ratio was 3:6. All of the patients presented with painful mass and/or swelling. The sites of involvement included thigh (n = 4), tibia (n = 1), fibula (n = 1), cervical vertebra (n = 1), lumbar vertebra (n = 1) and maxilla (n = 1). Radiologic examination showed mixed lytic/blastic lesions with soft tissue shadow in 5 cases and associated periosteal reaction in 3 cases. The tumors were treated by surgical excision, with no adjuvant therapy given. The duration of follow up ranged from 2 to 43 months. Four cases had recurrence which occurred at 8 to 25 months after the operation. Gross examination showed that the tumors were fragmented on submission in 5 cases and en bloc in 4 cases. They had solid and firm cut surface, with various degree of grittiness. Histologically, LGCOS was characterized by the presence of hypocellular fibroblastic stroma associated with focal osteoid production. The spindly tumor cells showed mild degree of nuclear pleomorphism, with occasional mitotic figures demonstrated in all of the 9 cases. The newly formed neoplastic woven bone did not have any osteoblastic rimming. The bony trabeculae were slender and seam-like. Parallel arrays of woven bone were seen in 6 cases. Some of the bony trabeculae appeared irregularly branched and curved. The tumor cells permeated adjoining pre-existing bony trabeculae and bone marrow in all cases. Three cases also showed soft tissue involvement.
CONCLUSIONSLGCOS often posses important diagnostic pitfalls due to the relatively bland-looking tumor cell morphology and associated large woven or longitudinal seams of lamellar-like bone. Thorough understanding of the histologic features, when coupled with clinical and radiologic findings, are essential in arriving at a correct diagnosis.
Adolescent ; Adult ; Bone Neoplasms ; diagnostic imaging ; pathology ; surgery ; Diagnosis, Differential ; Female ; Fibrous Dysplasia of Bone ; pathology ; Fibula ; diagnostic imaging ; Histiocytoma, Benign Fibrous ; pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Osteosarcoma ; diagnostic imaging ; pathology ; surgery ; Radiography ; Radionuclide Imaging ; Reoperation ; Thigh ; diagnostic imaging ; pathology ; Young Adult