OBJECTIVETo study the clinicopathological features of primary splenic histiocytic sarcoma.

METHODSClinicopathological characterstics were analyzed in a case of primary splenic histiocytic sarcoma and related literatures were reviewed.

RESULTSA 69-year old woman had unexplained debility and palpitation after exertion for a month. CT showed splenomegaly with multiple occupancy. The resected spleen measured 28 cm × 18 cm × 10 cm. Histopathological examination demonstrated that the neoplastic cells diffusely infiltrated splenic sinus. The neoplastic cells were characterized by well-defined cell contour, large pleomorphic nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. Tumor cells with cytoplasmic vacuoles and intense hemophagocytosis were observed. These cells strongly expressed histiocytic markers CD68 and CD163. Immunostaining for LCA, Vim was positive, but negative for CD1a, S-100, CD30, CK, CD20, CD3, CD21.

CONCLUSIONSImmunohistochemistry plays a key role in the diagnosis of primary splenic histiocytic sarcoma.

No abstract available.
Bone Marrow* ; Histiocytic Sarcoma*

No abstract available.
Granuloma, Plasma Cell* ; Histiocytic Sarcoma*

Histiocytic Sarcoma ; diagnosis ; pathology ; therapy ; Humans ; Infant, Newborn ; Male

Adult ; Hepatitis, Viral, Human ; complications ; Histiocytic Sarcoma ; complications ; Humans ; Male

Child, Preschool ; Histiocytic Sarcoma ; pathology ; therapy ; Humans ; Lymphatic Metastasis ; Male

Two cases of malignant histiocytosis, in which skin involvement was a prominent finding at initial clinical presentation, are reported. 1nteresting histopathologic findings, including Langerhans granule in one case and numerous eosinophils in another, were observed. In one case remission was achieved with BACOP chemotherapy (Bleomycin, Adriamycin, Cyclophosphamide, Vincristine, and Prednisone). In the other case, the patient died nine months after the onset of the disease without any treatment.
Cyclophosphamide ; Doxorubicin ; Drug Therapy ; Eosinophils ; Histiocytic Sarcoma* ; Humans ; Skin ; Vincristine

Head and neck sarcomas account for about 1% of malignant head and neck tumors, and histiocytic sarcomas (HSs) account for less than 1% of all hematolymphoid neoplasms. These rare hematopoietic neoplasms are the result of a malignant proliferation of cells. They have morphological and immunophenotypic features of mature tissue histiocytes, which play a major role in processing and presenting antigens to T or B lymphocytes. The mesenchymal differentiation of HSs has not been reported. We describe a case of HS with rhabdoid differentiation in a 55-year-old man who presented with a 3×2.5×2 cm mass in the left supraclavicular area. To the best of our knowledge, this is the first report worldwide of a primary HS with rhabdoid differentiation.
B-Lymphocytes ; Head* ; Hematologic Neoplasms ; Histiocytes ; Histiocytic Sarcoma* ; Humans ; Middle Aged ; Neck* ; Sarcoma

Aged ; Female ; Histiocytic Sarcoma ; diagnosis ; pathology ; Humans ; Skin ; pathology ; Skin Neoplasms ; diagnosis ; pathology

Histiocytic sarcoma in the liver is an extremely rare hematological malignancy. Herein, we reported the case of a 68-year-old woman who presented with characteristic wedge-shaped abnormality bounded by hepatic veins on computed tomography and magnetic resonance imaging of the liver. In the wedge-shaped area, decreased portal flow and the deposition of iron were observed. These imaging findings are consistent with intrasinusoidal tumor cell infiltration. A liver biopsy was performed, and histiocytic sarcoma was confirmed histopathologically.
Aged ; Biopsy ; Female ; Hematologic Neoplasms ; Hepatic Veins ; Histiocytic Sarcoma* ; Humans ; Iron ; Liver ; Magnetic Resonance Imaging*