1.Peri-orbital electrodes as a supplemental recording for detection of ictal discharges in medial temporal lobe epilepsy
Hiroshi Shigeto ; Ayumi Sakata ; Takato Morioka ; Kei-ichiro Takase ; Ko-ichi Hagiwara ; Takashi Kamada ; Yuji Kanamori ; Kimiaki Hashiguchi ; Shozo Tobimatsu ; Natsumi Yamashita ; Jun-ichi Kira
Neurology Asia 2011;16(4):303-307
Objective: The feasibility of peri-orbital electrodes, which are not invasive and do not induce pain, as a
supplemental electrode for detection of ictal discharges in medial temporal lobe epilepsy (MTLE) was
examined. Methods: Patients with MTLE, who underwent video-EEG monitoring with simultaneous
peri-orbital and sphenoidal electrodes and obtained good outcome following standard anterior temporal
lobectomy, were subjects in this study. Initial ictal discharge amplitudes were compared between
sphenoidal (Sp1/ 2), standard anterior temporal in 10-20 system (F7/ 8), peri-orbital (superior orbital
lateral: SOL, inferior orbital medial: IOM), frontopolar (Fp1/ 2), frontal (F3/4) and ear (A1/ 2) electrodes.
Results: A total of 34 consecutive seizures from 20 patients were analyzed, with a maximum amplitude
observed at Sp1/2 (57.57±5.59), followed by F7/8 (54.89±5.59), SOL (50.97±5.59), IOM (46.95±5.59),
A1/2 (45.07±5.69), Fp1/2 (44.78±5.62), and F3/4 (37.75±5.66) (mean±standard error, μV). There was
no statistical difference between Sp1/2, F7/8, SOL, and IOM values. When the sphenoidal electrode
was omitted, 13 seizures (13/34, 38.2%) resulted in the highest amplitude at peri-orbital electrodes
and 10 seizures (10/ 34, 29.4%) at F7/8.
Conclusions: Peri-orbital electrodes could detect ictal discharges in MTLE as well as sphenoidal and
standard anterior temporal electrodes in 10-20 system and are useful for supplemental recording for
detecting ictal epileptiform discharges in MTLE.
2.Genomic Profiling Shows Increased Glucose Metabolism in Luminal B Breast Cancer.
Shigeto UEDA ; Toshiaki SAEKI ; Hideki TAKEUCHI ; Takashi SHIGEKAWA ; Kazuo MATSUURA ; Noriko NAKAMIYA ; Hiroshi SANO ; Hiroko SHIMADA ; Eiko HIROKAWA ; Akihiko OSAKI
Journal of Breast Cancer 2013;16(3):342-344
We had previously reported a close association between pathological response and the maximum tumor standardized uptake value (SUVmax) measured by 18F-fluorodeoxyglucose positron emission tomography prior to chemotherapy in estrogen receptor (ER)-positive breast cancer. We hypothesized that glucose hypermetabolism by luminal B tumors may result in chemotherapy responsiveness. Using a single-gene expression assay, TargetPrint(R) (Agendia) and a 70-gene expression classifier, MammaPrint(R) (Agendia), we divided 20 patients with ER-positive primary breast cancer into luminal A and luminal B subtypes and compared the tumor SUVmax value between the two groups. A significantly higher SUVmax was measured for luminal B tumors (n=10; mean+/-SD, 7.6+/-5.6) than for luminal A tumors (n=10; mean+/-SD, 2.6+/-1.2; p=0.01). Glucose hypermetabolism could help predict intrinsic subtyping and chemotherapy responsiveness as a supplement to ER, progesterone receptor, HER2, and Ki-67 histochemical scores.
Breast
;
Breast Neoplasms
;
Estrogens
;
Glucose
;
Humans
;
Phenobarbital
;
Positron-Emission Tomography
;
Receptors, Progesterone