1.Penidioxolanes A and B, 1,3-Dioxolane Containing Azaphilone Derivatives from Marine-derived Penicillium sp. KCB12C078.
Seung Min KIM ; Sangkeun SON ; Jong Won KIM ; Eun Soo JEON ; Sung Kyun KO ; In Ja RYOO ; Kee Sun SHIN ; Hiroshi HIROTA ; Shunji TAKAHASHI ; Hiroyuki OSADA ; Jae Hyuk JANG ; Jong Seog AHN
Natural Product Sciences 2015;21(4):231-236
Two new azaphilone derivatives containing 1,3-dioxolane moiety, penidioxolanes A (1) and B (2), were isolated from marine-derived fungus Penicillium sp. KCB12C078, together with four known compounds (3-6) by chemical investigation. Compounds 1 - 6 were isolated by combination of silica gel, ODS column chromatography and preparative HPLC. Their structures were determined by analysis of spectroscopic data including 1D-, 2D-NMR, and MS techniques. The isolates were evaluated against cancer cell growth inhibition effects and antimicrobial activity.
Chromatography
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Chromatography, High Pressure Liquid
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Fungi
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Penicillium*
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Silica Gel
Result Analysis
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