Six male and seven female children, aged five or six years, ran on the flat treadmill increasing running speeds every two minutes by 20 m/min till their subjective exhaustions. The first steps were started with the speeds of 80 or 100 m/min and the rest periods of 30 seconds were inserted between each successive step for the blood sampling. Expired airs for the determination of oxygen uptakes were collected during the last 30 seconds of every stage. Heart rates were recorded for each subject throughout the whole test session.
Two male and two female subjects were selected in order to determine their physical activity levels in the nursery school. Their heart rates were recorded from Monday to Saturday in a given week.
Analyses of physical activity patterns were tried by relating heart rate levels to circulorespiratory variables which were equivalent to 3 or 4 mmol/l blood lactate concentration (3m MLA or 4m MLA) .
By so doing, the following results were obtained:
1) Mean values of blood lactate concentrations observed immediately after the cessation of the last exhaustive steps were 5.16 m MLA for males and 4.70 m MLA for females.
2) Relative values of heart rate to 3 and 4 m MLA against maximal heart rate (% HRmax-3 m MLA and % HRmax-4 m MLA) were respectively 92.2% HRmax-3 m MLA and 97.5% HRmax-4m MLA for males and 94.9% HRmax-3 m MLA and 98.2% HRmax-4 m MLA for females.
The corresponding relative values of oxygen uptakes were 85.2% Vo₂max-3 m MLA and 94.3% Vo₂max-4 m MLA for males and 89.7% Vo₂max-3 m MLA and 96% Vo₂max-4 m MLA for females.
3) Mean values of heart rate recorded in the nursery through a given week except Sunday ranged from 89 to 114 beats/min for males and 106 to 126 beats/min for females. In the relative value of a heart rate against the heart rate equivalent to 4 m MLA, that is, HR 4 m MLA these values correspond to 44-57% HR 4 m MLA and 57-67% HR 4 m MLA respectively.
4) Accumulated duration time: Their hearts beat higher than 160 beats/min, except in the case of 800 m endurance run (only 0-4 and 0-6 minutes for males and 0-6 and 4-21 (touch of tachycardia) minutes for females) .
Percentages of accumulated duration time lower than 120 beats/min occupied 72-94% and 77-91% of 6 or 7-hour nursing time for males and 51-91% and 51-78% for females.
5) Absolute and relative values of mean heart rates in 800 m endurance run ranged from 183 beats/min (Net 83% HRmax, 90% HR 4 m MLA) to 199 beats/min (Net 98% HRmax, 104% HR 4 m MLA) for males and from 172 beats/min (Net 77% HRmax, 92% HR 4 m MLA) to 196 beats/min (Net 92% HRmax, 96% HR 4 m MLA), though the duration times were short.
6) Optimal intensity of work load was proposed to be the heart rate level of at least 190 beats/min for favourable development and/or improvement of the circulo-respiratory system in young children.

Twelve young boys as an experimental group and seven as a control group, aged 5-6 years, participated in a study to clarify whether circulorespiratory trainability exists in young children. The subjects in the experimental group performed a 915 m endurance run on an agricultural road every day except Sundays for six months. During the run, heart rates (HR) equivalent to 3-4 mmol⋅l^-1 of blood lactate concentration (LA) were maintained for at least 3-4 min⋅m^-1. The control group was given no special training.
Before and after the training period, both groups were subjected to increased stepwise running velocity on a flat treadmill till subjective exhaustion to determine circulorespiratory variables such as heart rate (HR), oxygen uptake (Vo₂) and blood lactate concentration (LA) at all steps.
From the above mentioned procedure, the following findings were obtained :
1) After the 6-month endurance run training, Vo₂max/TBW was significantly (p<0.05) increased from 47.5 to 50.4 ml⋅kg^-1⋅min^-1 and also the peak LA was significantly (p<0.05) increased from 5.41 to 6.36 mmol⋅l^-1in the experimental group. On the other hand, no significant increases were observed in the control group.
2) Running velocity in the final stages (Vmax) was significantly (p<0.001) improved from 190.0 to 205.0 m⋅min^-1in the experimental group. Such effects were due partly to the improvement of circulorespiratory function and partly to improved efficiency of running motion. However, no significant differences were found in the control group.
3) Submaximal V, HR, and Vo₂/TBW equivalent to 3 and 4 mmol⋅l^-1 and their values relative to the maximum values showed no significant differences before and after the training period in both groups. The improvement of maximal circulorespiratory variables observed in the experimental group suggests the existence of trainability even in young children.

Eight young girls as an experimental group (E group) and another eight as a control group (C group), (all aged 4-5 years), participated in the present study to observe the effects of training from May 1992 through November 1993. E group performed a 915m endurance run on an agricultural road every day except Sundays for an 18 month training period. No special training was given to C group. In May 1992 (T 1), November 1992 (T 2), May 1993 (T 3), and November 1993 (T 4), both groups underwent treadmill tests in order to check aerobic variables such as heart rate (HR) and oxygen uptake (VO₂) during the course of the training period.
Times required for the run became shorter from summer to fall and from winter to spring (shortening phase), whereas they became prolonged from spring to summer and from fall to winter (prolongation phase) . Therefore, there was a definite seasonality of performance endurance. The rates of shortening in the required times observed from summer to fall were considerably higher than from winter to spring, and this was reflected in the significant improvement of maximal running speed on the treadmill (Vmax) and maximal oxygen uptake in terms of body weight (VO₂max⋅ TBW^-1) from T 1 to T 2 as well as from T 3 to T 4. Thus, significant differences were found between the groups at T 2 and T 4. HR levels during the endurance run were close to 95% HRmax regardless of the phase. Accordingly, the prolongation phases, during which circulatory parameters and ventilatory capacity were least improved, could be regarded as a preparatory period for the following shortening period, during which work load intensities furthermore increased the arteriovenous oxygen differences. Thus, when planning research on the effects of training on aerobic work capacity in the field, special attention should be paid to the season and the training period, and the timing of the examination for training effects, or otherwise, misleading conclusions could be drawn.

In order to find out the criteria for the determination of maximal oxygen uptakes of very young children, five boys and five girls, aged four or five years, served as the subjects. They ran on the horizontal treadmill once a day for the constant three minutes on different days. The velocity was increased from the first 100m/min by 20m/min till the last where they could endure no longer for the three minutes. As the consequence, the velocities attained were 100m/min, 120m/min, 140m/min, 160m/min, 180m/min and 200m/min for boys and 100m/min, 120m/min, 140m/min, 160m/min and 180m/min for girls.
The expired airs were collected at rest and whole through the treadmill running.
Heart rates were also continuously registered not only at rest but also during the treadmill running.
The following results were obtained:
1) At the velocities of 100m/min, 120m/min and 140m/min apparent steady states of heart rates and Vo₂ were established within the three miuntes both for boys and girls.
But boys showed lower heart rates and higher Vo₂ during the steady states at a given velocity than girls did.
2) At the last velocity of 200m/min Vo₂max were attained 30 seconds after the start of running for boys and also at the last of 180m/min girls reached Vo₂max 60 seconds after the beginning.
It was, therefore, confirmed that if the work intensity was sufficiently high, Vo₂ max could be reached at the latest between 30 and 60 seconds after the start of work for young children.
3) At the one step lower velocity than the last, namely, 180m/min for boys and 160m/min for girls, the plateaus of Vo₂max were found for the last minute.
4) The heart rates simultaneously observed with Vo₂max ranged from 202.4 to 206.4 bpm and also RQ were all above the unit. Accordingly these values could be regarded as the most important critieria for the evaluation of aerobic work capacity of young children.
5) When the velocity was high, the respiratory frequency sharply rises immediately after the start of running. For the first thirty seconds the breath rates reached 60 to 90/min.
6) If the duration of the running on the horizontal treadmill are constantly fixed three minutes, the upper limit of the velocity where the safe aerobic steady state can be established is 140m/min both for boys and girls.

Purpose: With the aim of improving the efficiency of smoking cessation treatment, we analyzed and classified various factors to identify the relationships between the background of patients and effects of treatment, and examine their characteristics.
Methods: We conducted a questionnaire survey to collect information on the situation of patients, and obtained their treatment data from medical records.  Decision tree analysis, a data mining method, was employed to examine these data.
Results: According to the results of the survey, the smoking cessation rate was 80.4%.  The rate was associated with CO concentrations in the breath at the initial examination, nicotine content in cigarettes smoked by patients, and the daily and total number of cigarettes smoked.  The smoking cessation rate among patients under emotional stress was 76.2%; the rate was higher when patients were able to reduce their mental stress levels.
Conclusion: We identified characteristic relationships between the background of patients and the effects of treatment, and they proved to be useful for the improvement of the smoking cessation rate.

Objective: From September 2009, the Department of Pharmacy of Kitasato University Kitasato Institute Hospital started operation room services, and the pharmacist in charge also responds to the inquiries from the operation room staff (doctors and nurses) concerning pharmaceutical compounds.  In the present study, we collected the inquiries and analyzed their contents in order to understand the information of pharmaceutical compounds required by the operation room staff.
Methods: The inquiries from operation room staff received between October 2009 and March 2012 were collected and the contents were analyzed.
Results: A total of 625 inquiries (mean, 20.8 inquiries per month) were received.  Regarding the contents of inquiry, the most frequent inquiry was on “the presence or absence of the stock” (70.7%), followed by “drug information” (17.0%), “handling of controlled substances” (5.9%), and “handling of non-controlled substances” (4.2%).  For “the presence or absence of the stock,” the most common pharmaceutical compounds inquired were antibacterial agents, anesthetics, and infusion fluids.  For “drug information,” the contents were diverse, ranging from drug efficacy to operation method, whether compounds are included in hospital drug list, in-hospital preparations, and drug selection.  For “handling of non-controlled substances,” the most frequent inquiries were associated with the expiration date after unsealing.
Conclusion: The most frequent inquiry from the operation room staff was on “the presence or absence of the stock,” and the common subject of inquiry was presumably pharmaceutical compounds frequently used at the time of surgery.  The analysis showed that the operation room requires a wide range of information.

Seventy patients with liver cirrhosis hospitalized into our clinic were divided into a compensatory group and a decompensatory group according to three clinical findings, ascites, hepatic encephalopathy and bleeding from gastrointestinal tract. It was suggested that five items of biochemical data for liver function were very important on discriminating these two grops. The five items were cholinesterase, indocyanine green test, albumin, prothrombin time and hematocrit.
We have tried to devise a new staging system for liver cirrhosis by scoring method using the five items. According to the total score calculated from scoring method, clinical stages were divided into four such as stage I, stage II, stage III, and stage IV. It was suggested that cases of stage III had to be treated very carefully.
Liver and spleen volume of patients with liver cirrhosis were calculated by computed tomography. It was suggested that liver volume/spleen volume ratio was very important on discriminating these two groups.

With aging of inpatients, the prevention of falls in old people is an important task nurses have to take upon themselves. In our hospital, we have been tackling the task in earnest by utilizing a fall prevention assessment score sheet. Our efforts have resulted in changes in the attitude of nurses as shown by a survey. (1) By working on the nursing plan with use of the fall prevention assessment score sheet, nurses have become alert to risk factors for falling. (2) They have realized that assistance suited to the needs of each patient is vital and that collaboration between patients, their families and hospital staff contributes to the prevention of falls greatly. (3) The use of an intervention manual has made it easy for nurses to cope with falls and consequent injury. (4) To share information of every factor for falling among the nursing staff has added greatly to the prevention of the recurrence of the fall.
Prevention ; Fall, NOS ; Surveys ; Attitude ; Knowledge acquisition using a method of assessment

We aimed to assess whether patients with hemifacial microsomia can be quantitatively identified using bone mineral density information. Mandibular bone mineral density was studied using computer assisted analysis between the nonaffected (r) and the affected (l) sides with an orthopantomograph in a patient with hemifacial microsomia with median mandibular cleft, and four patients who suffered from hemifacial microsomia in the left side. Fifty controls without bone diseases were randomly selected. Bone mineral density r/l ratios in the controls ranged from 0.479 to 2.064, and those in two patients that were associated with and without median mandibular cleft were higher than those in the controls, with a maximum of 8.622 in a particular male with median mandibular cleft after bone graft, whereas the r/l ratios in the other three cases were similar to the controls. Our findings indicate that the quantitative character in the case with median mandibular cleft reveals a large discrepancy of bone mineral density between the nonaffected and the affected sides. This may suggest a compensatory mechanism for bone hypertrophy from regulated bone mineral density with underdevelopment in hemifacial microsomia.