1.The Use of Magnesium Sulfate in Tetanus Treatment
Hiroki YASUHARA ; Atsushi KAWASHIMA ; Mikio WADA ; Akiko HANAMOTO ; Natsuko KAKU
An Official Journal of the Japan Primary Care Association 2021;44(2):53-58
Introduction: Tetanus is a highly fatal infection that causes tonic convulsions. Although magnesium sulfate may be effective as a treatment option for myopathic symptoms, there is little knowledge regarding its use. Therefore, this study assessed the use of magnesium sulfate for patients with tetanus requiring critical care management.Methods: Using multiple mailing lists of registered physicians in Japan, a questionnaire survey was conducted on the conditions during which magnesium sulfate was used for patients with tetanus requiring critical care management. An internet questionnaire form service was utilized.Results: The number of targets in this study was 24,266 and responses were received from 604 physicians, 252 of whom treated patients with tetanus requiring critical care management. In total, 126 of the above physicians used magnesium sulfate for tetanus.Conclusion: Magnesium sulfate was used for a substantial number of patients with tetanus requiring critical care management. To establish the utility of magnesium sulfate as a tetanus treatment option, further evidence is required.
2.Seven days triple therapy for eradication of Helicobacter pylori does not alter the disease activity of patients with inflammatory bowel disease.
Shinichiro SHINZAKI ; Toshimitsu FUJII ; Shigeki BAMBA ; Maiko OGAWA ; Taku KOBAYASHI ; Masahide OSHITA ; Hiroki TANAKA ; Keiji OZEKI ; Sakuma TAKAHASHI ; Hiroki KITAMOTO ; Kazuhito KANI ; Sohachi NANJO ; Takeshi SUGAYA ; Yuko SAKAKIBARA ; Toshihiro INOKUCHI ; Kazuki KAKIMOTO ; Akihiro YAMADA ; Hisae YASUHARA ; Yoko YOKOYAMA ; Takuya YOSHINO ; Akira MATSUI ; Misaki NAKAMURA ; Taku TOMIZAWA ; Ryosuke SAKEMI ; Noriko KAMATA ; Toshifumi HIBI
Intestinal Research 2018;16(4):609-618
BACKGROUND/AIMS: The influences of Helicobacter pylori eradication therapy on the disease course of inflammatory bowel disease (IBD) are still unclear. We therefore conducted a multicenter, retrospective cohort study to evaluate the safety of H. pylori eradication therapy for IBD patients. METHODS: IBD patients with H. pylori eradication from 2005 to 2015 (eradication group) and control patients (non-eradication group; 2 paired IBD patients without H. pylori eradication matched with each eradicated patient) were included. IBD exacerbation (increased/additional IBD drug or IBD-associated hospitalization/surgery) and disease improvement based on the physicians’ global assessment were investigated at baseline, and at 2 and 6 months after eradication or observation. RESULTS: A total of 429 IBD (378 ulcerative colitis, 51 Crohn’s disease) patients, comprising 144 patients in the eradication group and 285 patients in the non-eradication group, were enrolled at 25 institutions. IBD exacerbation was comparable between groups (eradication group: 8.3% at 2 months [odds ratio, 1.76; 95% confidence interval, 0.78–3.92; P=0.170], 11.8% at 6 months [odds ratio, 1.60; 95% confidence interval, 0.81–3.11; P=0.172]). Based on the physicians’ global assessment at 2 months, none of the patients in the eradication group improved, whereas 3.2% of the patients in the non-eradication group improved (P=0.019). Multivariate analysis revealed that active disease at baseline, but not H. pylori eradication, was an independent factor for IBD exacerbation during 2 months’ observation period. The overall eradication rate was 84.0%–comparable to previous reports in non-IBD patients. CONCLUSIONS: H. pylori eradication therapy does not alter the short-term disease activity of IBD.
Clarithromycin
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Cohort Studies
;
Colitis, Ulcerative
;
Helicobacter pylori*
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Helicobacter*
;
Humans
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Inflammatory Bowel Diseases*
;
Metronidazole
;
Multivariate Analysis
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Retrospective Studies