1.The Roles and Limitations of Psychiatric Department without Beds at General Hospital in Emergency Cases. Retrospective Investigation of Consultation-Liaison Services in Intensive Care Unit(ICU).
Journal of the Japanese Association of Rural Medicine 2001;50(4):625-631
JA Hiroshima General Hospital has 578 beds, and the Psychiatric Department, founded in 1994, is staffed with two doctors without beds. On June 1, 1999, the Intensive Care Unit (ICU) was newly established in the hospital. Forty-two inpatients in the ICU were referred to us during the one-year period following the establishment of the ICU in our hospital. We investigated the reasons for consultation, somatic and psychiatric diagnoses, and outcome, and compared our findings with the results of the surveys conducted by other hospitals with psychiatric units. Our investigation revealed that “suicide attempt or suicidal ideation” was highest on the list of reasons for consultation, “acute drug intoxication” was highest on the list of medical diagnoses, “adjustment disorder” was highest on the list of psychiatric diagnoses, and that “discharged from ICU” was highest of outcomes. Compared with other reports, we had small percentages of “treatment for combined medical and psychiatric illness” among the reasons for consultation, and “schizophrenia” among psychiatric diagnoses, while we had higher percentages of “adjustment disorder” among psychiatric diagnoses, and “being transferred from the ICU to a medical ward” among outcomes, In view of the riskmanagement program at the hospital, we often felt there is difficulty treating physical diseases in psychiatric patients, especially patients who have made suicide attempts in medical wards. Therefore, we consider triage may be one of the most important functions of a psychiatic department without beds. To coordinate our roles successfully, it is necessary to build an effective network with other psychiatric institutions.
3.Testosterone Replacement Therapy for Patients with Hypogonadism after High Dose-Rate Brachytherapy for High-Risk Prostate Cancer: A Report of Six Cases and Literature Review
Suguru KADOMOTO ; Kazuyoshi SHIGEHARA ; Hiroaki IWAMOTO ; Hiroshi YAEGASHI ; Kouji IZUMI ; Yoshifumi KADONO ; Atsushi MIZOKAMI
The World Journal of Men's Health 2020;38(1):132-136
4.Significance of PD-L1 expression in carbon-ion radiotherapy for uterine cervical adeno/adenosquamous carcinoma
Moito IIJIMA ; Noriyuki OKONOGI ; Nakako Izumi NAKAJIMA ; Yukie MOROKOSHI ; Hiroaki KANDA ; Taiju YAMADA ; Yusuke KOBAYASHI ; Kouji BANNO ; Masaru WAKATSUKI ; Shigeru YAMADA ; Tadashi KAMADA ; Daisuke AOKI ; Sumitaka HASEGAWA
Journal of Gynecologic Oncology 2020;31(2):19-
OBJECTIVE: Programmed cell death-ligand 1 (PD-L1) is expressed in tumor cells and has been shown to predict clinical outcomes of several types of malignancies. The aim of this study was to investigate the effects of carbon-ion (C-ion) beam irradiation on PD-L1 expression in human uterine cervical adeno/adenosquamous carcinoma (UCAA) cells and clinical samples and to identify the prognostic factors for outcomes after C-ion radiotherapy (CIRT).METHODS: The effects of C-ion irradiation on PD-L1 expression in human UCAA and cervical squamous cell carcinoma cells were examined by flow cytometry. We examined PD-L1 expression in UCAA biopsy specimens from 33 patients before CIRT started (pre-CIRT) and after 12 Gy (relative biological effectiveness [RBE]) irradiation (post-12Gy-C) in 4 fractions of CIRT to investigate the correlation between PD-L1 status and clinical outcomes.RESULTS: The PD-L1 expression was upregulated by C-ion beam in a dose-dependent manner in HeLa and SiHa cells through phosphorylated Chk1. The overall frequencies of pre-CIRT and post-12Gy-C PD-L1 positivity were 45% (15/33) and 67% (22/33), respectively. The post-12Gy-C PD-L1 expression was significantly elevated compared to the pre-CIRT PD-L1 expression. There was no significant relationship between the pre-CIRT PD-L1 status and clinical outcomes, such as local control (LC), progression-free survival (PFS), and overall survival (OS). However, the post-12Gy-C PD-L1 expression had better correlation with PFS, but not with LC and OS.CONCLUSION: CIRT can induce PD-L1 expression in UCAA and we propose that PD-L1 expression after starting CIRT may become as a predictive prognostic marker in CIRT for UCAA.
Antigens, CD274
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Biopsy
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Carcinoma, Squamous Cell
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Disease-Free Survival
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Flow Cytometry
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Heavy Ion Radiotherapy
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Humans
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Radiotherapy
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Treatment Outcome
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Uterine Cervical Neoplasms
5.Significance of PD-L1 expression in carbon-ion radiotherapy for uterine cervical adeno/adenosquamous carcinoma
Moito IIJIMA ; Noriyuki OKONOGI ; Nakako Izumi NAKAJIMA ; Yukie MOROKOSHI ; Hiroaki KANDA ; Taiju YAMADA ; Yusuke KOBAYASHI ; Kouji BANNO ; Masaru WAKATSUKI ; Shigeru YAMADA ; Tadashi KAMADA ; Daisuke AOKI ; Sumitaka HASEGAWA
Journal of Gynecologic Oncology 2020;31(2):e19-
OBJECTIVE:
Programmed cell death-ligand 1 (PD-L1) is expressed in tumor cells and has been shown to predict clinical outcomes of several types of malignancies. The aim of this study was to investigate the effects of carbon-ion (C-ion) beam irradiation on PD-L1 expression in human uterine cervical adeno/adenosquamous carcinoma (UCAA) cells and clinical samples and to identify the prognostic factors for outcomes after C-ion radiotherapy (CIRT).
METHODS:
The effects of C-ion irradiation on PD-L1 expression in human UCAA and cervical squamous cell carcinoma cells were examined by flow cytometry. We examined PD-L1 expression in UCAA biopsy specimens from 33 patients before CIRT started (pre-CIRT) and after 12 Gy (relative biological effectiveness [RBE]) irradiation (post-12Gy-C) in 4 fractions of CIRT to investigate the correlation between PD-L1 status and clinical outcomes.
RESULTS:
The PD-L1 expression was upregulated by C-ion beam in a dose-dependent manner in HeLa and SiHa cells through phosphorylated Chk1. The overall frequencies of pre-CIRT and post-12Gy-C PD-L1 positivity were 45% (15/33) and 67% (22/33), respectively. The post-12Gy-C PD-L1 expression was significantly elevated compared to the pre-CIRT PD-L1 expression. There was no significant relationship between the pre-CIRT PD-L1 status and clinical outcomes, such as local control (LC), progression-free survival (PFS), and overall survival (OS). However, the post-12Gy-C PD-L1 expression had better correlation with PFS, but not with LC and OS.
CONCLUSION
CIRT can induce PD-L1 expression in UCAA and we propose that PD-L1 expression after starting CIRT may become as a predictive prognostic marker in CIRT for UCAA.
6.A novel screening strategy for clinically significant prostate cancer in elderly men over 75 years of age.
Hiroaki IWAMOTO ; Kouji IZUMI ; Suguru KADOMOTO ; Tomoyuki MAKINO ; Renato NAITO ; Hiroshi YAEGASHI ; Kazuyoshi SHIGEHARA ; Yoshifumi KADONO ; Atsushi MIZOKAMI
Asian Journal of Andrology 2021;23(1):36-40
A standard modality for prostate cancer detection in men 75 years and older has not been established. A simple screening method for elderly patients is needed to avoid unnecessary biopsies and to effectively diagnose prostate cancer. A retrospective study was conducted on elderly patients who had prostate biopsy at Kanazawa University Hospital (Kanazawa, Japan) between 2000 and 2017. Of the 2251 patients who underwent prostate biopsy, 254 had clinically significant prostate cancer (CSPC) with a Gleason score (GS) of≥7 and 273 had a GS of <7 or no malignancy. In this study, patients aged 75 years or older were classified as elderly patients. GS ≥ 7 was characterized by a prostate-specific antigen (PSA) of the maximum area under the curve of 12 ng ml