Acute promyelocytic leukaemia (APML) is characterised by the t(15;17)(q22;q21), that results in
the fusion of the promyelocytic leukaemia (PML) gene at 15q22 with the retinoic acid α-receptor
(RARA) gene at 17q21. The current case report describes a 13-year-old male with APML, who
was negative for PML/RARA fusion signal but reported to have an atypical translocation t(16;17).
To the best of our knowledge this is the first case report of APML responsive to ATRA with such
a translocation.
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