Study on the use of caprylic acid in the purification of anti rabies serum. The use of coprylic acid (octanoic) in the cleaning process IgG from horse plasma was studied to apply in the purification of anti rabies serum in the Institute of Vaccine and Biological Substances. When using caprylic acid in the purification of serum, the quality and quantity of the products were improved. The purity and colour of product was managed as desire. The process had a high effectiveness and short time of purification
Caprylic acid ; Rabies

During last 2 decades, the need of new generation vaccine from encapsulated bacterial polysaccharide for preventing typhoid, pneumonia, Hib and menigococcal diseases… rose. Chemical vaccine has high safety, efficiency even in young children. Polysaccharide (conjugated) and making an ability to combine different antigens could prevent many diseases. This is the right way to reduce the times of injection and lower the prices to serve well
vaccines ; Radiation

The supplementation of oligo-alginate with molecular weight of 4.700 Dalton at the concentration of 30-50 ppm has made the biomass of Bacillus subtilis increased visibly.
bacillus subtilis ; bacteria ; water

The diagram of immune system with antigene was the toxic extract from the repeating stage, making the rough serum up to the lowest of 150 Lf/ml (or 210IU/ml) and applied the method of taking horse’s blood and giving back red blood cells to increase the the rough serum two times. The new process did reduce the level fN-protein, time and increase the quantity and productivity of the purified serum. The purified serum was of high quality: clear color, low level of N-protein to 30% compared with registered standard (150mg/ml).
Tetanus Antitoxin ; Serum

The Institute of Vaccine had elaborated a procedure of preapration and produced successfully a 4 component liquid vaccine of diphteria – tetanos – coqueluche and meningitis (DTP-Hib). The quality have reached the standards issued in European and WHO Pharmacopoeia. The procedure of preparation of DPT-Hib mixt vaccine and the preliminary procedure of its quality control were established
Vaccines ; Diphtheria ; Tetanus ; Whooping Cough

The Institute of Vaccine and Biologicals has recently released on market a purified tetanus antitoxin. The average potency of the product reached  3.000 IU/ml. The N-protein content is  70mg/ml
Tetanus Antitoxin ; Diseases ; Tetanus

In the last 11 years recently the contaminated rate was very low (291/6382 samples). 0.45% and decreased dramatically in the past 3 years (2000-2003 period). The most common contaminated germs were primarily gram(+) bacteria (60% - 195/320 samples). 4.6% of samples were contamined with fungi (15/320), which should be erradicated completely
Biochemistry ; Bacillus subtilis ; Probiotics

Selection of bacteria classification, collection the normal groups in sterility of vaccine and substances of national Institute of Vaccines (IVAC) of Nha Trang - Da Lat during 20 years (from 1983 to 2003). Cultured environment thioglycolate and Sabouraud. Gram's stain method and recognized and biochemical test were applied routinely by WHO. A computer software based on bacteria classification and SQL language in MS Access were developed by IVAC. This program was used for controlling sterility of vaccine and substances to follow GMP requirement in the future
Infertility ; Vaccines ; Software ; classification

Rabies is a common contagious disease of human and animals (dog, cat, monkey...) that caused by a virus. In Vietnam, normally every year has from 300 to 500 people die of rabies (equally one fourth of total deaths caused by contaminated diseases, 95% of deaths without vaccination in time. When was bitten by mad dog or having large, deep and dangerous wound that near the nervous centre, the surface of genitourinary... there must be used right away antiserum besides vaccine. Subjects are more likely infected with mad virus who need to vaccinate before
Rabies ; Vaccination ; humans ; animals ; viruses

Background Nha Trang Institute of Vaccines Medical Biologicals has produced successfully vaccine for human influenza A/H5N1 in embryonic chicken eggs. Effectiveness of the vaccine immune response is highly dependent on the type of adjuvant used.\r\n', u'Objective: To study adjuvants for preparing A/H5N1 influenza vaccine.\r\n', u'Subjects and methods: The study used a comparative approach on capacity to increase the immune response of various adjuvants AIPO4, Chitosan and Freund tested in mice. Experiment of erythrocyte agglutination reaction is used to measure levels of antibody response in mice blood. The process of weight gain in mice after injection of vaccine adjuvant mixture is monitored.\r\n', u'Results: HA antibody level of the vaccine adjuvant mixture is higher than of the vaccine without adjuvant. Capacity of stimulating immune response of Chitosan adjuvant is higher than AlPO4. Repeat injection on day 20th is suitable for vaccine with AlPO4or vaccine without adjuvant. Repeat injection is after day 20th for vaccine with Chitosan or Freund depending on the amount of residual antibody in the blood. \r\n', u'Capacity of stimulating immune response of Freund adjuvant is the best in the 3 adjuvants but the safety of this adjuvant is low\r\n', u' Freund adjuvant should be used only for animals. When using Freund adjuvant to induce immunity to animals it should determine the amount of antibodies causing immune before repeating.\r\n', u'Conclusion: Freund adjuvant should be used only for animals. \r\n', u'\r\n', u'
Influenza A Virus ; H5N1 Subtype