We report here a surgical case of sinus of Valsalva and right atrium fistula associated with acute infective endocarditis (AIE) without perivalvular abscess cavity or aneurysm of the sinus of Valsalva (ASV). A 51-year-old man, who had been given a diagnosis of rheumatic aortic stenosis and regurgitation (AsR) and mitral stenosis and regurgitation (MsR) and tricuspid regurgitation (TR) by echocardiography, had a high fever 2 months after removal of teeth and AIE was diagnosed. He was referred to our hospital because sinus of Valsalva and right atrium fistula were detected by echocardiography and congestive heart failure (CHF) deteriorated during medical treatment. Perivalvular abscess cavity and ASV were not detected by preoperative echocardiography. Medical treatment was continued after admission, and operation was done after amelioration of the CHF and infection were recognized. The aortic valve was removed together with vegetation, two areas of the aortic wall in which the tissue was fragile were cauterized by electrocautery, patch closure at the sinus of Valsalva was performed using a partial of e-PTFE graft and aortic valve replacement (AVR) and mitral valve replacement (MVR) were done. Though residual aortic-right atrium shunt was detected after the operation, the postoperative course was good with no CHF or signs of infection.

AIMThe redox dynamics of the rat liver in the whole body hyperthermia was measured by the decay rate of the ESR spectra used carbamoyl-PROXYL as a spin probe.

METHODSFifty-two Wistar male rats were randomly assigned to four groups and each group was subjected to only one of the following treatments: heat stress (HS group), anesthesia without hyperthermia (control group), pretreatment with MPG (MPG + HS group) and pretreatment with saline (No-MPG group). The solution of carbamoyl PROXYL was added to rat liver homogenate from 0, 1, 2, 6 and 24 h after heating at concentration of 0.1 mmol/L. sequentially the ESR spectra of the samples were immediately recorded by X-band ESR spectrometer.

RESULTSCompared with the control group, the signal decay rate was increased gradually after heat treatment, and attained the maximum at 2 h, and then returned to the normal level at 24 h. This signal intensity effect was reduced by MPG pretreatment.

CONCLUSIONGeneration of reactive oxygen species in liver may be induced by heat stress.

Animals ; Electron Spin Resonance Spectroscopy ; methods ; Heat-Shock Response ; Hot Temperature ; Liver ; physiopathology ; Male ; Oxidation-Reduction ; Oxidative Stress ; Rats ; Rats, Wistar