4.Human Individual Variability and Clinical Medicine. Masuyama's rule and its usefulness.
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 1997;60(3):175-189
Prof. Motosaburo Masuyama has detailedly investigated the statistical distribution of more than 300 kinds of human biological traits, such as biochemical substances in blood. In his study, he found several empirical laws with respect to CV (coefficient of variation) of these traits, and proposed the two rules of human individual variability. The one was CV of fundamental blood components were less than 0.3, and another was the CV of these components did not differ by sex, race and age. In this paper, we first introduced his study. Second, we discussed the usefulness of his rules in the determination of initial dosis for patients with allergy. In addition, we tested the validity of his rules by using large size data obtained by the country-wide health check. We concluded that Masuyama's rules could apply many types of normal blood components of human being and be useful for designingg drug therapy, and for arranging clinical data. Since precise investigation performed by us showed that there are definite difference of CV between male and female, young and old, in many blood components, further study is needed.
5.The Study on the Difficulty of the Tests of Gait Disturbance.
Kazuhiko SHIMIZU ; Hideo MIYAHARA
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 1998;61(2):106-114
In 61 patients with hemiplegia who were under a rehabilitation program, the grade of gait disturbance of each patient was examined by 6 physical therapists. The examination consisted of observation on 46 kinds of gait or related actions; of which 14 were with a handrail, 16 with a cane and 16 with empty hands. Each rater was requested to rate the patient's performance on the basis of 4 stages: impossible, possible with human assistance, possible but not practical, and practical from the standpoint of ADL (activities of daily living). We assigned 1 to the former two cases, whereas 0 to the latter two, respectively.
The data collected in this way were analysed by making the cross-table and counting the number of possible tests in each patient and that of possible patients in each test, respectively. By using these results, we rearranged the order of both cases and tests. We found that the rank of this new arrangement of the tests roughly paralleled to that of the difficulty of the tests and could be diverted to be utilized for the scaling of the latter.