The purpose of this research was to develop a reflection program to support the practice of end-of-life care for nurses and to examine its effectiveness and feasibility. We developed and examined the effectiveness of a facilitator-based reflection program (FRP) and card-based reflection program (CRP). Average scores for both the FRP and CRP were measured using a Knowledge, Attitude and Difficulty Scale for palliative care and Self-education Ability Scale implemented before, immediately after, and 3 months after the program. The changes in scores were compared. This research was conducted with approval from the ethics review committee. Nine people participated in the FRP, and 15 in the CRP. FRP significantly reduced difficulty concerning palliative care compared to CRP. FRP significantly increased knowledge compared to CRP. Similar results were obtained within the FRP group. Both FRP and CRP were considered highly feasible because the program evaluation was high. In the future, it is necessary to clarify the effect of the reflection program by reviewing the research design.