1.Inhibition by Ginseng of Colon Carcinogenesis in Rats.
Shoji FUKUSHIMA ; Hideki WANIBUCHI ; Wei LI
Journal of Korean Medical Science 2001;16(Suppl):S75-S80
The inhibitory effects of ginseng on the development of 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) in the colon were investigated in rats. Male, 6-week-old rats were injected with DMH once a week for 4 weeks. Rats in Groups 1 and 2 were fed diets containing red and white ginseng, rerspectively, at a dose of 1% for 5 weeks, starting one week before the first treatment of DMH. Animals in Groups 3 and 4 received red or white ginseng for 8 weeks starting after DMH treatment. Group 5 served as a carcinogen control group. Numbers of ACF with at least four crypts were significantly reduced in the colon of Group 2 treated with red ginseng combined with DMH. Moreover, rats were injected with DMH 4 times at one-week intervals. They were also fed diets containing 1% red or white ginseng or the control diet throughout 30 days of the experiment. Treatment with red ginseng resulted in a significant decrease of 5- bromo-2'-deoxyuridine labeling indices in colonic crypts comprising ACF. These findings suggest that dietary administration of red ginseng in combination with DMH suppresses colon carcinogenesis in rats, and the inhibition may be associated, in part, with inhibition of cell proliferation, acting on ACF in the colonic mucosa.
1,2-Dimethylhydrazine/adverse effects
;
Animal
;
Anticarcinogenic Agents/*pharmacology
;
Carcinogenicity Tests
;
Carcinogens/adverse effects
;
Colonic Neoplasms/pathology/*prevention & control
;
Male
;
*Panax
;
Plant Roots
;
Precancerous Conditions/pathology/*prevention & control
;
Rats
;
Rats, Inbred F344
2.Endoscopic ultrasound-guided drainage of postoperative pancreatic fluid collections
Shigeru NISHIYAMA ; Takeshi HISA ; Aki EGO ; Shogo SAKATA ; Yui ITO ; Akiharu KUDO ; Takahiro YAMADA ; Shozo OSERA ; Hideki FUKUSHIMA ; Shunta ISHIZAKI ; Ryoga HAMURA ; Masashi TSUNEMATSU ; Kyohei ABE ; Yoshihiro SHIRAI ; Shinji ONDA
International Journal of Gastrointestinal Intervention 2025;14(1):15-19
Background:
Endoscopic ultrasound-guided drainage (EUSD) is an effective treatment for postoperative pancreatic fluid collections (POPFCs); however, standards regarding stents used for EUSD have not been established. This study analyzed the outcomes of EUSD of POPFCs at our hospital and examined the safety and effectiveness of plastic stents/tubes.
Methods:
This retrospective, single-center study focused on EUSD of POPFCs performed at our hospital. We examined the rates of technical success, clinical success, adverse events, and recurrence.
Results:
Twenty-seven patients were included in this study. The initial drainage methods comprised one nasocystic plastic tube (NPT) and one double-pigtail plastic stent (DPS) for 19 (70.4%) patients, two DPS for four (14.8%) patients, one NPT for three (11.1%) patients, and one lumen-apposing metal stent for one (3.7%) patient. The technical success and clinical success rates were both 100%. Fourteen of the 19 patients with one NPT and one DPS improved, but five patients required additional interventions and improved with fistula site dilation. Although recurrence occurred in one patient, improvement was achieved with second EUSD. Early adverse events comprised one case of bleeding for which hemostasis was achieved by performing coil embolization. Late adverse events comprised three cases of DPS migration; however, no additional intervention was required.
Conclusion
The use of plastic tubes/stents is safe and effective for EUSD of POPFCs.
3.Endoscopic ultrasound-guided drainage of postoperative pancreatic fluid collections
Shigeru NISHIYAMA ; Takeshi HISA ; Aki EGO ; Shogo SAKATA ; Yui ITO ; Akiharu KUDO ; Takahiro YAMADA ; Shozo OSERA ; Hideki FUKUSHIMA ; Shunta ISHIZAKI ; Ryoga HAMURA ; Masashi TSUNEMATSU ; Kyohei ABE ; Yoshihiro SHIRAI ; Shinji ONDA
International Journal of Gastrointestinal Intervention 2025;14(1):15-19
Background:
Endoscopic ultrasound-guided drainage (EUSD) is an effective treatment for postoperative pancreatic fluid collections (POPFCs); however, standards regarding stents used for EUSD have not been established. This study analyzed the outcomes of EUSD of POPFCs at our hospital and examined the safety and effectiveness of plastic stents/tubes.
Methods:
This retrospective, single-center study focused on EUSD of POPFCs performed at our hospital. We examined the rates of technical success, clinical success, adverse events, and recurrence.
Results:
Twenty-seven patients were included in this study. The initial drainage methods comprised one nasocystic plastic tube (NPT) and one double-pigtail plastic stent (DPS) for 19 (70.4%) patients, two DPS for four (14.8%) patients, one NPT for three (11.1%) patients, and one lumen-apposing metal stent for one (3.7%) patient. The technical success and clinical success rates were both 100%. Fourteen of the 19 patients with one NPT and one DPS improved, but five patients required additional interventions and improved with fistula site dilation. Although recurrence occurred in one patient, improvement was achieved with second EUSD. Early adverse events comprised one case of bleeding for which hemostasis was achieved by performing coil embolization. Late adverse events comprised three cases of DPS migration; however, no additional intervention was required.
Conclusion
The use of plastic tubes/stents is safe and effective for EUSD of POPFCs.
4.Endoscopic ultrasound-guided drainage of postoperative pancreatic fluid collections
Shigeru NISHIYAMA ; Takeshi HISA ; Aki EGO ; Shogo SAKATA ; Yui ITO ; Akiharu KUDO ; Takahiro YAMADA ; Shozo OSERA ; Hideki FUKUSHIMA ; Shunta ISHIZAKI ; Ryoga HAMURA ; Masashi TSUNEMATSU ; Kyohei ABE ; Yoshihiro SHIRAI ; Shinji ONDA
International Journal of Gastrointestinal Intervention 2025;14(1):15-19
Background:
Endoscopic ultrasound-guided drainage (EUSD) is an effective treatment for postoperative pancreatic fluid collections (POPFCs); however, standards regarding stents used for EUSD have not been established. This study analyzed the outcomes of EUSD of POPFCs at our hospital and examined the safety and effectiveness of plastic stents/tubes.
Methods:
This retrospective, single-center study focused on EUSD of POPFCs performed at our hospital. We examined the rates of technical success, clinical success, adverse events, and recurrence.
Results:
Twenty-seven patients were included in this study. The initial drainage methods comprised one nasocystic plastic tube (NPT) and one double-pigtail plastic stent (DPS) for 19 (70.4%) patients, two DPS for four (14.8%) patients, one NPT for three (11.1%) patients, and one lumen-apposing metal stent for one (3.7%) patient. The technical success and clinical success rates were both 100%. Fourteen of the 19 patients with one NPT and one DPS improved, but five patients required additional interventions and improved with fistula site dilation. Although recurrence occurred in one patient, improvement was achieved with second EUSD. Early adverse events comprised one case of bleeding for which hemostasis was achieved by performing coil embolization. Late adverse events comprised three cases of DPS migration; however, no additional intervention was required.
Conclusion
The use of plastic tubes/stents is safe and effective for EUSD of POPFCs.
5.Solution Proposal for 5 Challenges to be Resolved in Formalizing the Logical Format of Kampo-Based Diagnosis by Building Consensus Among 6 Medical Institutions Specialized in Kampo Herbal Medicine
Hiroshi ODAGUCHI ; Tatsuya ISHIGE ; Yuichi ITO ; Akino WAKASUGI ; Mariko SEKINE ; Toshihiko HANAWA ; Takao NAMIKI ; Shinichi MURAMATSU ; Makoto ARAI ; Tadamichi MITSUMA ; Yutaka SHIMADA ; Naotoshi SHIBAHARA ; Hideki ORIGASA
Kampo Medicine 2020;71(3):284-295
We are planning a study focused on the gathering of clinical data for the purpose of formalizing diagnostic logic at 6 institutions specialized in Kampo-based medical examinations. However, during the planning stage, it has been recognized that there are a large number of Kampo formulas to be studied, and differences among faculties and individuals exist regarding how to identify each Kampo formula, methods of gathering findings, and the evaluation of efficacy. Here we report the solution proposal reached after building consensus among all participating faculties on these issues. After raising the issues, conferences were held for each of them, until a unanimous consensus was obtained. As a result, the following conclusions were reached. Thirty-three Kampo formulas were selected as targets for the formalization of diagnostic logic. In addition, the range of dosage forms, crude drug ingredients, and permissible dosages for each Kampo formula were determined. Regarding clinical findings for these Kampo medicines, the items to be collected and evaluation criteria were also established. The criteria for evaluating the validity and safety of each Kampo medicine were decided, together with the grading and timing of evaluation. We hope that our solution proposal reached after building consensus becomes the basis for Kampo research in the future.