1.Study on Anti-Proliferative Activities of Cultured Cordyceps Militaris on Cancer Cells
Msayuki HIGASHINO ; Hiroshi HORIE ; Masakatu ITO ; Keiko TANAKA ; Yasuki FUKUDA ; Shozo NISHIDA ; Kazuya MURATA ; Hideaki MATSUDA
Japanese Journal of Complementary and Alternative Medicine 2013;10(1):51-57
Cordyceps militaris has been known to produce an anticancer agent, cordycepin. Investigation on optimum culture condition for C. militaris had been performed. In the research program for discovering a novel function in the culture of C. militaris, the culture media was applied to a proliferation assays using various cell lines. The media showed significant anti-proliferative activities against al cell lines, especially to human leukemia cell line HL-60. The activity-guided purification of active ingredient was performed to obtain uracil. To the best of our knowledge, uracil has not been reported to possess anti-proliferative activity. However, the uracil obtained from the culture media was subjected to ICP-MS analysis to reveal that sodium, potassium and magnesium were found to co-exist with uracil, which might show anti-proliferative activity. Further study on the mechanism of the expression of the activity is now underway.
2.Daily activity relates to not only femoral bone mineral density, but also hip structural analysis parameters: A cross-sectional observational study
Norifumi FUJII ; Nobukazu OKIMOTO ; Manabu TSUKAMOTO ; Norimitsu FUJII ; Kei ASANO ; Yoshiaki IKEJIRI ; Toru YOSHIOKA ; Takafumi TAJIMA ; Yoshiaki YAMANAKA ; Yukichi ZENKE ; Makoto KAWASAKI ; Junya OZAWA ; Takuya UMEHARA ; Shogo TAKANO ; Hideaki MURATA ; Nobuhiro KITO
Osteoporosis and Sarcopenia 2021;7(4):127-133
Objectives:
Physical activity to maintain bone mass and strength is important for hip fracture prevention. We aim to investigate the relationship between physical performance/activity status and bone mineral density (BMD)/hip structural analysis (HSA) parameters among postmenopausal women in Japan.
Methods:
Sixty-two postmenopausal women diagnosed with osteoporosis (mean age: 72.61 ± 7.43 years) were enrolled in this cross-sectional observational study. They were evaluated for BMD and HSA in the proximal femur by dual-energy X-ray absorptiometry and underwent several physical performance tests, the Geriatric Locomotive Function Scale of 25 questions (GLFS-25). Principal component analysis (PCA) was used to summarize data on the BMD/HSA parameters. Partial correlation analysis, multiple regression analysis, and structural equation modeling (SEM) were performed to investigate the relationship between physical performance/activity status and BMD/HSA parameters of the proximal femur.
Results:
In a partial correlation analysis adjusted for age and body mass index (BMI), GLFS-25 scores were correlated with HSA parameter (|r| = 0.260–0.396, P < 0.05). Principal component 1 (PC1) calculated by PCA was interpreted as more reflective of bone strength based on the value of BMD/HSA parameters. The SEM results showed that the model created by the 3 questions (Q13, brisk walking; Q15, keep walking without rest; Q20, load-bearing tasks and housework) of the GLFS-25 had the best fit and was associated with the PC1 score (β = −0.444, P = 0.001).
Conclusions
The GLFS-25 score was associated with the BMD/HSA parameter, which may reflect the bone strength of the proximal femur as calculated by PCA.