We investigated tte effects of Bukuryoshigyaku-to on cxperimental hemorrhagic shock. Twelve mongrel dogs, which were anesthetized with 26mg/kg of pentobarbital were used, Bukuryoshigyaku-to was given to six dogs and saline solution alone was given to six dogs as a control. Under artificial respiration management, a hemorrhagic shock model was created by modified Wiggers method. The drug was administered by enema immediately after the compensatory phase. Bukuryoshigyaku-to, consistied of 4g Bukuryo (Hoelen), 2g of Kanzo (Glycyrrhizae Radix), 2g Kankyo (Zingiberis Siccatum Rhizoma), 2g of Ninjin (Ginseng Radix) and 2g of Bushi (Aconiti Tuber), which were extracted by boiling for approximately 30 minutes.
The results showed no statistical differences in the changes in the mean arterial pressure and central venous pressure between the two groups. However, the cardiac index was significantly higher in the observation phase in the Bukuryoshigyaku-to group than in the control group. A drop in body pressure was prevented in the traditional Bukuryoshigyaku-to group.
These findings suggest the effectiveness of Bukuryoshigyaku-to in the treatment of hemorrhagic shock.

The present aging rate in Japan of some 28% will continue to increase along with the advancing age of elderly persons. Therefore, the demand for care will also increase. Approximately 25% of the need for nursing-care defined by the Japanese long-term care insurance system is associated with disorders or deterioration of locomotive organs. Therefore, the prevention and treatment of diseases in the locomotor system and maintenance of motor function are important for extended healthy life span and to decrease the demand for long-term care. Based on this background, the Japanese Orthopaedic Association (JOA) proposed the concept of locomotive syndrome (LS) in 2007, which is defined as reduced mobility due to impaired locomotive organs. Changes in locomotion must be noticed early to ensure the timely implementation of appropriate checks and measures of locomotion can uncover risk of acquiring LS. The acquisition of an exercise habit, appropriate nutrition, being active and evaluating and treating locomotion-related diseases are important to delay or avoid LS. The JOA recommends locomotion training consisting of four exercises to prevent and improve LS. Countermeasures against LS should become a meaningful precedent not only for Japan, but for other countries with rapidly aging populations.
Aged ; Aging ; Asian Continental Ancestry Group ; Exercise ; Humans ; Insurance, Long-Term Care ; Japan ; Locomotion ; Long-Term Care