No abstract available.
Pulmonary Disease, Chronic Obstructive* ; Pulmonary Heart Disease* ; Tuberculosis, Pulmonary*

Antihypertensive and untoward effects of atenolol were studied in 20 cases of essential hypertension with their average pre-treatment systolic and diastolic blood pressures of approximately 160mmhg and 100mmhg, respectively. All patients were assigned to a single dose of 50mg atenolol once daily for a period of four weeks, and a weekly complete history and physical examination. Besides routine blood counts and urinalysis, blood chemistry relating to hepatic and renal functions, and electrolytes balance as well as fasting blood sugar levels were checked before and at the end of medication. In addition, in 10 cases, pulmonary function was studied before and after one week of treatment. With the therapy, the diastolic blood pressure fell to 90mmHg or below in 17 out of 20 cases(85%), and the pre-treatment diastolic blood pressure in the remaining three cases who responded poorly was 108mmHg or above. However two cases of the 17, who responded well and whose blood pressure became normal, had an initial diastolic pressure of 110mmHg each. The hypotensive effect of atenolol on both systolic and diastolic blood pressures was essentially similar, and the effect appeared during the first week with its peak effect occurring during the third week. There was no significant difference during treatment between recumbent and sitting blood pressures, both systolic and diastolic; thus no postural hypotension was observed. The comparison of the results of post-treatment laboratory tests with pre-treatment data revealed no significant changes. These suggest that atenolol can be used in patients with diabetes mellitus, chronic obstructive pulmonary disease or cerebral sclerosis, which are frquently associated with essential hypertension. Also a once-daily dose with satisfactory hypotensive response is one of very practical advantages of atenolol, particularly from the patient's point of view, in the treatment of hypertension, in which a life-long therapy is needed in most cases. Thus atenolol seems to be one of the most attractive choices of drugs for the treatment of mild to moderate hypertension.
Atenolol* ; Blood Glucose ; Blood Pressure ; Chemistry ; Diabetes Mellitus ; Electrolytes ; Fasting ; Humans ; Hypertension* ; Hypotension, Orthostatic ; Physical Examination ; Pulmonary Disease, Chronic Obstructive ; Tuberous Sclerosis ; Urinalysis

For the non-invasive evaluation of cardiac performance in hyperthyroidism, fractional systolic and diastolic time intervals were determined in 96 female patients with hyperthyroidism from the mechanocardiograms which included apexcardiograms together with electrocardiograms, phonocardiograms and carotid arterial pulse tracings. The observed values of the time intervals inversely related to heart rate, i.e., ejection period, mechanical systole, isovolumic relaxation time and active ventricular filling period, were significantly shortened in proportion to the severity of the disease in general, as determined by the rate of the radioactive iodine uptake of the thyroid glands. However, these values were not significantly different from those of the predicted for heart rate, except for one of mechanical systoles which is a time interval from the onset of the systolic upstroke in the apexcardiogram to the second aortic sound. This suggests that the shortening of these observed values is promarily due to tachycardia associated with hyperthyroidism. One the other hand, the observed values of the time intervals unrelated to heart rate, i.e., electromechanical delay, isovolumic contraction time together with one of its components, namely ventricular pressure elevation time, and rapid ventricular filling period, were significantly shorter than those in the controls, although the degree of the shortening was not related to the degree of the radioactive iodine uptake of the thyroid gland. It appears that the shortening of these time intervals is related to the altered cardiac function caused by hyperthyroidism and, in particular, that of the isovolumic contraction time and ventricular pressure elevation time reflects enhancemet by the thyrotoxic myocardial contractility.
Electrocardiography ; Female ; Hand ; Heart Rate ; Humans ; Hyperthyroidism* ; Iodine ; Relaxation ; Systole ; Tachycardia ; Thyroid Gland ; Ventricular Pressure

The pulse transmission times measured from polygraphic recordings of cardiac events were studied in 52 cases of female hyperthyroidism and 60 cases of normal females. The pulse transmission times measured in this study were M1-S, R-S and C-S intervals, i.e., the time intervals from the mitral first sound, the R wave of an electrocardiogram and the onset of the upstroke of the ventricular contraction in an apexcariogram to the finger tip, respectively, and the A2-C interval, and interval from the aortic second sound to the finer tip. The M1-S, R-S and C-S intervals, which were measured during systole, were significantly shortened in proportion to the severity of the disease, whereas the A2-C interval, which was a measurement during diastole, was well within normal limits. By correcting these observed values for the heart rate, the A2-C interval became significantly longer than in the control, apparently in proportion ot the severity of the disease. The M1-S, R-S and C-S intervals, however, were normalized by the correction. In the analysis of the correlation of these observed values to the age and the various hemodynamic parameters, it was noted that the A2-C interval was negatively correlated to the diastolic and mean blood pressure, which tended to be low in this condition, and was positively correlated to the age, but had no correlation to the heart rate or the systolic blood pressure. The A2-C interval also showed positive and negative correlation to left ventricular ejection time/isovolumic contraction time ratio and preejection period/left ventricular ejection time ratio, respectively. On the contrary, there was a tendency for the remaining intervals measured during systolic to be negatively correlated to the systolic blood pressure, which tended to be high, heart rate and age, as well as systolic time intervals. These facts suggested that the shortening of the M1-S, R-S and C-S intervals was caused primarily by the rapid heart rate and also by the systolic hypertension. It was strongly felt that the A2-C interval was of a limited value as an index of the pulse transmission in hyperthyroidism.
Blood Pressure ; Diastole ; Electrocardiography ; Female ; Fingers ; Heart Rate ; Hemodynamics ; Humans ; Hypertension ; Hyperthyroidism* ; Systole

Hepatic blood flow was studied by the determination of the fractional clearance of intravenously administered colloid 198Au in 35 cases of normal subjects, 36 cases of liver cirrhosis, 18 cases of primary cancer of the liver, seven cases of liver abscess, five cases of hepatitis and 10 cases of hepato-biliary diseases. There was no appreciable difference in the mean values of the fractional clerance between the normal subjects and biliary tract diseases. On the contrary, it was diminshed in liver cirrrhosis, primary cancer of the liver, hepatitis and liver abscess compared with that in the normal subjects, and the diminution in liver cirrhosis and primary cancer of the liver was significant, and also the fractional clearance in the former was significant, and also the fractional clearance in the former was significantly smaller than that in the latter. However, the individual datum both in the normal control and diseased groups showed a marked overlapping among them except that in the normal subjects and biliary tract diseases the fractional clearance was above 0.10 in almost all cases. In cirrhosis of the liver there was no relationship between the fractional clearance and liver functions.
Biliary Tract Diseases ; Colloids ; Fibrosis ; Hepatitis ; Liver ; Liver Abscess ; Liver Cirrhosis ; Liver Neoplasms

As a part of fundamental studies for establishing appropriate electrocardiographic criteria of left ventricular hypertrophy for Koreans, 39 various criteria proposed by 25 authors were applied to 500 Koreans and the reliability of each criterion was analysed based upon cardiothoracic ratios in the chest teleroentgenograms. The subjects analysed in this study included cardiac and non-cardiac patients as well as healthy adults: in all of them electrocardiograms and chest roentgenograms were obtained on the same day. Both true and false positivities of the precordial voltage criteria were extremely high, whereas those of voltage criteria of the extremity leads and the remainder of various criteia were qutie low except for the point score system of Romhilt and Estes, which revealed relatively high true positivity and low false positivity. True positivities of all precordial voltage criteria were higher in males than in females. Their false positivities were also higher in males, except for criteria SV1>==24mm, RV1<==1mm and RV6>RV5, which were higher in females. No significant differences were noted between males and females, however, in the true and false positivities in the voltage criteria of the extremity leads. True and false positivities of the other criteria excluding various voltage criteria were also slightly higher in males than in females. In females, true positivities of the precordial voltage criteria were not closely related to the cardiothoracic ratios, whereas those of voltage criteria of the extremity leads and of the other criteria excluding voltage criteria were higher in those with greater cardiothoracic ratios. In males, however, true positivities of nearly all the criteria, including precordial voltage criteria, were higher in those with increased cardiothoracic ratios. In both males and females, criteria SV1>==24mm, RV1<==1mm, RV5>==33mm, RV6>RV5, RV6>==26mm, ventricular activation time(VAT) and left axis deviation(LAD) revealed low true and false positivities indicating that these criteria were of little practical values. In females, true positivitieies of criteria RaVF>==20mm or 21mm and VAT in V(5-6)>==0.66sec. were zero, indicating that these criteria were totally impractical. Both true and false positivities of almost all precordial voltage criteria were higher in Koreans than in Westerns but those of the voltage criteria of the extremity leads were similar in both groups. The remainder of the criteria revealed lower true positivities in Koreans than in Westerns but false positivities were similar in both groups. These facts denote that higher false positivities of electrocardiographic criteria of left ventricular hypertrophy proposed by the western authorities, when applied to Koreans, are mainly due to the precordial voltage criteria. Criteria with a high true positivity and low false positivity indicating., more reliable and more appropriate for Korean males, were RV6>20mm, RV(5-6)>==27mm and SV2+RV(5-6)>45mm in the precordial leads, RaVL>==7.6mm in the extremity leads and point score system. In females, they were similar to those in males except that criterion SV1+RV(5-6)>35mm was more appropriate than SV2+RV(5-6)>45mm. However, these selected criteria also revealed higher false positivities in Koreans than in Westerns, and obviously still further studies are needed to establish more reliable criteria for Koreans.
Adult ; Male ; Female ; Humans

Hemodynamic effects of acute carbon monoxide poisoning were studied in mongrel dogs. In this study dogs were divided into two groups, namely the control and the experimental. Carbon monoxide poisoning in the experimental group was induced by the breathing of about 2% CO gas mixture for 15 minutes, and this group was further divided into two, in which the arterial CO saturation was below 50%, 30 minutes after the CO gas breathing for 15 minutes (group I) and above 50% (group II). The heart rate was markedly decreased in the both experimental groups, particularly in the group I. The cardiac index showed a relative increase in the group II compared to that of the control, and the stroke volume also showed a relative increase in the both experimental groups, being more marked in the group II. Thus the increase in the cardiac output in the group II was caused mainly by the increase in the stroke volume. The femoral artery mean pressure was decreased both in the control and the experimental groups, being more marked in the group II. There was no appreciable difference in the femoral venous pressure between the control and the experimental groups. The total peripheral resistance was decreased 30 minutes after CO gas breathing in both experimental groups, particularly in the Group II. The pulmonary artery mean pressure showed a decrease in the control and the experimental groups, and there was no prarticular difference between these two groups. The changes in the total pulmonary resistance were rather similar to those of the total peripheral resistance.
Animals ; Carbon Monoxide Poisoning* ; Carbon Monoxide* ; Carbon* ; Cardiac Output ; Dogs ; Femoral Artery ; Heart Rate ; Hemodynamics* ; Pulmonary Artery ; Respiration ; Stroke Volume ; Vascular Resistance ; Venous Pressure

A study was made of the respiratory effects of acute carbon monoxide poisoning in mongrel dogs. In this study the dogs were divided into two groups, namely the control and the experimental. In the experimental group, carbon monoxide poisoning was induced by the rebreathing of about 2% carbon monoxide gas mixture for 15 minutes, and the respiratory functions in this group were compared to those in the control group. A significant increase in the minute ventilation was noted in both the control and the experimental groups, and in the latter there was an increase in the respiratory rate and a decrease in the tidal volume compared to those in the control group. In both groups, oxygen consumption showed no significant change and there was a fall in the arterial carbon dioxide tension, but the carbon dioxide elimination was slightly lower in the experimental group.
Animals ; Carbon Dioxide ; Carbon Monoxide Poisoning* ; Carbon Monoxide* ; Carbon* ; Dogs ; Oxygen Consumption ; Respiratory Rate ; Tidal Volume ; Ventilation

Differences in systolic time intervals(STI's) attributable to the types of mechanocardiographs used for their determinations were studied in a total of 341 healthy adult males. The STI's were measured from mechanocardiograms consisting of simultaneously rocorded electrocardiograms, phonocardiograms and carotid arterial pulse tracings obtained by each of three different types of mechanocardiographs in 125, 56 and 160 subjects, respectively. The study revealed that there were slight to considerabe differences among the three groups in the correlation coefficients between the individual STI's and heart rate. Thus, regression equations using heart rate as variables, for those STI's which were significantly correlated with heart rate, differed slightly to considerably among these groups. In addition, the mean values of those STI's and their derivatives, which showed no significant correlation with heart rate, were also silghtly or significantly different among the three groups. These findings suggest that if STI's obtained from patients are to be adequately evaluated at all, each laboratory must define its own normal standards worked out by using its own methods of recording and analysis of the mechanocardiogram, and cannot rely on those proposed by others.
Adult ; Electrocardiography ; Heart Rate ; Humans ; Male ; Systole*

Lung Volumes and alveolorespiratory function were studied in 30 cases of pure or predominat mitral stenosis in slightly to moderately compromized state, and the results were compared with those in the normal controls. In patients with mitral stenosis, there was a singnificant reduction in the vital capcity and the total lung capacity, whereas the residual volume and its ratio to the total lung capacity were significantly increased. The distribution of inspired gas was uneven as reflected by increase in the lung clearnace index and in the slope of phase III of the single breath nitrogen washout curve. The alvelolar arterial oxygen tension gradient and the physiological dead space were singinificantly increased despite a singinificant decrease in the arterial carbon dioxide tension. The diffusing capacity was also reduced in some cases.
Carbon Dioxide ; Humans ; Lung* ; Mitral Valve Stenosis* ; Nitrogen ; Oxygen ; Residual Volume ; Total Lung Capacity