In this study, effects of the intraventricular and intravenous dimethylphenylpiperazinium (DMPP) on the renal function of rabbits were investigated. Intraventricular DMPP (100 microgram) elicited diuresis following antidiuresis concomitant with the changes in renal blood flow, glomerular filtration rate and urinary excretory amount of electrolytes (Na and K). The changes in urine flow correlated with the changes in renal blood flow, glomerular filtration rate and excretory rates of electrolytes in urine. Intravenous DMPP (50 microgram/kg) did not affect the renal function.
Dimethylphenylpiperazinium Iodide ; Diuresis ; Electrolytes ; Glomerular Filtration Rate ; Rabbits* ; Renal Circulation

No abstract available.
Growth Hormone* ; Testosterone*

PURPOSE: This study aimed to investigate the factors of occurrence of amenorrhea and the severity of climacteric symptoms in breast cancer patients who underwent chemotherapy. METHOD: Women diagnosed with breast cancer without metastasis or recurrence, had surgery followed by chemotherapy, and had menses at the time of surgery were recruited from S hospital located in Seoul. A total of 99 women aged 31 thru 55 years participated and filled out a structured questionnaire including the Functional Assessment Cancer Therapy-Breast plus Endocrine Symptom when they visited the clinic for follow-up. RESULT: In 88 women amenorrhea occurred within an average of 2 months since beginning chemotherapy, and menstruation was resumed in only 11 women. About 98% of women aged over 40 experienced a cessation in menses thus age was an apparent factor of amenorrhea (Exp(B)=.76, p<.05). Presence of chronic disease (beta=.25, p<.05) and body weight change (beta=.30, p<.01) were significant factors influencing the severity of climacteric symptoms. CONCLUSION: Nurses need to have clinical evidences of menstrual changes due to breast cancer treatment. Information about premature menopause and climacteric symptoms should be provided according to women's health conditions so that they cope better during their survival.
Aged ; Amenorrhea ; Body Weight Changes ; Breast ; Breast Neoplasms ; Chronic Disease ; Climacteric ; Female ; Humans ; Menopause, Premature ; Menstruation ; Neoplasm Metastasis ; Phosphatidylethanolamines ; Surveys and Questionnaires ; Recurrence ; Women's Health

In the case of IIc type of early gastric cancer occuring from the area of ulcer sear, endoscopic differentiation between it and beoign ulcer scar is occasionally very difficult, due to the absence of characteristic malignant features. The presence of the irregular granular mucosal changes on the area of ulcer scar may be very helpful in the differential diagnosis between early gastric cancer and benign ulcer sear. And underetanding of the malignant cycle of early gaetric cancer is very important for the diagnosis of the depressed forms of early gastric cancer, We experienced and report a cases of IIc type of early gastric cancer diagnosed before operation by the endoscopic finding of irregular granular mucoeal changes on the area of ulcer scar and showing part of malignant cycle.
Cicatrix* ; Diagnosis ; Diagnosis, Differential ; Stomach Neoplasms* ; Ulcer*

Diseases of the thyroid gland are manifested by either increase in gland size, alterations in hormonal secretion, or both. Changes in gland size and weight are associated with toxic or nontoxic goiter, adenomas, thyroiditis, or malignancies. Many reports can be found to study thyroid disease, but there is no report of thyroid disease in childhood. So the present studies have surveyed the record of patient with thyroid disorders seen at Severance h spital from 1969 to 1979. The following results were obtained. 1. Among 76 cases, 56 cases were fmeale and theoratio of male and female thyroid disease was 1:3.5. 2. In classification of thyroid diseases according to function, hyperthyroidism was 20 cases(26.3%), euthyroidism 38 cases(50%), and hypothyroidism 18 cases(23.7%). 3. Disease distribution according to age, congenital hypothyroidim comprises about 75% of thyroid disease below 10 year old, and adenoma 42%, hyperthyoidism 27% of thyroid disease from 10 to 18 years old. 4. The most common sign and symptom was goiter(75%) in hyperthyroidim, palpable mass(100%) in euthyroidism, distended abdomen(83.3%) in hypothyroidism. 5. Treatment of thyoid disease was medical treatment(44 cases), surgical treatment(23 cases), and observation(9 cases).
Adenoma ; Adolescent ; Child ; Classification ; Female ; Goiter ; Humans ; Hyperthyroidism ; Hypothyroidism ; Male ; Thyroid Diseases* ; Thyroid Gland* ; Thyroiditis

CT findings and comparison between clinical and CT staging were reviewed in 45 consecutive patients withbiopsy proven carcinoma of the cervix. CT was done for staging of primary untreted cercial cancer in 36 patientsand for diagnosis of recurrent cervical cancer or follow-up study 14 times in 9 patients . The results are asfollows; 1. As comparing with clinical staging in 36 cases, CT agreed with clinical stage in 19 cases (52.8%),upstaged in 10 cases(27.8%) and downstaged inn 7 cases (19.4%). 2. The main upstaged CT findings are detection ofunsuspected bladder or rectal invasion and paraaortic lymph node metastasis. Inadequate delineation ofintravaginal tumor was the leading causes of understage of CT than clinical one. 3. CT detected all 10 cases ofthe hydronephrosis shown by IVP and detected unsuspected bladder invasion in 3 cases. 4. CT was valuable in thediagnosis of recurrent tumor and follow-up study after treatment. 5. CT offeres distinct advantages over clinicalstaging and can be integrated into the present FIGO classification of uterine cervix carcinoma. CT can served asan initial radiological staging work-up of primary of recurrent cervical carcinoma.
Cervix Uteri ; Chungcheongnam-do ; Classification ; Diagnosis ; Female ; Follow-Up Studies ; Humans ; Hydronephrosis ; Lymph Nodes ; Neoplasm Metastasis ; Urinary Bladder ; Uterine Cervical Neoplasms

PURPOSE: Acute febrile illness in children frequently accompanies with abdominal symptoms such as vomiting, diarrhea, and abdominal pain, even if its etiology is not occured from the gastrointestinal tract. If the etiology of fever was unknown and the fever was accompanied with abdominal symptoms, we should be concerned about whether the etiology of fever was originated from the gastrointestinal tract or interpretated from the abnormality in the gastrointestinal tract. This study was performed to evaluate the diagnostic value of abdominal ultrasonography in patients with fever and abdominal symptoms. METHODS: We reviewed retrospectively the medical records of abdominal ultrasonographic (US) findings of 60 cases of acute febrile illness with abdominal symptoms at department of Pediatrics, Ulsan Dongang General RESULTS: (100%), splenomegaly in 4 cases (66.7%), ileocecitis in 1 case (16.7%), enlarged mesenteric lymph nodes and splenomegaly in 4 cases (66.7%), enlarged mesenteric lymph nodes, splenomegaly and ileocecitis in 1 cases (16.7%). 6) The enlarged mesenteric lymph nodes and the abnormalities around the appendix were seen in 7 cases (11.7%), which were confirmed as appendicitis all. 7) The thickening of wall in urinary bladder was seen in 2 cases (3.3%) of acute cystitis and acute hemorrhagic cystitis. 8) The subtle thickening of wall in colon was seen in 1 cases (1.7%) of shigellosis. CONCLUSIONS: The enlarged mesenteric lymph nodes, splenomegaly and ileocolitis on the abdominal ultrasonography in patients with fever and abdominal symptoms aree suggestive findings of typhoid fever. The enlarged mesenteric lymph nodes and the abnormalities around the appendix on abdominal ultrasonography make the rapid diagnosis of acute appendicitis and its complications, when physical examination is difficult in small children and diagnosis of their illnesses is obscure in patients with fever and abdominal pain.
Abdominal Pain ; Appendicitis ; Appendix ; Child ; Colon ; Crohn Disease ; Cystitis ; Diagnosis ; Diarrhea ; Dysentery, Bacillary ; Fever* ; Gastrointestinal Tract ; Humans ; Lymph Nodes ; Medical Records ; Pediatrics ; Physical Examination ; Retrospective Studies ; Splenomegaly ; Typhoid Fever ; Ulsan ; Ultrasonography ; Urinary Bladder ; Vomiting

We studied clinically 33 in patients(48 eyes) of windshield ocular injuries among 72 in patients who had ocular injuries by traffic accidents and underwent surgical treatment in Department of Ophthalmology of Han Gang Sacred Heart Hospital from 1. Jan, 1980 to 31. July, 1987. The results of analysis were as follows: 1. The incidence of windshield ocular injuries was 45.8% of all the ocular injuries caused by traffic accident. 2. The incidence was more common in male(81.9%) and in the age of 4th decades(39.4%). 3. The incidence of bilateral ocular injuries was 45.3%. 4. The ocular injuries were more common in front right seats(54.5%) than driver's seats(45.5%). 5. Eyebll injuries occured in 77.1% and among them, corneoscleral laceration was most common. 6. There was no significant statiscal value of final visual acuity between laceration involvin the cornea only and laceration involving the cornea and anterior sclera. 7. Final V.A less than 0.1 was 43.7% and the most common cause of visual impairment was corneal opacity.
Accidents, Traffic ; Cornea ; Corneal Opacity ; Heart ; Humans ; Incidence ; Lacerations ; Ophthalmology ; Sclera ; Vision Disorders ; Visual Acuity

BACKGROUND: Enterococcus faecium (E. faecium) is potential pathogens of mixed infections for which a broad-spectrum antimicrobial agents such as imipenem has a therapeutic role. But controversy continues concerning testing imipenem versus enterococci. The purpose of this study were 1) to investigate the ability of penicillin and ampicillin minimum inhibitory concentration (MIC) to predict in vitro susceptibility of E. faecium versus imipenem. and 2) to compare MICs of ampicillin, penicillin and imipenem by the Vitek system with those by agar dilution method. METHODS: Fifty-two isolates of E. faecium between April 2002 and May 2002 were tested. Each isolate was tested versus penicillin, ampicillin and imipenem. MICs were determined by Vitek system and agar dilution method according to NCCLS guidelines. Imipenem MIC determinations were repeated by E-test. RESULTS: MIC of Vitek system tends to be lower than that of agar dilution method, but there was good concordance between MICs of penicillin and ampicillin by Vitek system and agar dilution method. But for imipenem, the MICs by the agar dilution method did not correspond with the Vitek results. Of the 52 E. faecium isolates tested, in vitro activity of penicillin and ampicillin accurately predicts that of imipenem. CONCLUSIONS: MICs of ampicillin and penicillin are reliable, but imipenem MIC is not reliable for E. faecium by Vitek system. In vitro activity of penicillin and ampicillin versus E. faecium accurately predicts that of imipenem.
Agar ; Ampicillin ; Anti-Infective Agents ; Coinfection ; Enterococcus faecium* ; Enterococcus* ; Imipenem* ; Microbial Sensitivity Tests ; Penicillins

BACKGROUND: With advances in the techniques of liver resection as well as with better improvement of preoperative and postoperative care, hepatic resections for liver disease have become more common. This study presents a review of our experience for hepatic resection and an analysis of potential risk factors affecting the morbidity and the mortality in a hepatectomy. METHOD: From 1970 to 1996, 506 patients underwent hepatic resections; 139 patients with benign hepatic diseases, 329 patients with primary hepatic malignancy, and 38 patients with secondary hepatic malignancy. RESULTS: We divided the patients into two groups. Group 1 had 272 patients (from 1970 to 1990), and group 2 had 234 patients (from 1991 to 1996). As compared with group 1, group 2 had more malignant diseases than non-malignant diseases as operative indications. In the patients resected for primary hepatic malignancy, the 1-, 2-, 3-, and 5-year survival rates were 56.6%, 36.7%, 30.1%, and 15.2%, respectively, and 1-, 2-, 3-, 4-, and 5-year survival rates for a hepatocellular carcinoma were 58.5%, 41%%, 30.1%, 25.3%, and 17.2% and for a cholangiocarcinoma 39.5%, 22.5%, 19%, 8.3%, and 5.2%, respectively. The overall operative mortality rate was 5.9% (30/506), 7.4% in group 1 and 4.3% in group 2. The significant risk factors for perioperative mortality were liver cirrhosis, jaundice, increase of postoperative alkaline phosphatase, extended time needed for operation (above 4 hours), massive transfusion during operation (above 5,000 cc), malnutrition and/or weight loss (above 10%), low hemoglobin (below 10 gm%) and low serum albumin level (below 3.0 gm). Also, the major complicationsinfluencing perioperative mortality were liver failure, perioperative hemorrhage, cholangitis, intraabdominal abscess, sepsis, pulmonary lesions, and renal failure. CONCLUSION: After 1990, minor resections having enough margin from the hepatic malignant lesion have increased. However there has been no difference in the survival rate compared with that for a major resection for hepatic malignant diseases. Rather, operative morbidity, perioperative mortality, and postoperative complications have decreased in favor of a minor resection for hepatic malignant diseases.
Abscess ; Alkaline Phosphatase ; Carcinoma, Hepatocellular ; Cholangiocarcinoma ; Cholangitis ; Hemorrhage ; Hepatectomy ; Humans ; Jaundice ; Liver ; Liver Cirrhosis ; Liver Diseases ; Liver Failure ; Malnutrition ; Mortality ; Postoperative Care ; Postoperative Complications ; Renal Insufficiency ; Risk Factors* ; Sepsis ; Serum Albumin ; Survival Rate ; Weight Loss