Total cystectomy was performed to the 40 patients with urinary bladder tumor who were found perivesical fat infiltration by computerized tomography. 25 patients were previously untreated, and 15 patients had undergone transurethral resection or biopsy of the tumor before computerized tomography. The histopathological stage was compared to the preoperative computerized tomography stage. In pathologic specimen, perivesical fat infiltration was found in 62.5% of the cases, whereas perivesical fat infiltration was not found in 37.5% of the cases. In untouched tumors or after transurethral resection computerized tomography accuracy demonstrated no significant difference.
Biopsy ; Cystectomy ; Humans ; Urinary Bladder Neoplasms* ; Urinary Bladder*

No abstract available.
Anxiety* ; Depression* ; Headache*

Intersex is the state of having ambiguous or inappropriate genitalia due to abnormalities of normal mechanisms for sexual development. Three broad subcategories of intersex have been defined according to the histology of the gonad: Female & male pseudohermaphroditism and true hermaphroditism. Twenty two cases of intersex are described. Among them, true hermaphroditism was 7 cas-es, female pseudohermaphroditism 10 cases and male pseudohermaphroditism 5 cases. The presenting symptoms, age of diagnosis, gender role, histologic findings of gonad & tre-atment are discussed. Review of literature and reference on intersex was attempted briefly.
46, XX Disorders of Sex Development ; 46, XY Disorders of Sex Development ; Diagnosis ; Female ; Gender Identity ; Genitalia ; Gonads ; Humans ; Ovotesticular Disorders of Sex Development ; Sexual Development

No abstract available.
Hypopituitarism*

Iliac artery aneurysm is rare disease. We report a 60-year-old man who was referred to our hospital because of right hydronephrosis and pelvic mass. A intravenous pyelogram, a computerized tomography scan and a magnetic resonance imaging revealed a pelvic sarcoma. We experienced a case of right internal iliac artery aneurysm masquerading as pelvic sarcoma.
Aneurysm* ; Humans ; Hydronephrosis ; Iliac Artery* ; Magnetic Resonance Imaging ; Middle Aged ; Rare Diseases ; Sarcoma*

The synchronous presentation of two separate neoplasms is extremely unusual. In 1921, Graves and Temleton first discovered synchronous two neoplasms in the same kidney. However, almost all reported synchronous tumors arising in a same kidney have been renal cell carcinoma and transitional cell carcinoma. We report a case report of a synchronous renal cell carcinoma and adult Wilms' tumor in a same kidney in a 41-year-old woman which was managed by radical nephrectomy and combination chemotherapy.
Adult* ; Carcinoma, Renal Cell* ; Carcinoma, Transitional Cell ; Drug Therapy, Combination ; Female ; Humans ; Kidney* ; Nephrectomy ; Wilms Tumor*

Hemodynamics in 60 normal, 15 simple goiter and 40 hyperthyroid subjects were determined from non-invasive Wezler's method. Hemodynamic changes in hyperthyroid patients were compared with those of normal subjects. The relationships of the cardiac output, aging,131I uptake rate and PEP/LVET to the hemodynamic changes in Hyperthyroid patients were also discussed. 1) The hemodynamics of normal subjects were same as those of simple goiter. 2) The heart rate and cardiac output were increased very significantly in hyperthyroid patients but they appeared to decrease with age. The stroke volume was increased slightly in the hyperthyroid patients, but remained unlateerd even with aging. Peripheral arterial resistance in hyperthyroid patients was decreased but appeared to increase with age. 3) As the131I uptake rate increased, the heart rate, cardiac output also increased, but PEP/LVET as an index of myocardial contractility and the peripheral arterial resistance decreased. 4) PEP/LVET as an index of myocardial contractility in hyperthyroid patients was markedly reduced. 5) The relationship of stroke volume and the rate of the heart to cardiac output in normal subjects were reasonably linear, and peripheral arterial resistance has negative relation to cardiac output. However the heart rate, though increased in most patients with thyrotoxicosis, bears no close relations to the level of cardiac output increment. The relationshop of stroke volume to cardiac output in hyperthyroid patients is reasonably linear and peripheral arterial resistance has negative correlation with the cardiac output.
Aging ; Cardiac Output ; Goiter ; Heart ; Heart Rate ; Hemodynamics* ; Humans ; Stroke Volume ; Thyrotoxicosis

Although genitourinary leiomyoma may arise in any anatomic structure containing smooth muscle, primary leiomyoma of the bladder is rare. This tumor is usually asymptomatic unless urinary tract function is affected. We experienced a case of leiomyoma of the bladder with back pain in a 42 year old woman.
Adult ; Back Pain* ; Female ; Humans ; Leiomyoma* ; Muscle, Smooth ; Urinary Bladder* ; Urinary Tract

No abstract available.
Body Mass Index* ; Pregnancy* ; Weight Gain*

BACKGROUND AND OBJECTIVES: Unlike the normal skin, cholesteatomas characterized by hyperproliferative keratinocytes exhibits up-regulation of connexins (Cxs) and gap junctional intercellular communication (GJIC). Currently, there are no appropriate clinical methods that can inhibit cholesteatoma progression nor are there available optimal in vitro models of cholesteatomas. The objectives of this study were to identify the regulating materials that control GJIC using human keratinocyte cells (HaCaT) and to get preliminary information about how to inhibit cholesteatoma progression with an aim to make in vitro models. MATERIALS AND METHOD: Acetic acid (AA), H2O2, dexamethasone, retinoic acid (RA), or green tea extracts-epicatechin (EC) and epigallocatechin gallate (EGCG) were used for this study. After HaCaT cells were cultured with chemicals for 24 hours, cytotoxicity was quantitatively analyzed by cell counting and Neutral-red uptake test. Reverse transcriptase-polymerase chain reaction, Western blot and immunocytochemistry were performed to analyze the change of Cx expression. GJIC was functionally evaluated with scrape-loading dye transfer (SLDT). RESULTS: After the 24-hour culture, H2O2 or EGCG (100 microM) were observed to have interfered with cell growth. In the Western blot, Cx26 and Cx30 showed higher up-regulation by EGCG or dexamethasone, but less down-regulation by AA or H2O2 than the control. In comparison with the control, immunocytochemistry (Cx26, Cx43) showed less expression and abnormal location of Cxs under AA, H2O2, or 50 microM EGCG than the control, and increased up-regulation or equal expression under 5microM EGCG, EC, RA, or dexamethasone was greater than the control. In SLDT, dye transfer was significantly lower in AA-, H2O2-, dexamethasone-, or RA-treated cells than in the control cells. EC showed higher dye transfer than the control cells. CONCLUSION: The expression of Cxs and GJIC on human HaCaT keratinocytes can be up- or down-regulated by chemicals such as AA, H2O2, dexamethasone, or EC. These results may be useful information in understanding the progression or inhibition mechanisms of cholesteatomas.
Acetic Acid ; Blotting, Western ; Catechin ; Cell Count ; Cholesteatoma ; Connexins ; Dexamethasone ; Down-Regulation ; Gap Junctions ; Humans ; Immunohistochemistry ; Keratinocytes ; Skin ; Tea ; Tretinoin ; Up-Regulation