1.Intermittent Administration of Parathyroid Hormone for Orthodontic Tooth Movement in Mongrel Dogs: Preliminary Study
Won-Ho KIM ; Bo Ram LEE ; Hey-Yun KIM ; Minji KIM ; Jin-Woo KIM
Journal of Korean Dental Science 2023;16(2):182-191
Purpose:
This study investigated the orthodontic tooth movement after weekly parathyroid hormone (PTH) injection in mongrel dogs and analyzes bone formation activity on the tension and pressure sides of the tooth movement in mongrel dogs.
Materials and Methods:
Three mongrel dogs were used in this study. The first premolar was extracted and orthodontic force using 150 g of closed coil springs between the canine and second premolar was applied. The low-dose PTH group (PTH_1) and high-dose PTH group (PTH_2) received weekly injections of 1.61 μg/kg and 3.23 μg/kg of PTH, respectively. The control group received weekly injections of 1 ml of saline. Clinical, histomorphometric analysis were carried out.Result: The orthodontic tooth movement was greatest in the PTH_2 group and the lowest in the control group. Fluorescence staining images showed higher bone remodeling on the tension side of the tooth movement in the PTH_1 and PTH_2 groups. PTH_2 group showed a thicker labeling band than the PTH_1 group. PTH_2 group showed the highest mineral apposition rate and bone formation rate, followed by the PTH_1 group and the control group.
Conclusion
Weekly intermittent PTH injection, especially in the short-term and at higher doses with orthodontic force, successfully increased orthodontic tooth movement and bone remodeling in mongrel dogs.
2.Impact of coronavirus disease 2019 on patients with chronic pain: multicenter study in Korea
Hyunji JOHN ; Hyunji JOHN ; Yun Hee LIM ; Yun Hee LIM ; Sung Jun HONG ; Sung Jun HONG ; Jae Hun JEONG ; Jae Hun JEONG ; Hey Ran CHOI ; Hey Ran CHOI ; Sun Kyung PARK ; Jung Eun KIM ; Byung-soo KIM ; Jae Hun KIM
The Korean Journal of Pain 2022;35(2):209-223
Background:
The coronavirus disease 2019 (COVID-19) pandemic has caused significant changes. This study aimed to investigate the impact of COVID-19 on patients with chronic pain.
Methods:
Patients with chronic pain from 23 university hospitals in South Korea participated in this study. The anonymous survey questionnaire consisted of 25 questions regarding the following: demographic data, diagnosis, hospital visit frequency, exercise duration, time outside, sleep duration, weight change, nervousness and anxiety, depression, interest or pleasure, fatigue, daily life difficulties, and self-harm thoughts. Depression severity was evaluated using the Patient Health Questionnaire-9 (PHQ-9). Logistic regression analysis was used to investigate the relationship between increased pain and patient factors.
Results:
A total of 914 patients completed the survey, 35.9% of whom had decreased their number of visits to the hospital, mostly due to COVID-19. The pain level of 200 patients has worsened since the COVID-19 outbreak, which was more prominent in complex regional pain syndrome (CRPS). Noticeable post-COVID-19 changes such as exercise duration, time spent outside, sleep patterns, mood, and weight affected patients with chronic pain. Depression severity was more significant in patients with CRPS. The total PHQ-9 average score of patients with CRPS was 15.5, corresponding to major depressive orders. The patients’ decreased exercise duration, decreased sleep duration, and increased depression were significantly associated with increased pain.
Conclusions
COVID-19 has caused several changes in patients with chronic pain.During the pandemic, decreased exercise and sleep duration and increased depression were associated with patients’ increasing pain.
3.Sufficient explanation of management affects patient satisfaction and the practice of post-treatment management in spinal pain, a multicenter study of 1007 patients.
Jae Yun KIM ; Jae Hang SHIM ; Sung Jun HONG ; Jong Yeun YANG ; Hey Ran CHOI ; Yun Hee LIM ; Ho Sik MOON ; Jaemoon LEE ; Jae Hun KIM
The Korean Journal of Pain 2017;30(2):116-125
BACKGROUND: Spinal pain is most common symptom in pain clinic. In most cases, before the treatment of spinal pain, physician explains the patient's disease and treatment. We investigated patient's satisfaction and physician's explanation related to treatments in spinal pain patients by questionnaires. METHODS: Anonymous questionnaires about physician's explanation and patient's satisfaction in each treatment and post-treatment management were asked to individuals suffering from spinal pain. Patients who have spinal pain were participated in our survey of nationwide university hospitals in Korea. The relationships between patient's satisfaction and other factors were analyzed. RESULTS: Between June 2016 and August 2016, 1007 patients in 37 university hospitals completed the questionnaire. In the statistical analysis, patient's satisfaction of treatment increased when pain severity was low or received sufficient preceding explanation about nerve block and medication (P < 0.01). Sufficient explanation increased patient's necessity of a post-treatment management and patients' performance rate of post-treatment management (P < 0.01). CONCLUSIONS: These results show that sufficient explanation increased patients' satisfaction after nerve block and medication. Sufficient explanation also increased the practice of patients' post-treatment management.
Anonyms and Pseudonyms
;
Hospitals, University
;
Humans
;
Korea
;
Nerve Block
;
Pain Clinics
;
Patient Satisfaction*
4.Perioperative Pain Management in the Patient with Complex Regional Pain Syndrome: A case report.
Ji Yon JO ; Mi Geum LEE ; Hyo Min LEE ; Yun Suk CHOI ; Hey Jeong YUN ; Chul Joong LEE ; Sang Chul LEE ; Yong Chul KIM
The Korean Journal of Pain 2006;19(2):218-222
Complex regional pain syndrome (CRPS) is a syndrome of pain and sudomotor or vasomotor instabilities. The perioperative pain management in CRPS patients is very important, as surgery can aggravate preexisting symptoms, especially when performed around the lesion site. Despite the increasing interest in CRPS research, little is known about the optimal perioperative treatment strategy for CRPS patients. Herein, the case of a female CRPS patient, who underwent elective surgery at the lesion site, is reported. As a preemptive analgesia, the patient was satisfactorily managed with two weeks of patient-controlled epidural analgesia, initiated 2 days prior to surgery. The techniques for the prevention of perioperative pain, including preemptive analgesia, as well as its importance, are discussed.
Analgesia
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Analgesia, Epidural
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Female
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Humans
;
Pain Management*
5.Actual situation and prescribing patterns of opioids by pain physicians in South Korea
Min Jung KIM ; Ji Yeon KIM ; Yun Hee LIM ; Sung Jun HONG ; Jae Hun JEONG ; Hey Ran CHOI ; Sun Kyung PARK ; Jung Eun KIM ; Min Ki LEE ; Jae Hun KIM
The Korean Journal of Pain 2022;35(4):475-487
Background:
Use of opioids for chronic intractable pain is increasing globally, and their proper use can improve patients’ quality of life. In contrast, opioid use disorders, such as abuse or addiction, caused by prescribing opioids, are a worldwide issue. This study aimed to understand current opioid prescribing patterns and pain physicians’ experiences with opioid use in South Korea.
Methods:
Pain physicians in 42 university hospitals in South Korea were asked to complete anonymous questionnaires regarding opioid prescriptions.
Results:
A total of 69 surveys were completed. Most pain physicians started prescribing opioids at a pain score of 7/10 and aimed to reduce pain by 50%. Most physicians (73.1%) actively explained the prescribed medications and possible side effects, and 61.2% of physicians preferred the prescription interval of 4 weeks.Immediate-release opioids were the most popular treatment for breakthrough pain (92.6%). The most common side effect encountered by physicians was constipation (43.3%), followed by nausea/vomiting (34.3%). Of the physicians, 56.5% replied that addiction and misuse prevalences were less than 5%. However, the most concerning side effect was addiction (33.0%).
Conclusions
The survey results showed that the prescribing patterns of pain physicians generally followed Korean guidelines. Physicians were most interested in the safety and effectiveness of opioid prescriptions. They were most concerned about respiratory depression and abuse or addiction. A significant number of physicians agreed that the NHIS regulations needed improvement for patient convenience and safe and effective treatment, though there were pros and cons of the NHIS restrictions on prescription conditions.
6.Evaluation of the association between pollen count and the outbreak of allergic disease.
Ha Na KANG ; Hey Suk YUN ; Young Jin CHOI ; Jae Won OH ; Ui Young MIN ; Yoon Sook HEO ; Young Seop LEE ; Mijin KIM ; Kyu Rang KIM ; Baek Jo KIM
Allergy, Asthma & Respiratory Disease 2016;4(6):415-422
PURPOSE: This study focused on the evaluation of the relation between pollen concentration and the outbreak of allergic disease (symptom index), and this outcome would be necessary to upgrade risk grade for the pollen forecasting system. METHODS: Airborne particles carrying allergens, such as pollen, were collected daily at the Seoul and Guri area by using 7-day Burkard samplers for 6 years. A total of 596 Subjects were recruited from Hanyang University Seoul Hospital (n=144 for spring, n=139 for autumn), and Hanyang University Guri Hospital (n=157 for spring, n=156 for autumn). Symptom index was evaluated and recorded by phone calling to study subjects daily or asking questionnaire when they visit outpatient clinic every week. Statistical analysis of data was performed by using correlation coefficients and regression models with time series graph. RESULTS: Two peak seasons of pollen concentration were May and September in Korea. In skin prick tests, the sensitization rate to ragweed pollen was gradually increased in children. In the same period, sensitization rates to airborne pollen, especially oak, birch for spring, and Japanese hop for autumn were increased annually. There was a significantly relationship between symptom index of allergic patients and allergic pollen concentrations in this study. Especially symptom index was significantly correlated to the concentration of oak pollen of day 1 in spring and to the concentration of Japanese hop pollen of day 0 in autumn. CONCLUSION: Sensitization rates to pollens increased annually. There is a significant relationship between allergy symptom index and pollen concentration. There remains to confirm the Korean own risk grade of pollen allergy.
Allergens
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Ambrosia
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Ambulatory Care Facilities
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Asian Continental Ancestry Group
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Betula
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Child
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Forecasting
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Humans
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Hypersensitivity
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Korea
;
Pollen*
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Rhinitis, Allergic, Seasonal
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Seasons
;
Seoul
;
Skin
7.Patients’ perception about opioids and addiction in South Korea
Cho Long KIM ; Sung Jun HONG ; Yun Hee LIM ; Jae Hun JEONG ; Ho Sik MOON ; Hey Ran CHOI ; Sun Kyung PARK ; Jung Eun KIM ; Hakjong YOU ; Jae Hun KIM
The Korean Journal of Pain 2020;33(3):234-244
Background:
Chronic pain affects approximately 22% of the world’s population. Opioids can be useful in chronic pain management. However, some patients have negative perception of opioids. The purpose of this research was to evaluate patients’ perception about opioids and investigate problems associated with prescribing and taking opioids in South Korea.
Methods:
Patients who visited a pain clinic in 14 university hospitals of South Korea from September through October 2018 were asked to complete anonymous questionnaires about taking opioids.
Results:
Of the 368 patients that were surveyed (female 53.3%, male 46.7%), 56.8% were prescribed opioids. In the opioid group, 92.8% patients had heard of opioids from their doctor and 72.6% of them had a positive perception about opioids. The side effects associated with opioid use were constipation (35.4%), dizziness (24.6%), nausea and vomiting (17.4%), dysuria (6.2%), and addiction (2.0%). In the no opioid group, the primary sources of information about opioids were doctors (49.2%), mass media (30.8%), and the internet (16.2%). The main reasons why 39.0% patients did not take opioids were fear of addiction (57.7%) and side effects (38.5%). There were 71.5% and 60.9% patients in the opioid and no opioid group, respectively, who wished to take opioids when their numeric rating scale pain score was ≥ 7.
Conclusions
Perception of opioids among patients who take them was either neutral or positive. However, 39.0% patients who have not been prescribed opioids did not want an opioid prescription, citing fear of addiction and side effects as the primary reasons.
9.The development of patient-tailored asthma prediction model for the alarm system.
Hey Suk YUN ; Wee Jin RAH ; Young Jin CHOI ; Joo Hwa KIM ; Jae Won OH ; Hyun Hee KIM ; Yoon Seok CHANG ; Kwang Ha YOO ; Keon Tae SOHN
Allergy, Asthma & Respiratory Disease 2016;4(5):328-339
PURPOSE: The increased incidence of asthma due to rising allergic diseases requires the prevention of worsening asthma. It is necessary to develop a patient-tailored asthma prediction model. METHODS: We developed causative factors for the asthma forecast system: infant and young children (0–2 years), preschool children (3–6 years), school children and adolescents (7–18 years), adults (19–64 years), old aged adult (>64 years). We used the Emergency Department code data which charged the short-acting bronchodilator (Salbutamol sulfate) from Health Insurance Review and Assessment Service for the development of asthma prediction models. Three kinds of statistical models (multiple regression models, logistic regression models, and decision tree models) were applied to 40 study groups (4 seasons, 2 sex, and 5 age groups) separately. RESULTS: The 3 kinds of models were compared based on model assessment measures. Estimated logistic regression models or decision tree models were recommended as binary forecast models. To improve the predictability, a threshold was used to generate binary forecasts. CONCLUSION: We suggest the binary forecast models as a patient-tailored asthma prediction system for this category. It may be needed the extended study duration and long-term data analysis for asthmatic patients for the further improvement of asthma prediction models.
Adolescent
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Adult
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Asthma*
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Child
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Child, Preschool
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Decision Trees
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Emergency Service, Hospital
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Humans
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Incidence
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Infant
;
Insurance, Health
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Logistic Models
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Models, Statistical
;
Seasons
;
Statistics as Topic
10.Idiopathic severe hypermagnesemia in an extremely low birth weight infant on the first day of life.
Hye Sun HYUN ; Hyun Sin CHOI ; Jin Kyu KIM ; So Yoon AHN ; Hey Soo YOO ; Eun Sun KIM ; Yun Sil CHANG ; Won Soon PARK
Korean Journal of Pediatrics 2011;54(7):310-312
A preterm female infant born at 27 weeks of gestation with a birth weight of 990 g developed acute hypotonia, apnea, hypotension and bradycardia mimicking septic shock syndrome at 14h after birth. Laboratory tests indicated a severe hypermagnesemia of 45 mg/dL. The renal function, complete blood count and maternal blood concentrations of magnesium were normal, and the blood cultures were negative. The patient recovered with treatment including exchange transfusion. However, the etiology of the severe hypermagnesemia remains unknown.
Apnea
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Birth Weight
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Blood Cell Count
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Bradycardia
;
Female
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Humans
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Hypotension
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Infant
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Infant, Extremely Low Birth Weight
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Infant, Newborn
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Magnesium
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Muscle Hypotonia
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Parturition
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Pregnancy
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Shock, Septic