No abstract available.

OBJECTIVES: The purpose of this investigation was to evaluate the remineralization effect of CPP-ACP, NaF, bamboo salt and NaF+bamboo salt solutions on bovine incipient artificial enamel caries by microcomputed tomography (micro CT). METHODS: Specimens were prepared from extracted bovine teeth and immersed in a demineralizing solution for 72 h. Specimens were divided into five groups of five specimens each by randomized blocks according to surface microhardness (VHN) and mineral density. The specimens were each treated by one of the following agents for 24 h: distilled water, 2% sodium fluoride solution (2% NaF group), 3% bamboo salt solution (3% BS group), and a solution of 2% sodium fluoride solution and 3% bamboo salt solution mixed together (2% NaF+3% BS group) and 1% CPP-ACP solution. After this, the specimens were immersed in artificial saliva for 15 and 30 days. After 15 days and 30 days treatment, VHN and mineral density values (g/cm3) were measured and analysed. Mineral density values were obtained using micro CT. RESULTS: Mineral density and VHN of the five groups according to the immersion period in artificial saliva showed statistically significant differences (P<0.05). In mineral density and VHN, the values of the 2% NaF+3% BS group were significantly higher than those of the other groups, and there were no significant differences among the 2% NaF, 3% BS, CPP-ACP groups after 30 days. CONCLUSIONS: Bamboo salt showed a similar remineralization pattern to CPP-ACP on an incipient artificial enamel caries lesion. Thus, bamboo salt (like CPP-ACP) can act as a remineralization agent for subsurface lesions of incipient enamel caries.
Caseins ; Dental Enamel ; Immersion ; Saliva, Artificial ; Sodium ; Sodium Fluoride ; Tooth ; Water ; X-Ray Microtomography

OBJECTIVES: The purpose of this study was to evaluate the dental erosion inhibitory effect of hangover beverage containing calcium and fluoride. METHODS: Risk factors of dental erosion in the varying concentrations of fluoride, Ca, P, pH, and the buffer capacity were measured in six groups of mixture: distilled water, Morning care, Morning care adding 3% calcium, Morning care adding 5% calcium, Morning care adding 4 ppm F, Morning care adding 3% calcium and 4 ppm F. Seventy two specimens were prepared for the microhardness tests and divided randomly into 6 groups (n=12). Each group was exposed to the six groups of the mixture for 1, 3, 5, 10, 15, 30 min. Surface microhardness was measured before and after the treatment, and the surface was observed by SEM after the treatment only. RESULTS: After 30 minutes of treatment, the surface microhardness changes were significantly different among the six groups: Distilled water (0.11+/-1.98 DeltaVHN), Morning care (100.49+/-9.66 DeltaVHN), Morning care+3% calcium (17.07+/-8.45 DeltaVHN), Morning care+5% calcium (10.35+/-7.61 DeltaVHN), Morning care+4 ppm F (93.96+/-15.13 DeltaVHN), Morning care+3% calcium+4 ppm F (14.21+/-7.97 DeltaVHN) (P<0.01). The three groups, including those treated with the mixtures of Morning care+3% calcium, Morning care+5% calcium, and Morning care+3% calcium+4 ppm F, showed no statistically significant difference on the surface microhardness change and inhibition effect on enamel erosion (P>0.05) when compared with the distilled water group. CONCLUSIONS: It is suggested that modification of the Morning care with 3% calcium could be useful for a significant protective potential with respect to dental erosion.
Beverages ; Calcium ; Dental Enamel ; Fluorides ; Hydrogen-Ion Concentration ; Risk Factors ; Water

No abstract available.
Testis*

Purpose: Tumor radioresistance and dose-limiting toxicity restrict the curative potential of radiotherapy, requiring novel approaches to overcome the limitations and augment the efficacy. Here, we investigated the effects of signal transducer and activator of transcription 3 (STAT3) activation and autophagy induction by irradiation on antiapoptotic proteins and the effectiveness of the BH3 mimetic ABT-737 as a radiosensitizer using K-ras mutant non-small cell lung cancer (NSCLC) cells and a Kras G12D :p53 fl/fl mouse (KP mouse) model. Materials and Methods: A549 and H460 cells were irradiated, and the expression of Bcl-2 family proteins, JAK/STAT transcriptional pathway, and autophagic pathway were evaluated by immunoblotting. The radiosensitizing effects of ABT-737 were evaluated using A549 and H460 cell lines with clonogenic assays and also by a KP mouse model with microcomputed tomography and immunohistochemistry. Results: In A549 and H460 cells and mouse lung tissue, irradiation-induced overexpression of the antiapoptotic molecules BclxL, Bcl-2, Bcl-w, and Mcl-1 through JAK/STAT transcriptional signaling induced dysfunction of the autophagic pathway. After treatment with ABT-737 and exposure to irradiation, the number of surviving clones in the cotreatment group was significantly lower than that in the group treated with radiation or ABT-737 alone. In the KP mouse lung cancer model, cotreatment with ABT-737 and radiation-induced significant tumor regression; however, body weight changes in the combination group were not significantly different, suggesting that combination treatment did not cause systemic toxicity. Conclusion These findings supported the radiosensitizing activity of ABT-737 in preclinical models, and suggested that clinical trials using this strategy may be beneficial in K-ras mutant NSCLC.

Angiomyolipoma arising from the liver is a rare primary benign lipomatous tumor of the lever. We experienced a case of surgically proven hepatic angiomyolipoma, which was preoperatively diagnosed by definning of its characteristic histologic components and benign radiologic nature with various imaging modalities including ultrasound, dynamic computed tomography, angiography, and magnetic resonance imaging. It was the first reported case in the world that full radiologic evaluation was taken and internal vascular proliferation was defined by using dynamic bolus CT prior to angiography.
Angiography ; Angiomyolipoma* ; Liver* ; Magnetic Resonance Imaging ; Ultrasonography

Angiomyolipoma arising from the liver is a rare primary benign lipomatous tumor of the lever. We experienced a case of surgically proven hepatic angiomyolipoma, which was preoperatively diagnosed by definning of its characteristic histologic components and benign radiologic nature with various imaging modalities including ultrasound, dynamic computed tomography, angiography, and magnetic resonance imaging. It was the first reported case in the world that full radiologic evaluation was taken and internal vascular proliferation was defined by using dynamic bolus CT prior to angiography.
Angiography ; Angiomyolipoma* ; Liver* ; Magnetic Resonance Imaging ; Ultrasonography

Background/Aims: Tegoprazan, a novel potassium-competitive acid blocker, has shown rapid action and gastric acid inhibition. In this study, we evaluated the efficacy of a tegoprazan-based, nonbismuth-containing quadruple (concomitant) therapy for the primary eradication of Helicobacter pylori. Methods: We conducted a prospective, single-arm, single-center, primitive study to verify the efficacy of a 10-day tegoprazan- based (50-mg dose) concomitant therapy, including amoxicillin (1,000-mg dose), clarithromycin (CLA; 500-mg dose), and metronidazole (MET; 500-mg dose) twice daily as a first-line treatment for H. pylori eradication. Results: We tested consecutive cultures for antibiotic susceptibility and minimum inhibitory concentrations. We enrolled 84 participants; 79 (94.0%) completed first-line therapy. The overall intention-to-treat and per-protocol eradication rates were 90.5% (95% confidence interval [CI], 82.1−95.8) and 96.2% (95% CI, 83.4–97.6), respectively. Of the 73 participants evaluated for antibiotic resistance, 19 (26.0%), 32 (42.5%), and 8 (11.0%) exhibited CLA, MET, and CLA and MET dual resistance, respectively. Of these, 39 participants (66.1%) exhibited successful eradication after the therapeutic regimen despite antibiotic resistance. Conclusions The 10-day tegoprazan-based concomitant therapy may be an effective first-line treatment for eradicating H. pylori.

Purpose: This study investigated the orthodontic tooth movement after weekly parathyroid hormone (PTH) injection in mongrel dogs and analyzes bone formation activity on the tension and pressure sides of the tooth movement in mongrel dogs. Materials and Methods: Three mongrel dogs were used in this study. The first premolar was extracted and orthodontic force using 150 g of closed coil springs between the canine and second premolar was applied. The low-dose PTH group (PTH_1) and high-dose PTH group (PTH_2) received weekly injections of 1.61 μg/kg and 3.23 μg/kg of PTH, respectively. The control group received weekly injections of 1 ml of saline. Clinical, histomorphometric analysis were carried out.Result: The orthodontic tooth movement was greatest in the PTH_2 group and the lowest in the control group. Fluorescence staining images showed higher bone remodeling on the tension side of the tooth movement in the PTH_1 and PTH_2 groups. PTH_2 group showed a thicker labeling band than the PTH_1 group. PTH_2 group showed the highest mineral apposition rate and bone formation rate, followed by the PTH_1 group and the control group. Conclusion Weekly intermittent PTH injection, especially in the short-term and at higher doses with orthodontic force, successfully increased orthodontic tooth movement and bone remodeling in mongrel dogs.

OBJECTIVE: To estimate the effect of maternal age on obstetric outcomes, a retrospective analysis was done. METHODS: Twenty six hundred and forty six women who delivered a singleton baby at our hospital from January 1, to December 31, 2004 were enrolled in this study. Subjects were divided into 3 age groups; 1) less than 35 years, 2) 35-39 years, and 3) 40 years and older. Chi-square test was used to assess the effect of age on obstetrics outcome. Then the odds ratio was calculated to represent clinically meaningful risk. RESULTS: A total of 2646 women with complete data were available; 2245 (84.9%) less than 35 years of age; 350 (13.2%) 35-39 years; and 51 (1.9%) 40 years and older. Increasing age was significantly associated with chromosomal abnormalities (OR 3.9and 8.8 for ages 35-39 years and age 40 years and older, respectively), Preterm premature rupture of membranes (OR 1.3 and 3.2) and cesarean delivery (OR 2.0 and 5.5). Patients aged 35-39 years were at increased risk for placenta previa (OR 1.8) and congenital anomaly (OR 2.8) but these were not statistically significant. The rate of the preterm delivery was increased by age (OR 1.3 and 1.9 for ages 35-39 years and age 40 years and older, respectively) but it was not statistically significant (p=0.121). We did not find advanced maternal age to be associated with a statistically increased risk for preeclampsia, congenital anomaly, gestational diabetes, placenta abruption, low birth weight, macrosomia, neonatal morbidity (NICU admission), and perinatal loss. CONCLUSION: In conclusion, although the likelihood of adverse outcomes increases with maternal age, patients and obstetric care providers can be reassured that overall maternal and fetal outcomes are favorable in this patient population.
Chromosome Aberrations ; Diabetes, Gestational ; Female ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Maternal Age ; Membranes ; Obstetrics ; Odds Ratio ; Placenta ; Placenta Previa ; Pre-Eclampsia ; Pregnancy ; Pregnancy Outcome* ; Pregnancy* ; Retrospective Studies ; Rupture