As the core of cellular immunotherapy, T cells are important aspects of research and treatment of lung cancer. IL-6 is a costimulatory signal factor of T cells that is directly targeted by lung cancer stem cells. As a highly expressed cytokine in lung cancer cells, IL-6 plays an important role in variety of biological activities such as tumor occurrence, development, invasion and metastasis. This article reviews the research progress on IL-6 in lung cancer, including cancer development and progression, and the therapeutic sensitivity of lung cancer.
Disease Progression ; Humans ; Interleukin-6 ; metabolism ; Lung Neoplasms ; physiopathology ; Neoplastic Stem Cells ; pathology ; Research ; trends ; T-Lymphocytes ; metabolism