1.Investigation of determination of 2, 5-acetyl butyryl in blood and biological limit value for occupational exposure to -hexane.
Ridong CAI ; Linghui LIU ; Suying GU ; Qianhuai XIE ; Fei TANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2014;32(6):460-461
Hexanes
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Hexanones
;
blood
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Humans
;
Occupational Exposure
2.Progress on the mechanism of n-hexane induced toxic effects in vitro and in vivo.
Lian Jing ZHANG ; Wen Ting FENG ; Jian Jun LIU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2023;41(5):388-396
Hexane is a widely used organic solvent in industry, and chronic hexane poisoning is the main occupational toxic lesion in China. In particular, axonal and myelin lesions in the distal thick fibers of the peripheral nervous system may be caused by 2, 5-hexanedione (2, 5-HD), an intermediate metabolite of n-hexane in humans. Hexane has toxic effects not only on the nervous system but also on the liver, kidneys, and reproductive organs. In this paper, we review the progress of research on the mechanism of n-hexane toxic neuropathy.
Humans
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Hexanes/toxicity*
;
Hexanones
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Industry
;
Solvents
3.Analysis of volatile organic components of organic solvents used in Bao'an District of Shenzhen.
Li Hua WANG ; Zhi Liang ZHU ; Zhi Teng DAI ; Jing FENG ; Shao Fan WENG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2022;40(11):867-871
Objective: To understand the volatile organic components in the organic solvents used by enterprises in Baoan District, Shenzhen. Methods: From January to December 2020, a total of 541 organic solvent samples used by 86 companies were collected for volatile organic component analysis, and the main volatile components and high-risk occupational hazards in organic solvents used in different industries were analyzed. Results: A total of 201 volatile organic components were detected in 541 organic solvents. The top 5 components detected include xylene (29.76%, 116/541), toluene (21.81%, 118/541), methanol (20.70%, 112/541), n-hexane (14.79%, 80/541) and ethylbenzene (14.23%, 77/541). The detection rates of benzene, trichloroethylene, n-hexane, and 1, 2-dichloroethane, which were high-risk occupational hazards, were 2.40% (13/541), 3.70% (20/541), 14.79% (80/541), and 1.66% (9/541), respectively. The volatile components in organic solvents used in different industries was different. Benzene is more frequently detected in organic solvents used in the printing industry, trichloroethylene was more frequently detected in organic solvents used in the electronics industry, and n-hexane was more commonly found in organic solvents used in the electronics industry, printing and other industries, and 1, 2-dichloroethane has been more frequently detected in organic solvents used in the machinery industry. Conclusion: There are many types of organic solvents used by enterprises in Bao'an District, with complex components and differences in different industries.
Benzene/analysis*
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Hexanes
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Solvents
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Industry
;
Trichloroethylene
6.Focus on occupational disease monitoring results analysis of Bao'an district, Shenzhen in 2011 to 2012.
Su-li ZHANG ; Zhi-liang ZHU ; Xin-tian YU ; Jian-ping YANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2013;31(7):513-514
China
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epidemiology
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Hexanes
;
toxicity
;
Humans
;
Occupational Diseases
;
epidemiology
;
Trichloroethylene
;
toxicity
7.Investigation on occupational norma hexane poisoning accident in population.
Zu-ying HU ; Jian-yong CHEN ; Ning-xiang ZHANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2006;24(7):447-447
Accidents, Occupational
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Adolescent
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Adult
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Female
;
Hexanes
;
poisoning
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Humans
;
Male
8.Clinical analysis on 62 cases of subacute n-hexane poisoning.
Jian-jie ZHANG ; Jie SITU ; Li-hua DENG ; Shao-hong QIU ; Zhi-jun CHEN ; Jin-lin WANG ; Hui LI ; Zhi-min LI
Chinese Journal of Industrial Hygiene and Occupational Diseases 2013;31(8):622-623
Acute Disease
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Adolescent
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Adult
;
Female
;
Hexanes
;
poisoning
;
Humans
;
Male
;
Prognosis
;
Young Adult
9.Analysis of cell parameter in peripheral blood of occupational n-hexane exposed workers.
Feng ZHU ; Wei-sen ZHANG ; Hui ZUO
Chinese Journal of Industrial Hygiene and Occupational Diseases 2007;25(7):402-403
Adult
;
Female
;
Hematologic Tests
;
Hexanes
;
adverse effects
;
Humans
;
Male
;
Occupational Exposure
;
adverse effects
;
Young Adult
10.Determination of normal reference value of pyrrole adducts in urine in young people in a university in Shandong, China.
Hui WANG ; Yiping WANG ; Zhenwei ZHOU ; Shuo WANG ; Hongyin YIN ; Keqin XIE
Chinese Journal of Industrial Hygiene and Occupational Diseases 2015;33(6):435-437
OBJECTIVETo determine the normal reference value of pyrrole adducts in urine in young people in a university in Shandong, China, and to provide a reliable basis for the clinical diagnosis of n-hexane poisoning.
METHODSA total of 240 college students were randomly selected. After excluding 32 ineligible students, 208 subjects were included in this study, consisting of 104 males and 104 females, with a mean age of 21?3 years (range: 18 to 24 years). Morning urine was collected from each subject. The content of pyrrole adducts was determined by chromatometry.
RESULTSThe content of pyrrole adducts in both male and female obeyed a positively skewed distribution. The median level of pyrrole adducts in male subjects was 0.88 nmol/ml, and the reference value was 0.14-3.92 nmol/ml. The median level of pyrrole adducts in female subjects was 0.93 nmol/ ml, and the reference value was 0.09-3.27 nmol/ml. Student's t test identified no statistical difference in pyrrole adduct level between male and female subjects (t=0.15, P>0.05).
CONCLUSIONThe median level of pyrrole adducts in normal young people is 0.91 nmol/ml, and the reference value is 0.11-3.95 nmol/ml.
Adolescent ; China ; Female ; Hexanes ; poisoning ; Humans ; Male ; Pyrroles ; urine ; Reference Values ; Universities ; Young Adult