1.The effects of hyperbaric oxygen therapy on the survival of dorsal random skin flap: an experimental study in streptozotocin-induced diabetic rats.
Heung Sik PARK ; Yoon Jae CHUNG ; Hong Kyu CHO
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(6):966-977
There have been increasing interests of diabetes in the realm of plastic surgery due to problems like foot ulcer as a complication, delayed wound healing or higher failure rates of flap surgery. Main pathology in diabetes is microvascular compromise as well as metabolic derangements. The disturbance in microvascular circulation results in ischemic environments in the body and acts as a main factor that determines the limit of reconstructive or aesthetic plastic surgery. A useful method to overcome such problems is the use of hyperbaric oxygen therapy, which is known to be effective in the treatment of ischemic skin ulcer or osteoradionecrosis. However, there have been few studies on the survival of diabetic random skin flap or the effects of hyperbaric oxygenation directed to increase survival of such flap. In our study, we supposed that the survival of diabetic random skin flap was diminished owing to compromised microvascular pathology and blood rheology, and metabolic derangements, so we hypothesized that hyperbaric oxygen therapy has both reversible and irreversible effects on the survival of ischemic random skin flap in Streptozotocin-induced diabetic rats. Increase of local transcutaneous oxygen concentration, O2 affinity in blood and dysmorphogenesis of red blood cells are reversible and relatively short-term effects and promotion of neoangiogenesis is irreversible or long-term effects. We intended to confirm that hyperbaric rats and to compare the effects between preoperative and postoperative hyperbaric oxygenation on the survival of such flap. And we expect the additional effects of hyperbaric oxygenation on metabolism in diabetic rat, such as lowering the blood glucose level and solving the arrested weight gain. We divided Streptozotocin-induced diabetic rats into three groups: the first was non-treatment diabetic group, the second was preoperative hyperbaric oxygen treated diabetic group(100% O2, 2 atm, 90min, 15sessions, twice a day), and the third was postoperative hyperbaric oxygen treated group(100% O2, 2atm, 90min, 15sessions, twice a day). After elevation of random skin flap on dorsum of diabetic rats, we evaluated the extent of flap survival by measuring the necrotic areas at 3rd, 7th, 10th, and 13th postoperative days. At that time, we intended to evaluate both effects on flap survival by preoperative and postoperative hyperbaric oxygen therapy. As a result, flap survival of non-treated diabetic group was 41% at 13th postoperative days. In diabetic groups with preoperative and postoperative hyperbaric oxygen therapy, flap survival were increased to 64.6% and 62.4% respectively. Diabetic groups with hyperbaric oxygen therapy have a tendency of meaningful decrement in blood glucose level. However, there were no meaningful differences between preoperative and postoperative hyperbaric oxygen therapy. Hyperbaric oxygen therapy has no effective correlations with body weight changes. We conclude that hyperbaric oxygen therapy has some useful effects on the survival of diabetic random skin flap.
Animals
;
Blood Glucose
;
Body Weight Changes
;
Erythrocytes
;
Foot Ulcer
;
Hyperbaric Oxygenation*
;
Metabolism
;
Osteoradionecrosis
;
Oxygen
;
Pathology
;
Rats*
;
Rheology
;
Skin Ulcer
;
Skin*
;
Surgery, Plastic
;
Weight Gain
;
Wound Healing
2.Pre-and Postoperative Evaluation of Patent Ductus Arteriosus in Children.
In Hee PARK ; Jung Hee LEE ; In Joon SEOL ; Heung Jae LEE
Journal of the Korean Pediatric Society 1985;28(7):683-694
No abstract available.
Child*
;
Ductus Arteriosus, Patent*
;
Humans
3.Analysis of fluid in simple renal cyst.
Heung Jae PARK ; Duck Ki YOON ; Jae Heung CHO ; Sung Kun KOH
Korean Journal of Urology 1991;32(5):725-728
We assessed cyst fluid of 14 cases of simple renal cyst. The aspirates were analyzed for color, lipid. protein, glucose, lactic acid dehydrogenase(LDH), amylase, electrolytes and Papanicolaou smears and cell blocks were performed. A clear amber fluid with minimal lipid content, LDH lower than that of blood and a normal cell pattern on Papanicolaou stain and cell block which are characteristics of transudate were seen in all cases. Although the number of cases are insufficient, it would appear that the content of simple renal cyst is identical to that of transudate.
Amber
;
Amylases
;
Cyst Fluid
;
Electrolytes
;
Exudates and Transudates
;
Glucose
;
Lactic Acid
;
Papanicolaou Test
4.Clinical Value of Prostatic Biopsy in Patients with Elevated Serum PSA.
Jae Hong CHOI ; Heung Jae PARK ; Chil Hun KWON
Korean Journal of Urology 1996;37(10):1110-1116
We analyzed the results of the prostate biopsies of 64 patients with elevated serum PSA (>4ng/ ml) at Kangbuk Samsung Hospital from March 1993 to February 1996. Of 64 patients, 11 patients (17%) had prostate cancer and 53 patients (83%) were diagnosed as benign prostatic hyperplasia. Among the patients with prostate cancer, 1 patient had serum PSA between 4.1 to 10.0ng/ml, 2 patients between 10.1 to 20.0ng/ml and 8 patients above 20ng/ml The detection rates of prostate cancer in each serum PSA levels were 3%, 15% and 36% respectively. Two of 17 patients with both negative DRE and TRUS were diagnosed as prostate cancer Two of 21 patients with positive TRUS and negative DRE had prostate cancer but none of 8 patients with positive DRE and negative TRUS had prostate cancer. Seven of 18 patients with both positive TRUS and DRE had prostate cancer. The sensitivity, specificity, positive predictive value and overall accuracy of DRE and TRUS in patients with elevated PSA (>4ng/m1) were 64%, 64%, 27%, 64% and 82%, 43%, 23%, 50% respectively in patients with elevated serum PSA (>4ng/ml). In conclusion, these results suggest that prostate biopsy in early diagnosis of prostate cancer would be needed for the patients with elevated serum PSA (>4ng/ml) regardless of the results of DRE and TRUS.
Biopsy*
;
Early Diagnosis
;
Humans
;
Prostate
;
Prostate-Specific Antigen
;
Prostatic Hyperplasia
;
Prostatic Neoplasms
;
Sensitivity and Specificity
5.The Antivasospasmic Effect of Arterial Freezing on Acute Damaged Endothelium.
Yoon Jae CHUNG ; Byung Kyu SOHN ; Heung Sik PARK ; Seung Ha PARK
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1999;26(4):696-701
During the microsurgery or during the postoperative period, the occurrence of the vascular spasm increases the failure rate of microvascular anastomosis,and in cases of trauma, the thrombogenic possibility is increased by the endothelial damage. The author thought that the vascular freezing of crushed vessels could improve the patency rate of microvascular anastomosis. Vascular freezing destroys most of the cells in the intima and media. There by causing degeneration of adrenergic fibers. Even though regeneration occurs after 2-3 weeks, regeneration in the smooth muscle layer is still incomplete. So vascular freezing has beneficial effects on relief of vasospasm. Fifteen Sprague-Dawley rats weighing approximately 300 g each were inflicted with crushing injury on the femoral arteries of the right side and the crushing injury with vascular freezing on the femoral arteries of the left side. The gross and histologic findings, as well as the patency rates, were observed at the postoperative 2nd, 10th, and 30th day,and the results were compared between the crushed and crush-freezing groups. The left side (crush-freezing group) showed less vasospasm and less thrombogenesis than the right side (crushed group). There were no significant differences in the patency rate between the crushed group and crush-freezing group. Vascular freezing is suggested to be effective on a potentially thrombogenic, endothelial damaged vessel as a prophylactic treatment method against vasospasm. Clinical application of vascular freezing awaits further experimentation.
Adrenergic Fibers
;
Endothelium*
;
Femoral Artery
;
Freezing*
;
Microsurgery
;
Muscle, Smooth
;
Postoperative Period
;
Rats, Sprague-Dawley
;
Regeneration
;
Spasm
6.The Role K+ channel and the Effect of K+ channel Opener in the Relaxation of Vaginal Smooth Muscle.
Hong Seok PARK ; Heung Jae PARK ; Du Geon MOON ; Je Jong KIM ; Sung Kun KOH
Korean Journal of Urology 2000;41(8):968-975
No abstract available.
Muscle, Smooth*
;
Relaxation*
7.An immunocytochemical study of herpes simplex virus-type II expression in benign prostatic hyperplasia and adenocarcinoma of prostate.
Korean Journal of Urology 1992;33(6):968-973
A laboratory based study was performed to survey possible etiological relationship of herpes virus type II in carcinoma of the prostate. A total of 33 patients (20 with prostatic carcinoma and 13 with benign prostatic hyperplasia as control) who underwent transurethral resection of the prostate was studied. Paraffin embedded prostatic tissue materials were examined by immunocytochemical stain for herpes simplex virus-type II And the grade. stage of tumor and age of patient were recorded for the comparison with herpes simplex virus-type II expression. The results were as follows: 1. The average age of patient with prostatic cancer was 71.6 years +/- 5.2 years (mean+/-S.D.) and of patient with BPH was 67.7 years +/- 6.7 years (mean+/-S.D.). 2. Of the 20 blocks of prostatic carcinoma, 19 cases (95%) showed positive reaction and of the 13 blocks of benign prostatic hyperplasia, only 1 case (7.7%) demonstrated positive reaction to immunocytochemical stain for herpes simplex virus-type II . Antibody prevalence between prostatic cancer and benign prostatic hyperplasia group were significantly different (p<0.005). 3. The incidence of herpes simplex virus-type E antigen did not increase in proportion to grade and stage of prostatic carcinoma. From the above results, it is suggested that the demonstration of specific herpes virus type II antigen in patients with prostatic cancer supports an possible etiologic roles of herpes virus type II But epidemiological studies are recommended to define definite etiologic roles of herpes simplex type II virus in prostatic carcinoma.
Adenocarcinoma*
;
Epidemiologic Studies
;
Herpes Simplex*
;
Humans
;
Incidence
;
Paraffin
;
Prevalence
;
Prostate*
;
Prostatic Hyperplasia*
;
Prostatic Neoplasms
8.Echocardiographic Evaluation of Pulmonary Arterial Hypertension in Pediatric Congenital Heart disease.
Myoung Sung MOON ; In Hee PARK ; Heung Jae LEE ; Hahng LEE ; Keun Soo LEE
Journal of the Korean Pediatric Society 1984;27(10):971-981
No abstract available.
Echocardiography*
;
Heart Defects, Congenital*
;
Hypertension*
9.The three-line sign of epiglottic enlargement on neck lateral radiograph.
Jin Gyoon PARK ; Jae Kyu KIM ; Heung Keun KANG ; Hyon De CHUNG ; Joong Kil LEE
Journal of the Korean Radiological Society 1991;27(3):317-321
No abstract available.
Neck*
10.So-called 'Septal Aneurysm' in membranous Ventricular Septal defect.
Han Young LEE ; In Hee PARK ; Ha Baik LEE ; Heung Jae LEE
Journal of the Korean Pediatric Society 1985;28(9):869-879
No abstract available.
Heart Septal Defects, Ventricular*