No abstract available.
Child* ; Ductus Arteriosus, Patent* ; Humans

There have been increasing interests of diabetes in the realm of plastic surgery due to problems like foot ulcer as a complication, delayed wound healing or higher failure rates of flap surgery. Main pathology in diabetes is microvascular compromise as well as metabolic derangements. The disturbance in microvascular circulation results in ischemic environments in the body and acts as a main factor that determines the limit of reconstructive or aesthetic plastic surgery. A useful method to overcome such problems is the use of hyperbaric oxygen therapy, which is known to be effective in the treatment of ischemic skin ulcer or osteoradionecrosis. However, there have been few studies on the survival of diabetic random skin flap or the effects of hyperbaric oxygenation directed to increase survival of such flap. In our study, we supposed that the survival of diabetic random skin flap was diminished owing to compromised microvascular pathology and blood rheology, and metabolic derangements, so we hypothesized that hyperbaric oxygen therapy has both reversible and irreversible effects on the survival of ischemic random skin flap in Streptozotocin-induced diabetic rats. Increase of local transcutaneous oxygen concentration, O2 affinity in blood and dysmorphogenesis of red blood cells are reversible and relatively short-term effects and promotion of neoangiogenesis is irreversible or long-term effects. We intended to confirm that hyperbaric rats and to compare the effects between preoperative and postoperative hyperbaric oxygenation on the survival of such flap. And we expect the additional effects of hyperbaric oxygenation on metabolism in diabetic rat, such as lowering the blood glucose level and solving the arrested weight gain. We divided Streptozotocin-induced diabetic rats into three groups: the first was non-treatment diabetic group, the second was preoperative hyperbaric oxygen treated diabetic group(100% O2, 2 atm, 90min, 15sessions, twice a day), and the third was postoperative hyperbaric oxygen treated group(100% O2, 2atm, 90min, 15sessions, twice a day). After elevation of random skin flap on dorsum of diabetic rats, we evaluated the extent of flap survival by measuring the necrotic areas at 3rd, 7th, 10th, and 13th postoperative days. At that time, we intended to evaluate both effects on flap survival by preoperative and postoperative hyperbaric oxygen therapy. As a result, flap survival of non-treated diabetic group was 41% at 13th postoperative days. In diabetic groups with preoperative and postoperative hyperbaric oxygen therapy, flap survival were increased to 64.6% and 62.4% respectively. Diabetic groups with hyperbaric oxygen therapy have a tendency of meaningful decrement in blood glucose level. However, there were no meaningful differences between preoperative and postoperative hyperbaric oxygen therapy. Hyperbaric oxygen therapy has no effective correlations with body weight changes. We conclude that hyperbaric oxygen therapy has some useful effects on the survival of diabetic random skin flap.
Animals ; Blood Glucose ; Body Weight Changes ; Erythrocytes ; Foot Ulcer ; Hyperbaric Oxygenation* ; Metabolism ; Osteoradionecrosis ; Oxygen ; Pathology ; Rats* ; Rheology ; Skin Ulcer ; Skin* ; Surgery, Plastic ; Weight Gain ; Wound Healing

We assessed cyst fluid of 14 cases of simple renal cyst. The aspirates were analyzed for color, lipid. protein, glucose, lactic acid dehydrogenase(LDH), amylase, electrolytes and Papanicolaou smears and cell blocks were performed. A clear amber fluid with minimal lipid content, LDH lower than that of blood and a normal cell pattern on Papanicolaou stain and cell block which are characteristics of transudate were seen in all cases. Although the number of cases are insufficient, it would appear that the content of simple renal cyst is identical to that of transudate.
Amber ; Amylases ; Cyst Fluid ; Electrolytes ; Exudates and Transudates ; Glucose ; Lactic Acid ; Papanicolaou Test

We analyzed the results of the prostate biopsies of 64 patients with elevated serum PSA (>4ng/ ml) at Kangbuk Samsung Hospital from March 1993 to February 1996. Of 64 patients, 11 patients (17%) had prostate cancer and 53 patients (83%) were diagnosed as benign prostatic hyperplasia. Among the patients with prostate cancer, 1 patient had serum PSA between 4.1 to 10.0ng/ml, 2 patients between 10.1 to 20.0ng/ml and 8 patients above 20ng/ml The detection rates of prostate cancer in each serum PSA levels were 3%, 15% and 36% respectively. Two of 17 patients with both negative DRE and TRUS were diagnosed as prostate cancer Two of 21 patients with positive TRUS and negative DRE had prostate cancer but none of 8 patients with positive DRE and negative TRUS had prostate cancer. Seven of 18 patients with both positive TRUS and DRE had prostate cancer. The sensitivity, specificity, positive predictive value and overall accuracy of DRE and TRUS in patients with elevated PSA (>4ng/m1) were 64%, 64%, 27%, 64% and 82%, 43%, 23%, 50% respectively in patients with elevated serum PSA (>4ng/ml). In conclusion, these results suggest that prostate biopsy in early diagnosis of prostate cancer would be needed for the patients with elevated serum PSA (>4ng/ml) regardless of the results of DRE and TRUS.
Biopsy* ; Early Diagnosis ; Humans ; Prostate ; Prostate-Specific Antigen ; Prostatic Hyperplasia ; Prostatic Neoplasms ; Sensitivity and Specificity

No abstract available.
Muscle, Smooth* ; Relaxation*

During the microsurgery or during the postoperative period, the occurrence of the vascular spasm increases the failure rate of microvascular anastomosis,and in cases of trauma, the thrombogenic possibility is increased by the endothelial damage. The author thought that the vascular freezing of crushed vessels could improve the patency rate of microvascular anastomosis. Vascular freezing destroys most of the cells in the intima and media. There by causing degeneration of adrenergic fibers. Even though regeneration occurs after 2-3 weeks, regeneration in the smooth muscle layer is still incomplete. So vascular freezing has beneficial effects on relief of vasospasm. Fifteen Sprague-Dawley rats weighing approximately 300 g each were inflicted with crushing injury on the femoral arteries of the right side and the crushing injury with vascular freezing on the femoral arteries of the left side. The gross and histologic findings, as well as the patency rates, were observed at the postoperative 2nd, 10th, and 30th day,and the results were compared between the crushed and crush-freezing groups. The left side (crush-freezing group) showed less vasospasm and less thrombogenesis than the right side (crushed group). There were no significant differences in the patency rate between the crushed group and crush-freezing group. Vascular freezing is suggested to be effective on a potentially thrombogenic, endothelial damaged vessel as a prophylactic treatment method against vasospasm. Clinical application of vascular freezing awaits further experimentation.
Adrenergic Fibers ; Endothelium* ; Femoral Artery ; Freezing* ; Microsurgery ; Muscle, Smooth ; Postoperative Period ; Rats, Sprague-Dawley ; Regeneration ; Spasm

No abstract available.
Heart Septal Defects, Ventricular*

No abstract available.
Echocardiography* ; Heart Defects, Congenital* ; Hypertension*

No abstract available.
Mycobacterium bovis* ; Recurrence* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

Local contributing factors in penile erection are trabecular smooth muscle, endothelium, trabecular fibroelastic components, tunica albuginea and local neuro-control. There are three neuroeffector systems in local neuro-control for penile erection. One is adrenergic system causing contraction and the others are cholinergic and noncholinergic nonadrenergic system causing relaxation of corpus cavernosum under normoxia. The effect of these systems under hypoxic condition however is not fully understood. The aims of this study were to detect the pharmacophysiological changes of corporal smooth muscle about 3 local neuroeffector systems under hypoxia in the rabbit and to apply the results of study to the management of the priapism. The strips of rabbit corporal tissues were studied for isometric tension measurement under normoxia, hypoxia and cooling condition in the organ chambers. Influence of NL- monomethyl-L-arginine (L-NMMA) and L-arginine to acetylcholine under normoxia and effects of phenylephrine, norepinephrine, acetylcholine, VIP, endothelin 1, papaverine and KCI on the rabbit corpus cavernosal tissue were monitored under normoxia and hypoxia and changes under cooling condition were observed. Relaxing effect of acetylcholine under normoxia was suppressed with L-NMMA and this suppression was reversed with L-arginine. Relaxation with acetylcholine and contraction with endothelin 1 were suppressed under hypoxic condition. Contracting effect of norepinephrine and phenylephrine was stronger under hypoxia or cooling condition than normoxia or 37 degrees C condition respectively. Relaxing effect of VIP and papaverine on corpus cavernosa was similar under normoxia or hypoxia. These results suggest that endothelium-dependent relaxation by cholinergic and noncholinergic nonadrenergic system and endothelium-dependent contraction by endothelin 1 are suppressed under hypoxic condition. VIP related noncholinergic nonadrenergic relaxation and direct relaxation effect of papaverine to corporal smooth muscle are preserved under hypoxia. Application of adrenergics and local irrigation with cold saline would be effective in the management of priapism.
Acetylcholine ; Adrenergic Agents ; Anoxia* ; Arginine ; Endothelin-1 ; Endothelium ; Male ; Muscle, Smooth ; Norepinephrine ; omega-N-Methylarginine ; Papaverine ; Penile Erection ; Phenylephrine ; Priapism ; Relaxation