We report a case of hyperkeratosis of the nipple and areola occuing in 33 year old woman. She did not have a history of endocriruipathy, horrnonal therapy and other ceatoses, so this case seems to be the nevoid form by Levy-Franckel classification. Interestingly, however the lesion which had developed before marriage suddenly aggr avated during pregnancy. This may be a unique feature which has not been reported elsewhere. Histapathologic findings are compatible with breviously reported eases. There was no response to topical steroid and retinoic acid treatrnent.
Adult ; Classification ; Female ; Humans ; Marriage ; Nipples* ; Pregnancy* ; Tretinoin

The technique of radial artery cannulation and its complications are well documented, but serious complications are rare. This is a report of one case of amputation of wrist due to finger necrosis developed from the radial artery cannulation in patient who had craniectomy surgery. This 52-year-old 79 kg male underwent subdural hematoma removal surgery. Right radial artery cannulation was carried out percutaneously using 22 gauge Teflon extracath needle after modified Allen's test appeared to be positive. It was intermittently flushed by heparinized solution. His arterial blood pressure was maintained 100/70-110/80 mmHg and 5 units of banked whole blood and 1 unit of fresh frozen plasma were transfused during 8-hours operation. Cannula was removed on the 9th hour after operation because that was obstructed. On the 12th hour after removal of cannula, his right hand noted to be cool and cyanotic. So, warm towel and hot bag applied continuously on the right hand and the right stellate ganglion block was carried out every day for 4 times. However, on the 10th day after removal of cannula, necrotic change of all fingers of the right hand became worse and skin of fingers were shrunken. Therefore, disarticulation of the right wrist carried out on the 71th day of his hospitalization.
Amputation* ; Arterial Pressure ; Catheterization* ; Catheters ; Disarticulation ; Extremities* ; Fingers ; Hand ; Hematoma, Subdural ; Heparin ; Hospitalization ; Humans ; Male ; Middle Aged ; Necrosis ; Needles ; Plasma ; Polytetrafluoroethylene ; Radial Artery* ; Skin ; Stellate Ganglion ; Wrist

Cryptococcosis is a disease caused by the Cryptococcus neoformans, occcuring most frequently in immunocompromised hosts. Cutaneous involvement is seen in 10-15 % of disseminated cases and its manifestation is variable. A 52 year old man presented with a subcutaneous neck mass and severe headache which had lasted for 2 months and 1 month respectively. Initially cutaneous involvement was monomorphic and localized and a CSF study failed to reveal any organisms. After several weeks of herb medication, however, multiple skin lesions occurred with varied morphology and a CSF study confirmed cryptococcosis by culture. The Urine cortisol was markedly elevated, suggesting an exogenous intake of steroid.
Cryptococcosis* ; Cryptococcus neoformans ; Headache ; Humans ; Hydrocortisone ; Immunocompromised Host ; Middle Aged ; Neck ; Skin

No abstract available.

We present a series of 10 Patients(Seven men and three women with an average age of 53 years) who underwent decompressive craniectomy for treatment to massive brain swelling following acute cerebral infarction. Clinical signs of cerebral herniation(anisocoria or fixed and dilated pupil, and/or hemiplegia with decerebrate righidity) were present in all patients. Computed tomography and magnetic resonance imaging showed the mass effect by cerebral edema through midline shift. All patients were treated with an extensive craniectomy and duroplasty. Among them, one recovered without neurological deficit, three were moderately disabled but functionally dependent, three remained in a persistent vegetative state and three died within 9 days after surgery(good recovery=1, moderate disability=3, persistent vegetative state=3, death=3). The results suggest that decompressive craniectomy can be an useful lifesaving procedure for massive cerebral edema following widespread hemispheric infarction.
Brain Edema ; Cerebral Infarction* ; Decompressive Craniectomy* ; Female ; Hemiplegia ; Humans ; Infarction ; Magnetic Resonance Imaging ; Male ; Persistent Vegetative State ; Prognosis ; Pupil

No abstract available.
Female* ; Humans

Our aim was to identify histologic changes in cervical carcinoma tumor cells due to chemotherapy,by electron microscopic examination. Cisplatin and 5-fluorouracil were used between March 1, 1994 and February 28, 1995 on a total of 16 patients. The treatment schedule consisted of 75 mg/m2 cisplatin via iv with hyperhydration on Day 1, in combination with 1000 mg/m2 5-fluorouracil via continuous iv on Day 1 to 5. The treatment was repeated every 4 weeks with a maxinum of 3 courses. Ultrastructurally, chemotherapy induced apoptosis,indicated by condensation of nucleus and cytoplasm,fragmentation of nuclei, and apoptotic bodies. Due to repeat chemotherapy, increased levels of desmosomes were noted and parts of tumor nests were replaced by mature squamous cells. Tumor nests were reduced in size, mitochondria exhibited swelling, the endoplasmic reticulum was dilated, and infiltration of inflammatory cells increased after chemotherapy. These results suggest that chemotherapy induces apoptosis and injury to the cytoplasm and nuclei of tumor cells. However, the exact selection mechanism of the biochemical pathway of cell death is not fuUy understood. Further study of the molecular biologic actions of cell death after chemotherapy is warranted.
Apoptosis ; Appointments and Schedules ; Cell Death ; Cisplatin ; Cytoplasm ; Desmosomes ; Drug Therapy* ; Endoplasmic Reticulum ; Fluorouracil ; Humans ; Mitochondrial Size

No abstract available.
Leiomyoma*

A 53-year-old man had skin-colored linear serpiginous plaque within brownish patch on his left thigh for one year. He habitually drank natural spring water for 3 years. We diagnosed this case as sparganosis infiltrated within dermis by histologic and parasitologic diagnosis. The skin lesion mimicked the cutaneous larva migrans by showing dermal migration of sparganum to pro-duce itchy linear serpiginous plaque. We report an interesting case of sparganosis mimicking cutaneous larva migrans.
Dermis ; Diagnosis ; Humans ; Larva Migrans* ; Middle Aged ; Natural Springs ; Skin ; Sparganosis* ; Sparganum ; Thigh ; Water

Clinical observation was made on 272 cases of urolithiasis who admitted in the department of Urology, Seoul Adventist Hospita1, during the period from Jan. 1976 to Dec. 1980. The results of this observation may be summarized as follows: 1. Among total admissions (969 cases), those with urolithiasis were 272 cases (28.2%) and the sex ratio of male and female was about 9.2 : 5.9. 2. The highest incidence on age distribution showed in 20 to 40 years (61.0%). 3. On seasonal distribution, occurence was prevalent in summer (3O.8%). 4. The ureter was he most favored predilection site of urinary stone (84.9%) and upper urinary stones were almost noted (95.6%). The most common location of ureteral stones was lower third of ureter (60.2%). 5. In the aspect of number of urinary calculi, the single was in 257 cases (91.8%) and the most common size was below 1.0cm in diameter (64.8%), weight in 0.6-1.0gm (38.4%). In shape, round or oval stones were more prevalent (38.9%) and the 2 cases of staghorn calculi were noted in renal region. 6. The clinical symptoms of upper urinary tact showed flank pain in 91.8%, nausea & vomiting: etc. in 57.8%. hematuria in 47.8% but in lower urinary tract, hematuria was in 83.3%, vesica1 irritability in some cases. 7. Microscopic hematuria showed in 88.8% and pyuria in 65.3% Positive urine cultures above ever 100,000 colony/ml were obtained in 158 cases (58.O%) and most common organisms were E. coli (56.8%), staphylococcus aureus (21.5%), Proteus mirabilis (8. 2%). 8. It upper urinary stones, hydronephrosis with or without functional deterioration were detected in 91% on excretory urogram or other X-ray films, Among them, moderate hydronephrosis showed in 34.9% 9. The 142 cases of urolithiasis (58.0%) were treated with surgical intervention. Among them, ureterolithotormy was made in 40.7%. 10. On chemical analysis of urinary calculi (107 cases), calcium phosphate and calcium oxalate in mixed type was most common (39.8%). On the chemical component of urinary calculi, most prevalent types were phosphate stone (72.2%). oxalate stone (61.7%), etc.
Age Distribution ; Calcium ; Calcium Oxalate ; Calculi ; Female ; Flank Pain ; Hematuria ; Humans ; Hydronephrosis ; Incidence ; Male ; Nausea ; Proteus mirabilis ; Pyuria ; Seasons ; Seoul ; Sex Ratio ; Staphylococcus aureus ; Ureter ; Urinary Calculi ; Urinary Tract ; Urolithiasis* ; Urology ; Vomiting ; X-Ray Film