No abstract available.
Extremities* ; Sarcoma*

The purpose of this study was to evaluate the histologic difference that occured after trichloroacetic acid(TCA) chemical peel in an animal model that was pretreated with Tretinoin alone or Tretinoin-based combined pretreatment kit. Eight Hartley white guinea pigs were used in our study. The dorsal skin of the guinea pigs was divided into six equal squares(2x2 cm). Upper two areas of these six were not pretreated, middle two areas were pretreated for 4 weeks with Tretinoin alone and lower two areas were pretreated for 4 weeks with Tretinoin-based combined kit. Each guinea pig underwent chemical peel with 50% TCA. The wounded areas were biopsied at post-peeling 3 weeks and 6 weeks. The histology revealed that those animals pretreated with combined kit healed quicker than the animals pretreated with Tretinoin alone. This study implies that if patients are treated with Tretinoin-based-combined pretreatment kit before undergoing chemical peel, the pretreatment time will be shortened.
Animals ; Guinea Pigs* ; Guinea* ; Humans ; Models, Animal ; Skin ; Tretinoin* ; Wounds and Injuries

No abstract available.
Alkaline Phosphatase* ; Calcium* ; Female ; Humans ; Osteocalcin*

A 21-year-young man had an episode of myalgia and chilling 3 days prior to hospital admission. He had consumed common doses of acetaminophen for one day, and was presented in the sauna room for an hour. On the next morning, he complained of dyspnea and was admitted. He presented in rhabdo-myolysis and acute renal failure with increased up-take in the proximal muscles by (99m)Tc-MPD bone scan. He was treated by hemodialysis and discharged on the twenty-eighth hospital day. Rhabdomyolysis has the variable causes. The causes of this case are two, the first cause is common doses of acetaminophen. But, there is no reports for rhabdomyolysis by common doses of acetaminophen only. However, we should consider that acetaminophen is a contributing factor in this case. The second cause is viral infection. Our patient had myalgia and chilling prior to hospital admission. Heat- stroke is well known cause of rhabdomyolysis. The mechnisms for rhabdomyolysis in this disease are hypovolemia, total body potassium deficit, and increased variable cytokines. Sauna, the last cause of our rhabdomyolysis case may have the same mechanisms with heatstroke. Our case had two causative factors, common doses of acetaminophen and sauna. These factors might be cooperated in our case of rhabdomyolysis and acute renal failure.
Acetaminophen* ; Acute Kidney Injury ; Cytokines ; Dyspnea ; Heat Stroke ; Humans ; Hypovolemia ; Muscles ; Myalgia ; Potassium ; Renal Dialysis ; Rhabdomyolysis* ; Steam Bath* ; Stroke

Down syndrome is a chromosome related desease that shows mental retardation, growth retardation and many other signs such as defects in the face, hands and skin. Down syndrome is very uncommon in dizygotic twins, especially in twins with different sex. This twin's chromosomal analysis shows both twins with trisomy 21, but the parents' chromosomal analysis is normal. A 30 year old infertile woman who became pregnant via ICSI(intracytoplasmic sperm injection) has shown dizygotic twins with different sex to have Down syndrome and therefore it is being reported along with simple documents.
Down Syndrome ; Female ; Hand ; Humans ; Intellectual Disability ; Skin ; Sperm Injections, Intracytoplasmic ; Spermatozoa ; Twins, Dizygotic

No abstract available.
Technetium Tc 99m Medronate*

No abstract available.
Technetium Tc 99m Medronate*

PURPOSE: This study was aimed to investigate the clinical findings and the changes of serum levels of inflammatory cytokines according to the presence of erythematous induration at BCG (Bacillus Calmette-Guerin) site in the children with Kawasaki disease. METHODS: Thirty-one patients with Kawasaki disease were classified into a group with erythematous induration at BCG site (BCG (+), n=14, M: F=11: 3) and a group without skin changes at BCG site (BCG (-), n=17, M: F=12: 5). Levels of various laboratory parameters and cytokines including interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-10 (IL-10) and interferon-gamma (IFN-gamma) were determined four times on admission day, 3-4 days, 2 weeks and 8 weeks after intravenous immunoglobuin injection. RESULTS: The age of onset in BCG (+) group was significantly younger than BCG (-) group (15+/-8 months vs. 31+/-16 months, P<0.05). There were no significant differences in other clinical findings and laboratory parameters except elevated ESR in BCG (-) group. There was no difference in complications of coronary arteries and cardiac function between two groups. The serum levels of IL-2, IL-6 and IL-10 were increased in all patients at the diagnosis, but there were no significant differences between BCG (-) and BCG (-) groups. The serial changes of cytokines did not show any significant differences. CONCLUSION: In Kawasaki disease, BCG site injection seems to develop in younger age and not to be related to the differences of immunologic inflammatory response.
Age of Onset ; Child* ; Coronary Vessels ; Cytokines* ; Diagnosis ; Humans ; Interferon-gamma ; Interleukin-10* ; Interleukin-2 ; Interleukin-6* ; Mucocutaneous Lymph Node Syndrome* ; Mycobacterium bovis* ; Skin

PURPOSE: The aim of our study was to determine the clinical course and the prognosis of pulmonary hypertension (PHT) with bronchopulmonary dysplasia (BPD). METHODS: Two hundred forty infants who were admitted to the neonatal intensive care unit (NICU) of Samsung Medical Center from January 2002 to December 2006 and were diagnosed with BPD were enrolled in this study. We investigated their medical records retrospectively to investigate any difference between BPD with PHT group and BPD without PHT group in clinical characteristics, mortality and morbidity. RESULTS: Nineteen (7.9%) of the 240 patients with BPD developed PHT. The ratio of females to males was 2.8:1. The severity of BPD, the small birth weight for gestational age, the duration of mechanical ventilation and the maximal peak inspiratory pressure were significantly associated with the development of PHT. (P=0.000, P=0.007 and P=0.000, respectively) The mortality was higher in the BPD with PHT group than in the BPD without PHT group. (P= 0.000) BPD with PHT group required longer duration of oxygen therapy and had more rehospitalization for respiratory illness than the others. (P=0.014) More patients were admitted to the pediatric intensive care unit and received mechanical ventilation therapy in the BPD with PHT group. (P=0.001 and P=0.020, respectively) CONCLUSIONS: PHT is one of the causes associated with high mortality and morbidity in BPD patients. Therefore, the physician should be alert to the development of PHT in premature infants with severe BPD, especially if the baby is female, less than 500 g of birth weight, small for gestational age, or supported by mechanical ventilation for a prolonged duration
Birth Weight ; Bronchopulmonary Dysplasia ; Female ; Gestational Age ; Humans ; Hypertension, Pulmonary ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Intensive Care Units ; Intensive Care, Neonatal ; Male ; Medical Records ; Oxygen ; Prognosis ; Respiration, Artificial ; Retrospective Studies

PURPOSE: In patients with the congenitally corrected transposition of great arteries (CCTGA), systemic ventricle tends to be hypertrophic due to longstanding systemic high pressure that may lead to dysfunction of ventricle. The aim of this study was to assess the global and segmental wall function of systemic right ventricle in CCTGA. METHODS: Twelve patients with the CCTGA patients were enrolled. Ejection fraction of systemic right ventricle, myocardial performance index (MPI), strain and strain rate were assessed. RESULTS: The median age was 32.5 years with a range of 4 to 66 years. Ejection fraction (EF) using M-mode and Simpsons method was significantly lower in the CCTGA patients (48.5+/-4.6% and 51.2+/-4.1%, respectively, vs 63.7+/-3.6% and 66.6+/-3.8% respectively). 5 patients had diastolic dysfunction (3/12; pseudo-normalization pattern, 2/12; relaxation abnormality). Strain and strain rate revealed segmental systemic right ventricle dysfunction, and were lower in the CCTGA patients at mid and apical segment of septum and apical segment of anterior wall. The extent of dysfunctional segment was related to the age and MPI. CONCLUSION: There was global dysfunction in the CCTGA patients and it was related with age. Segmental dysfunction was especially shown at mid and apical segment of septum and apical segment of anterior wall and more frequently at apical segment of each wall. The extent of dysfunctional segment was related with age.
Arteries* ; Heart Ventricles ; Humans ; Relaxation ; Transposition of Great Vessels ; Ventricular Function, Right*