No abstract available.
Eczema* ; Herpes Simplex* ; Kaposi Varicelliform Eruption* ; Simplexvirus*

BACKGROUND: Pediatric infectious skin diseases are different from their counterparts in adults, since the sources of infection and disease progressions are distinct. To our knowledge, there have been no reports of epidemiologic studies of pediatric infectious skin diseases in Korea. OBJECTIVE: The purpose of this study was to evaluate the distribution of pediatric infectious skin diseases in the Ansan and Southwestern area of Gyeonggi-do, and to compare the results with previous reports about general pediatric dermatoses. METHODS: The authors retrospectively evaluated 4,366 cases of pediatric infectious skin diseases from July 2003 to June 2013 in the Department of Dermatology at Korea University Ansan Hospital. The monthly, seasonal, and annual incidences, as well as the ages and genders of the patients were evaluated. RESULTS: The study included 2004 (45.0%) girls and 2362 (55.0%) boys. The most frequent age of infection was 4 to 6 years old (range 0~15 years), and the peak incidences occurred in July, August, and January. The most common infectious dermatoses were viral (76.0%), bacterial (11.5%), fungal (8.3%), and parasitic (4.0%). The 10 most common pediatric infectious skin diseases were viral wart (45.8%), molluscum contagiosum (20.9%), impetigo (10.3%), tinea (7.1%), scabies (3.8%), herpes zoster (2.5%), varicella (1.6%), herpes simplex (1.5%), eczema herpeticum (1.1%), and cellulitis (0.9%). CONCLUSION: Compared to previously published reports, the distribution of pediatric infectious skin diseases has changed and was different from general pediatric dermatoses.
Adult ; Cellulitis ; Chickenpox ; Dermatology ; Disease Progression ; Epidemiologic Studies* ; Epidemiology ; Female ; Gyeonggi-do* ; Herpes Simplex ; Herpes Zoster ; Humans ; Impetigo ; Incidence ; Kaposi Varicelliform Eruption ; Korea ; Molluscum Contagiosum ; Retrospective Studies ; Scabies ; Seasons ; Skin Diseases ; Skin Diseases, Infectious* ; Tinea ; Warts

Herpesvirus infections in Cervidae are a serious threat affecting some deer species worldwide. In our attempt to identify malignant catarrhal fever-associated herpesviruses in deer herds, ten gammaherpesviral DNA fragments were identified in five species of deer in herds in China by using a pan-herpesvirus polymerase chain reaction assay targeting viral DNA polymerase. Notably, in sambar (Rusa unicolor), a novel gamma-2 herpesvirus was identified that showed a close relationship with fallow deer lymphotropic herpesvirus (LHV), while the other fragments were phylogenetically grouped together with Elk-LHV. Determination of whether these viruses have any clinical implication in these deer species should be undertaken urgently.
Animals ; Cattle ; China ; Deer ; DNA ; DNA, Viral ; Herpesviridae Infections ; Herpesviridae ; Malignant Catarrh ; Polymerase Chain Reaction

Viruses continue to evolve a new strategy to take advantage of every aspect of host cells in order to maximize their survival. Due to their central roles in transducing a variety of transmembrane signals, GPCRs seem to be a prime target for viruses to pirate for their own use. Incorporation of GPCR functionality into the genome of herpesviruses has been demonstrated to be essential for pathogenesis of many herpesviruses-induced diseases. Here, we introduce US28 of human cytomegalovirus (HCMV) as the best-studied example of virally-encoded GPCRs to manipulate host GPCR signaling. In this review, we wish to summarize a number of US28-related topics including its regulation of host signaling pathways, its constitutive internalization, its structural and functional analysis, its roles in HCMV biology and pathogenesis, its proliferative activities and role in oncogenesis, and pharmacological modulation of its biological activities. This review will aid in our understanding of how pathogenic viruses usurp the host GPCR signaling for successful viral infection. This kind of knowledge will enable us to build a better strategy to control viral infection by normalizing the virally-dysregulated host GPCR signaling.
Biology ; Carcinogenesis ; Cytomegalovirus Infections* ; Cytomegalovirus* ; Genome ; Herpesviridae ; Humans*

A case of herpes simplex autoinoculated on the 1st interdigital web of right hand was reported, Herpes labialis characterized by confluent rice sized vesicular eruptions had developed on the midportion of upper lip. After 3 days, typical herpetic lesion occurred on the 1st interdigital web of right hand. We reviewed briefly the recent literatures.
Hand ; Herpes Labialis ; Herpes Simplex* ; Lip

Valacyclovir is an oral antiviral agent used in the treatment of herpesvirus infection. Although neuropsychiatric symptoms may accompany the use of this drug, valacyclovir is increasingly used to treat herpes zoster, as it is more effective when orally administered. This paper reports one case of neurotoxicity of valacyclovir in patients with end stage renal disease who were undergoing maintenance hemodialysis. Valacyclovir can induce life-threatening neurotoxicity, especially in end stage renal disease patients despite the appropriate dose reduction. Furthermore, Valacyclovir-induced neurotoxicity can be effectively managed by intensive hemodialysis.
Herpes Zoster ; Herpesviridae Infections ; Humans ; Kidney Failure, Chronic ; Renal Dialysis*

No abstract available.
Herpes Genitalis* ; Herpes Simplex* ; Simplexvirus*

Eczema herpeticum is a herpes simplex virus infection with disseminated skin involvement, which superimposes on a pre-existing dermatosis. Two siblings with simultaneous primary herpes simplex virus (HSV) infection on the normal skin of their backs, followed by their mother's herpes labialis. Eczema herpeticum was diagnosed on the basis of history, clinical feature, Tzanck test, histologic examination and a serologic test. Their skin lesions were healed by treatment with oral acyclovir and mupirocin ointment.
Acyclovir ; Eczema* ; Herpes Labialis ; Humans ; Kaposi Varicelliform Eruption* ; Mupirocin ; Serologic Tests ; Siblings* ; Simplexvirus ; Skin Diseases ; Skin*

No abstract available.
Herpes Zoster Ophthalmicus* ; Herpes Zoster*

BACKGROUND: Epstein-Barr virus (EBV) is causative agent of infectious mononucleosis and nasopharyngeal carcinoma and associated with Burkitt lymphoma and other tumors. The recombinant protein is needed for the rapid and sensitive serodiagnosis of EBV infection. METHODS: EBV gene encoding the protein reactive with the sera of EBV-infected patient was cloned and characterized with lambda gt11 expression library of cDNA of EBV B95-8 strain. RESULTS: The recombinant proteins from clone 12, 15 and 21 were expressed as 120, 118, 160 kDa-usion protein with beta-galactosidase, respectively, which were reactive with IgG anti-EBV antibody-positive sera, but not with anti-EBV antibody-negative sera. A homology search of the DNA sequence of the cloned gene with EBV B95-8 sequences revealed that those were located at 61716~62087, 61898~62085, and 102128~103158, respectively. These positions correspond to BFRF3, BFRF3, and BZLF1, respectively, which were reported as immunogenic protein which evoked strong and longstanding antibody response and had no sequence homology with the proteins of other herpesviruses. All the patients' sera were reactive with clone 12 protein, but only 5 out of 9 patients' sera were reactive with clone 21 protein. CONCLUSION: Clone 21 protein expressing BFRF3 fragment was immunoreactive in patient sera from natural EBV infection and was regarded as useful candidate for the serodiagnosis of EBV infection.
Antibody Formation ; Base Sequence ; beta-Galactosidase ; Burkitt Lymphoma ; Clone Cells* ; Cloning, Organism* ; DNA, Complementary ; Epstein-Barr Virus Infections ; Herpesviridae ; Herpesvirus 4, Human* ; Humans ; Immunoglobulin G ; Infectious Mononucleosis ; Recombinant Proteins ; Sequence Homology ; Serologic Tests