1.Disseminated herpes zoster in immunocompetent patients not due to varicella-zoster virus gene mutation.
Zhong-hui SUN ; Yun-yi GUO ; Ming LI ; Zhi-rong YAO
Chinese Medical Journal 2013;126(16):3193-3193
Adult
;
Herpes Zoster
;
etiology
;
Herpesvirus 3, Human
;
genetics
;
Humans
;
Male
;
Middle Aged
;
Mutation
3.Segmental Zoster Paresis:Report of One Case and Literature Review.
Wen Han LI ; Pan ZHANG ; Meng Ting ZHU ; Xiang Yu XU ; Long JIN ; Jian LUO ; Cai Gui LUO ; Jun Hui QIAN
Acta Academiae Medicinae Sinicae 2020;42(6):836-839
Segmental zoster paresis(SZP)is a rare complication in herpes zoster infection,with its symptoms often neglected due to the co-existence of pain.Here we reported a case of SZP.Also,we analyzed 42 Chinese SZP cases in literature,which revealed that the male to female ratio of SZP patients was 13∶8,and the median age of disease onset was 65 years.The most commonly affected region is upper limb.The diagnosis depends mainly on typical medical history and clinical symptoms.Although there is no definite therapy for SZP,the antiviral therapy is the most commonly used treatment,which achieved complete recovery in 78.6% of the patients and partial recovery in 14.3% of the patients.
Aged
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Female
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Herpes Zoster/diagnosis*
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Humans
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Male
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Paresis/etiology*
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Upper Extremity/physiopathology*
4.Case of motor nerve injury after herpes zoster.
Min ZHANG ; Aimei ZHAO ; Shixi HUANG
Chinese Acupuncture & Moxibustion 2015;35(3):282-282
6.Case of perianal herpes zoster complicated with dysuria.
Chinese Acupuncture & Moxibustion 2015;35(9):916-916
Acupuncture Therapy
;
Aged
;
Dysuria
;
etiology
;
physiopathology
;
therapy
;
Herpes Zoster
;
complications
;
virology
;
Herpesvirus 3, Human
;
physiology
;
Humans
;
Male
;
Perineum
;
virology
7.Herpes zoster ophthalmicus and delayed contralateral hemiparesis.
Ki Bum SUNG ; Seung Hyun KIM ; Ju Han KIM ; Kyung Cheon CHUNG ; Myung Ho KIM
Journal of Korean Medical Science 1988;3(2):79-82
Central nervous system is often involved by herpes zoster but it is very rarely seen that contralateral hemiparesis or hemiplegia developed after herpes zoster ophthalmicus. We report a case of herpes zoster ophthalmicus followed by the delayed contralateral hemiparesis. A 33-year-old man developed acute cerebral infarction and resultant right hemiparesis 44 days after herpes zoster ophthalmicus in the left side. Brain CT disclosed hypodense area in the left basal ganglia. Cerebral angiography revealed segmental narrowing of M1 portion of the right middle cerebral artery.
Adult
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Cerebral Angiography
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Cerebral Arteries/pathology
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Cerebral Infarction/*etiology/radiography
;
Dominance, Cerebral
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Hemiplegia/*etiology
;
Herpes Zoster Ophthalmicus/*complications
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Humans
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Male
;
Tomography, X-Ray Computed
;
Vasculitis/etiology
8.Immunogenicity and Safety of a Live Attenuated Zoster Vaccine (ZOSTAVAX(TM)) in Korean Adults.
Won Suk CHOI ; Jung Hyun CHOI ; Jun Yong CHOI ; Joong Sik EOM ; Sang Il KIM ; Hyunjoo PAI ; Kyong Ran PECK ; Jang Wook SOHN ; Hee Jin CHEONG
Journal of Korean Medical Science 2016;31(1):13-17
A live attenuated zoster vaccine (ZOSTAVAX(TM), Merck & Co., Inc.) was approved by the Korea Ministry of Food and Drug Safety in 2009. However, the immunogenicity and safety of the vaccine has not been assessed in Korean population. This is multi-center, open-label, single-arm study performed with 180 healthy Korean adults > or =50 yr of age. The geometric mean titer (GMT) and geometric mean fold rise (GMFR) of varicella zoster virus (VZV) antibodies were measured by glycoprotein enzyme-linked immunosorbent assay (gpELISA) at 4 weeks post-vaccination. Subjects were followed for exposure to varicella or herpes zoster (HZ), the development of any varicella/varicella-like or HZ/HZ-like rashes, and any other clinical adverse experiences (AEs) for 42 days post-vaccination. For the 166 subjects included in the per-protocol population, the GMT at Day 1 was 66.9. At 4 weeks post-vaccination, the GMT for this population was 185.4, with a GMFR of 2.8 (95% CI, 2.5-3.1). Of the 180 subjects vaccinated, 62.8% experienced > or =1 AE, with 53.3% of subjects reporting injection-site AEs. The most frequently reported injection-site AEs were erythema (45.0%) with the majority being mild in intensity. Overall, 44 (24.4%) subjects experienced > or =1 systemic AE, 10 (5.5%) subjects experienced a systemic vaccine-related AE, and 3 (1.7%) subjects experienced > or =1 serious AE not related to vaccine. No subjects reported a VZV-like rash. There was no subject of death and no subject discontinued due to an adverse event. A single dose of zoster vaccine induced VZV-specific gpELISA antibody response and was generally well-tolerated in healthy Korean adults > or =50 yr of age (registry at www.clinicaltrial.gov No. NCT01556451).
Aged
;
Antibodies, Viral/blood
;
Enzyme-Linked Immunosorbent Assay
;
Erythema/etiology
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Female
;
Herpes Zoster/*prevention & control
;
Herpes Zoster Vaccine/adverse effects/*immunology
;
Herpesvirus 3, Human/immunology
;
Humans
;
Male
;
Middle Aged
9.Efficacy of limited-duration spinal cord stimulation for subacute postherpetic neuralgia.
Masako ISEKI ; Yoshihito MORITA ; Yoshitaka NAKAMURA ; Masataka IFUKU ; Shuji KOMATSU
Annals of the Academy of Medicine, Singapore 2009;38(11):1004-1006
Excellent outcomes were achieved with spinal cord stimulation (SCS) for 7 to 10 days on 2 patients who developed postherpetic neuralgia. Both patients were within 2 to 3 months of the onset of the condition, and nerve blocks provided only temporary pain relief and drug therapies had poor efficacy. The authors believe that limited-duration SCS for subacute postherpetic neuralgia is a useful treatment approach that may prevent the pain from progressing to chronic postherpetic neuralgia.
Aged
;
Electric Stimulation Therapy
;
methods
;
Female
;
Herpes Zoster
;
complications
;
Humans
;
Neuralgia, Postherpetic
;
etiology
;
physiopathology
;
therapy
;
Outcome Assessment (Health Care)
;
Pain, Intractable
;
therapy
;
Spinal Cord
;
physiology
10.Clinical Outcome of Treatment with Infliximab in Crohn's Disease: A Single-Center Experience.
Yeon Ju KIM ; Jung Wook KIM ; Chang Kyun LEE ; Hyun Jin PARK ; Jae Jun SHIM ; Jae Young JANG ; Suk Ho DONG ; Hyo Jong KIM ; Byung Ho KIM ; Young Woon CHANG
The Korean Journal of Gastroenterology 2013;61(5):270-278
BACKGROUND/AIMS: Our aim was to assess the long-term data regarding efficacy and safety of infliximab (IFX) treatment for refractory Crohn's disease (CD) patients in our tertiary teaching hospital. METHODS: We have retrospectively analyzed the medical records of 89 CD patients who underwent IFX treatment between March 2003 and February 2011 at Kyung Hee University Hospital (Seoul, Korea). The primary outcome measurements were the rates of initial clinical response (CR) at 10 weeks after the 1st IFX infusion and sustained CR at the end of the follow-up. Overall adverse events related to IFX treatment were also evaluated. RESULTS: The mean (SD) follow-up period of eligible 80 patients was 33.7 (21.9) months. A total of 77 patients (96%) showed initial clinical response, but 8 patients showed loss of response to IFX during the follow-up. Finally, 59 patients (59/77, 76.6%) showed sustained CR at the end of the study. Logistic regression analyses showed that an initial CR at 10 weeks was the independent predictor associated with sustained CR (OR 22.286, 95% CI 2.742-132.717, p=0.001). Overall adverse events reported in 18 patients (18/80, 23.3%), including 3 serious infection (pulmonary tuberculosis and herpes zoster). CONCLUSIONS: Treatment with IFX was efficacious and relatively safe for refractory CD patients in Korea. An initial CR at 10 weeks was significantly associated with sustained CR.
Adult
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Antibodies, Monoclonal/adverse effects/*therapeutic use
;
Crohn Disease/*drug therapy
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Female
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Follow-Up Studies
;
Gastrointestinal Agents/adverse effects/*therapeutic use
;
Herpes Zoster/etiology
;
Humans
;
Logistic Models
;
Male
;
Odds Ratio
;
Retrospective Studies
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Treatment Outcome
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Tuberculosis, Pulmonary/etiology
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Young Adult