1.Clinical presentation and outcomes of Intentional Paraquat Ingestion in a hospital at Northern Philippines from 2011 to 2013
Jose Carlo B. Valencia ; Paul Francis Pua
Philippine Journal of Internal Medicine 2018;56(4):258-263
Introduction:
Acute paraquat (PQ) poisoning is associated with high case fatality rate. Following a report of 108 cases of poisoning from 2011 to 2013, the distribution, sale, and use of PQ was recently prohibited in the Philippines. However, there still is a need to gather additional information on the manifestations of PQ poisoning in the Philippines. Hence, this study aimed to identify the clinical presentation and outcomes of cases of PQ poisoning seen in a hospital at northern Philippines.
Case presentation:
Nine cases of oral PQ poisoning from 2011 to 2013 were included in this series. All cases were intentional. Majority (88%) of the patients were females. Seven of the nine (77%) cases were from Baggao, Cagayan, a nearby agricultural town. Mean age was 30 (range 21-47). Initial presenting symptoms were vomiting, difficulty in swallowing, abdominal pain and gastrointestinal bleeding. Of the nine cases, four died (44%) in the hospital. Three (33%) survived without complications. Long-term outcomes of the remaining two cases (22%) were unknown. All patients who eventually died developed dyspnea during their hospital stay, and subsequently went into acute respiratory failure. Azotemia and leukocytosis were also recorded among those who died.
Discussion:
High mortality rate among PQ poisoning patients can be attributed to the absence of antidote and the unsatisfactory outcomes of post-exposure management.
Conclusion
Mortality rate for this series was 44%, and all died of progressive respiratory failure. Gastrointestinal toxicity was universal in the nine reported cases. Azotemia and leukocytosis were the other significant findings observed among the cases of fatal poisoning
Paraquat
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Herbicides
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Eating
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Poisoning
5.Progress in research on mechanism of pathogenesis and treatment of acute paraquat poisoning.
Yan-jun RUAN ; Xiang-dong JIAN ; Guang-ran GUO
Chinese Journal of Industrial Hygiene and Occupational Diseases 2009;27(2):114-116
Herbicides
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poisoning
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Humans
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Paraquat
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poisoning
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Poisoning
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metabolism
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pathology
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therapy
9.A case of acute poisoning caused by oral administration of large dose hexazinone.
Feng ZHAN ; Wei SONG ; Jun ZHANG ; Ling LIN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2022;40(4):303-305
Hexazinone is a post-emergence herbicide/arboricides, and its acute poisoning has rarely been reported. Hexazinone is low-toxic to humans, but mass intake of hexazinone would still lead to organ impairment. This article analyzes a case of acute hexazinone poisoning from the poisoning treatment center of our hospital, and summarizes the symptoms and treatment effects of hexazinone poisoning, which is aimed at improving the comprehension, diagnosis and treatment of the disease.
Administration, Oral
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Herbicides
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Humans
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Poisoning
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Triazines
10.The research progress of nervous system damage caused by diquat poisoning.
Xiao Ying ZHANG ; Guo Qiang LI ; Bin LIU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2022;40(8):636-640
In recent years, with the withdrawal of paraquat (PQ) pesticides from the market, the number of poisoning cases caused by its substitute diquat (DQ) has shown an increasing trend year by year. Among the clinical manifestations of DQ poisoning, the damage to the central nervous system is relatively common and serious, but the specific toxicity mechanism is not clear, and there is no clear treatment. This article reviews the nervous system damage caused by DQ poisoning in order to improve the understanding systen of DQ poisoning.
Diquat
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Herbicides
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Humans
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Nervous System
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Paraquat
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Poisoning
Result Analysis
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