Objective:To observe the affection of angiotensin Ⅱ antagonists on the cultured subtype 2 receptor of angiotensin II transfected aortic vascular smooth muscle cells of rat.Methods:After transfected the plasmid that contained the cDNA of subtype 2 receptor of angiotensin II into cultured rat vascular smooth muscle cells, the cells were divided into three groups：cells of group 1 were treated with angiotensinⅡ,cells of group 2 were treated with angiotensinⅡand losartan,cells of group 3 were treated with angiotensinⅡ and PD123319 .After experiments，the expression of PCNA, NOS and the cell number was tested, respectively.Results：After treated with Losartan，the cell number of group 2 was(4.17±0.15)×105，the OD value of PCNA was 0.202 6±0.007 6，both of which were less than that of cells of group 3；the OD value of NOS of cells was more in group 2(0.027 5±0.002 1 ) than that in group 3 (0.016 9±0.002 0) (P＜0.01).Conclusions:It suggests that when being activated,subtype 2 receptor of angiotensin Ⅱ could inhibit the proliferation of vascular smooth muscle cells and antagonist the effect of subtype 1 receptor of angiotensin Ⅱ,such an effect may be related to the activation of NOS.

Objective:To compare amony ceftriazone, penicillin, and ciprofluxacin in the treatment of lower respiratory tract infection. 　Methods:Cost-effectiveness was comparitively analysed by using the principle of pharmacoeconomics with ceftriazone, penicillin, and ciprofluxacin in the treatment of lower respiratory tract infection. 　Results:Three drugs in the treatment of lower respiratory trace infection, while cost of penicillin was the lowest.　Conclusion:Penicillin is a first selective drugs for lower respiratory tract infection.

Objective:To explore the combined treatment rigimen of gonococcal prostatitis.　Methods:The combined treament of improving remedy of antibiotics was used by taking orally the Chinese medicine and herb medicine demibain in 54 cases of patient with gonococcal prostatitis. compared with controlled group.　Results:The curing rate of combined treatment group was 74.1%, being higher significantly than that of controlled group (P＜0.05).　Conclusion:The combined treatment is better than the controlled group in curing gonococcal prostatitis and preventing recurrence.

Objective: To improve on the theories of pharm aceutics.　Methods: Explore the research methodology, pers pectives and direction of the pharmaceutical preparations.　Results: The DDS has many advantages and great potential for development.　Conclusion: Numerous new pharmaceutical preparations will be developed in the near future. The potential of the modern pharmaceutical prepar ations is immeasurable.

Objective: To reveal if the use of antimicrobi als is rational in the authors hospital.　Methods: 1 025 cases were investigated retrospectively by systematic sampling from all the inp atients of the year 1997.　Results: 77.8% of the subjects were treated with antimicrobials, of whom, 55.2% treated with 2 or more antimicr obials. Yet only 39 cases had microbiological test before the administration of antimicrobials.　Conclusion: Inappropriate use of antimicr obials exists in the hospital. The management of the use of antimicrobials and c ontinuing education of medical doctors should be enhanced so as to make the use of antimicrobials more rational.

Pleurodesis was pioneered by Spengler in 1906. It was initially used for treating recurrent spontaneous pneumothorax, and then extended to treatment of refractory pneumothorax, malignant pleural effusion and benign hydrothorax. The current trend is that the use of fibroptic bronchoscopy is getting more and more popular than that of thoracoscopy in the practice of internal medicine, and that the application of surgical symphysis and video-assisted thoracoscopy are getting more and more frequently and extensively in surgery. It is envisioned that this trend will continue in the 1st half of 21st century.

Objective:This paper was designed to reveal the active ingredients to inhibit platelet aggregation in Andregraphis Paniculata Ness (APN).　Methods:Separating the active component parts of APN on the antiplatelet aggretion by extraction of organic solvent, chemical separation and silica column chromatography step by step, simultaneously comparing the effect of samples in APN on the antiplatelet aggretion induced by ADP, so that we can find the more active components.　Results:We find the acid components in chlorlform parts (F021) show more active on the antiplatelet aggretion, farthermore we think we can obstain pure chemicals on the antiplatelet aggretion in F0212 and F0214.　Conclusions:The active components on antiplatelet aggretion of APN can be prepared by separation step by step.

Percutaneous transluminal coronary angioplasty (PTCA) is one of the effective interventions for treating atheroclerotic corona ry heart disease. However, myocardial ischemia caused by balloon dilation during the operation has raised great concern. As a result, administration of drugs an d mechanical measures have been employed perioperatively to protect the cardiac muscle so as to prevent or reduce the myocardial ischemia and ensure the safety of the operation. This paper reviews the significance and methodology of pharmac ological myocardial protection during PTCA.

Objective: To observe the stability of tinidaz ole mixed with cefradin in glucose injection under room temperature or 37 ℃ for 8 hours.　Methods:Concentrations of tinidazole and cefrad in were determined by ultraviolet spectrophotometry and pH by a pH meter.　Results: The concentrations of tinidazole and cefradin and the pH of the solution did not change significantly under room temperature and 37 ℃ for 8 hours.　Conclusions: Tinidazole can be mixed with c efradin in glucose injection for clinical use under room temperature or 37 ℃.

Objective: To observe the efficacy of azithromycin in treating the bacterial infectious diseases.　Methods: Intravenous administration of azithromycin was carried out in 40 cases.　Results: The clinical cure rate and eradication rate were 85.0% and 84.8%, respectively. Drug sensitivity tests showed that more isolates were sensitive to azithromycin (87.9%) than to erythromycin (42.4%). The MIC of azithromycin was lower than that of erythromycin. In addition, the adverse effects occurred with low frequency and were usually mild.　Conclusion: Azithromycin is effective and safe in treating bacterial infectious diseases.