Objective To investigate the imaging features of solitary plasmacytoma of bone(SPB),to improve the ability of imaging diagnosis of SPB.Methods Retrospective analysis by surgery or biopsy pathology confirmed 16 cases of patients with SPB clinical and imaging data.Results All lesions were single.X-ray and CT scan showed swelling bone destruction,boundary more clearly,in all cases no periosteal reaction.Compared with the muscle signal,T1-weighted images showed equal or slightly lower signal,T2-weighted images showed high signal.All patients had no significant peritumoral edema in the bone marrow,but were seen varying degrees of soft tissue invasion.Enhanced MR scan,most cases showed significantly enhanced uniformity.Conclusions SPB presents osteolytic destruction,expansive growth and soft tissue mass without bone reaction and peritumoral edema.X-ray,CT and MR together might improve the diagnostic accuracy of SPB.

Epidermal growth factor receptor ( EGFR) express highly or mutant in esophageal cancer,which causing tumor resistance to radiotherapy and leading to poor radiotherapeutic effects.Treatment with antiEGFR can get radiosensitization.There are three main types of molecular targeted research for EGFR:synthetic monoclonal antibody,small molecule tyrosine kinase inhibitors,and other.strategies modulating EGFR biosynthesis based on RNA interference.

Objective:To explore the therapeutic effect of intra-aortic balloon counterpulsation (IABP)on acute my-ocardial infarction (AMI)complicated pump failure.Methods:Clinical data of 82 AMI patients complicated pump failure,which received emergency percutaneous coronary intervention (PCI)in our hospital from Jan 2010 to Oct 2013,were retrospectively analyzed.The patients were divided into IABP group (n=42,received PCI with auxiliary IABP)and routine PCI group (n=40,only received routine PCI therapy).Success rate of treatment,mortality,he-modynamic conditions [systolic blood pressure (SBP),diastolic blood pressure (DBP)and heart rate (HR)]stable to PCI time,length of hospital stay and complications were compared between two groups.Results:Compared with routine PCI group after treatment,there were significant rise in blood pressure [SBP: (80.3± 16.2)mmHg vs. (88.4±12.5)mmHg,DBP:(55.4±10.2)mmHg vs.(60.0±10.5)mmHg]and urine volume [(30.2±8.3)ml/h vs.(40.3±9.4)ml/h],and significant reduction in HR [(92.4±26.1)times/min vs.(80.5±18.5)times/min] in IABP group,P <0.05~<0.01;there was significant increase in success rate (72.5% vs.83.3%),and signifi-cant decrease in mortality rate (27.5% vs.16.7%),time stable to PCI for hemodynamical condition [(10.1±8.1) h vs.(5.0±2.5)h]and length of hospital stay [(18.4±6.2)d vs.(13.5±4.2)d]in IABP group,P <0.05 all;incidence rate of complications was no significant difference between groups (P >0.05).Conclusion:IABP adjuvant treatment helps to raise success rate of PCI,improve hemodynamic condition and increase urine volume,shorten length of hospital stay in patients with AMI complicated pump failure.

0.05).The total treatment costs were(1084.43?247.38)yuan for the treatment group and(1211.23?275.95)yuan for the controlled group,which had significant difference(P0.05).The total costs were(1270.45?218.12)yuan for the treatment group and(1407.51?51.01)yuan for the controlled group(P

Objective To investigate the causes and the clinical significance of the female lower urinary tract symptoms (LUTS). Methods Of the 72 female patients (mean age,48 years;range,8 to 86 years) with LUTS,46 had dysuria,14 with incontinence,10 with frequency and urgency of micturition and 2 with nocturnal enuresis.Urodynamic examinations were conducted in these patients. Results Among the 46 cases with difficulty of urination,whose bladder volumes were 60 to 800 ml,20 had the bladder detrusor contractility of 0,and 26,of 9 to 160 cm H 2O.Linearised passive urethral resistance relation (Linp-URR) figure showed at least grade Ⅲ obstruction in 19 cases.The urethral pressure profiles (UPPs) were 25 to 130 cm H 2O.Dyssynergia of detrusor-external sphincter occurred in 33 cases with voiding dysfunction.Ten cases with frequency of micturition had bladder volume of 97 to 450 ml.Two cases had the bladder detrusor contractility of 0,the other 8 cases were of 9 to 160 cm H 2O.Linp-URR figure showed at least grade Ⅲ obstruction in 2 cases.One case with urgent incontinence had hyper-sensitive bladder.The abdominal leak point pressures were 44 to 76 cm H 2O in 6 cases of stress incontinence.3 cases of overflowing urinary incontinence had no contraction of bladder detrusor and the UPPs were 32 to 42 cm H 2O.The UPPs were 0 to 16 cm H 2O in the 4 cases of total urinary incontinence.Two cases of nocturnal enuresis had detrusor instability with impaired contractility. Conclusions Urodynamic examination is necessary to the diagnosis of female LUTS and it also has significant value in predicting the treatment and prognosis of LUTS.

Objective To evaluate the efficacy of Cobalt 60 radiotherapy in patients with stage I and II non small cell lung cancer. Methods From March 1977 to December 1992, 63 patients with stage I and II non small cell lung cancer were treated. According to the 1997 UICC staging system, 7 patients had stage IA disease, 10 stage IB, 5 stage IIA, and 41 stage IIB. Forty nine patients were confirmed by histopathology, and 14 cases by cytopathology. Fifty eight patients had squamous cell carcinoma, 3 adenocarcinoma, and 2 mixed squamous cell and adenocarcinama. All patients were treated by Cobalt 60. Patients would receive 40 Gy plus a boost of 15～30 Gy. The total dose was D T55～70 Gy in 6～12 weeks. All patients were followed for more than five years. Results The overall 5 year survival for all patients was 17.5%. Fifty eight (92%) patients have died and 11 survived. For the 58 succumbed patients, 52 (90%) died of tumor, and 26 (45%) of them from local failure. Four patients (7%) died of other causes. Conclusion Radiotherapy is an effective treatment option for non small cell lung cancer.

Objective To investigate the effect and psychological intervention of compound polyethylene glycol electrolyte powder in preoperative bowel preparation for gynecologic tumor patients. Methods According to the different drugs,nursing interventions will be January 2015 to March 2017 in third affiliated hospital of Tianjin medical university for surgical treatment of gynecological cancer patients 80 cases groups:control group with routine nursing intervention observation group with mannitol, psychological nursing and compound polyethylene glycol electrolyte with intervention;observation of two groups of patients improve psychological status and intestinal cleaning and the incidence of adverse reactions,the strict record related data and make comparative analysis. Results The psychological nursing and compound polyethylene glycol electrolyte powder(observation group)intervention in patients with gynecologic tumor significantly,the psychological state of patients with improvement than the control group,the bowel cleaning is better than the control group,the difference was statistically significant(P<0.05);two patients with adverse reaction rate comparison,the difference was not statistically significant. Conclusion The preparation of intestinal tract tumor patients before gynecologic selection of psychological nursing and intervention effect of polyethylene glycol electrolyte powder can significantly improve the psychological state,full bowel cleansing patients with high effective rate,and will not increase the adverse reactions,and is worthy of clinical application.

Objective To explore whether glycyrrhizin has protective effect on acute liver injury in mice by NF‐κB signaling pathway .Methods Totally 200 Kunming mice which the body weight were about 29 -30 g were chose and divided into 4 groups randomly ,50 cases in each group .The first group was the control group;the second group was acute liver injury group induced by CCl4 ;the third group was injected with Stronger Neo‐Minophagen C(SNMC) injection on the basis of second groups;the fourth group was treated with NF‐κB inhibitor (proDTC) on the basis of the third group .After 1 ,3 ,5 d treatment ,the serum expressing levels of ALT ,AST ,total bilirubin ,albumin of mice and prothrombin time were detected ,the Child‐Pugh score was calculated ,and the pathological observation was performed .Results The results showed that ,compared to the first group ,after CCl4 treatment ,the expressing levels of AST ,ALT ,total bilirubin and albumin ,the PT and Child Pugh score all were significantly increased(P<0 .05) , which indicated that the acute liver injury model induced by CCl4 was successfully established .After the treatment of SNMT (CCl4 +SNMT) in mice ,although the level of each index did not return to normal level ,with the extension of treatment time ,the level of each index was also significantly reduced (P<0 .05) .At the same time ,this effect could be reversed by NF‐κB inhibitor proDTC .Conclusion SNMT plays a significantly protective role in acute liver injury via regulating NF‐κB signaling pathway .

Objective To investigate the clinical and pathological features of primary hepaticepithelioid hemangio endothelioma (EHE) and try to improve the understanding and diagnosis of this disease.Methods From January 2007 to January 2013,the data of 17 patients with hepatic EHE were retrospectively analyzed,which included clinical,pathological and radiological characteristics,treatment and survival condition of these patients.Results Among 17 cases of hepatic EHE,there were 11 female and six male with the mean age of 46.2 years.Seven patients had right upper quadrant pain of dull pain in liver and the left 10 cases were without any symptoms.The liver function of most patients (15 cases) was normal.The admission diagnosis was mostly misdiagnosed as hepatocellular carcinoma (metastatic liver carcinoma six cases,primary liver carcinoma four cases).Extrahepatic metastasis was found in three patients before operation.The major lesion of the tumor was multiple nodules (10 cases) and most of which were under liver capsule.Retraction of the liver capsule was found in the imaging examination.The features of pathology were intracellular lumen and vacuoles formed in small cells,in which single or couple red blood cells could be found.Nuclear deviation was found in single tumor cell which looked like signet ring cells.The results of immunohistochemistry indicated the positive rate of factor vimentin (4/5) antigen and CD34 (15/17) was high.Surgical resection (14 cases) was the main treatment of hepatic EHE.Fourteen patients were still alive followed up for two to 72 months after operation.Conclusions The incidence of hepatic EHE is low,and it was susceptible to middle aged women and without obvious symptom.No obvious abnormality is found in laboratory examination.Surgical resection is the main treatment which enabled a good prognosis.

BACKGROUND:Intracranial and extracranial arterial stent implantation is the main therapy for cerebrovascular diseases, especialy for some patients who cannot tolerate surgical operation, but the postoperative rehabilitation and biocompatibility problems restrict the further development of the technology. OBJECTIVE:To explore the rehabilitation efficacy and biocompatibility of acupuncture after degradable cerebrovascular stent implantation. METHODS: A total of 70 patients with cerebral arterial stenosis aged 43-79 years were enroled, including 41 males and 29 females, who were al treated with drug-eluting stent implantation, carotid artery stent implantation in 31 cases, vertebral artery stent implantation in 21 cases, subclavian stent implantation in 5 cases, and middle cerebral artery stent implantation in 13 cases. After stent implantation, al the patients were randomly divided into two groups: control group with routine rehabilitation therapy and acupuncture group with routine rehabilitation therapy+electroacupuncture. After 3 months of treamtnet, neurologic impairment scores, Fugl-Meyer score for motor function, Barthel index, degree of stent stenosis, thromboxane A2, prostacyclin, thromboxane A2/ prostacyclin levels were detected. RESULTS AND CONCLUSION:At 3 months after treatment, the neurological impairment scores were significantly lower in the acupuncture group than the control group (P < 0.05), but the Fugl-Meyer score for motor function andBarthel index were higher in the control group (P < 0.05). After treatment, the thromboxane A2 and thromboxane A2/prostacyclin levels were significantly decreased in the two groups (P < 0.05), but the prostacyclin levels were increased than those before treatment (P < 0.05). In addition, there were no differences in the thromboxane A2, prostacyclin, thromboxane A2/prostacyclin levels between the two groups. Compared with the control group, the rate of restenosis was significantly lower in the acupuncture group (P < 0.05), and there were no significant difference in the reference vessel diameter, blood vessel stent diameter, decreased vessel diameter index, re-intervention rate between the two groups (P > 0.05). Taken together, acupuncture can promote the rehabilitation efficacy folowing degradable cerebrovascular stent implantation, reduce the incidence of restenosis, and show good biocompatibility.