No abstract available.
Hepatoblastoma*

Hepatoblastoma (HB) is a rare pediatric malignant tumor of the liver. Most of these tumors arise in the embryo and this is usually discernible in the first 3 years of life; thus, its occurrence in the adult population seems to be unusual. We present this case due to its rarity and its potential to mimic other primary liver tumors in adults such as HCC. To the best of our knowledge with literature review, there are only 40 cases of adult HB reported worldwide. In this paper, we report a case of a 49-year-old female, diagnosed with Chronic Hepatitis B, admitted due to abdominal pain. Physical examination revealed hepatomegaly. Liver function test was unremarkable. AFP was elevated at >50,000ng/mI. Triphasic CT scan revealed a hypodense mass in the right lobe of the liver measuring approximately 11 × 11 × 13cm suggestive of HCC. Subsequently, patient underwent right hepatectomy. Pathological examination, however, demonstrated that the tumor showed a malignant neoplasm with epithelial and mesenchymal components consistent with adult HB, mixed type. Since treatment of adult HB is not yet established, studies have suggested that it is logical to follow the treatment protocol for childhood HB. Hence, this patient underwent chemotherapy with Cisplatin, Vincristine and 5-Fluorouracil. The low incidence of HB in adults presents a diagnostic challenge, requiring a high index of suspicion and a thorough evaluation. Since prognosis could be improved with early detection and treatment, it is important for clinicians not to overlook HB.
Hepatoblastoma ; Hepatomegaly

No abstract available.
Hemorrhage* ; Hepatoblastoma* ; Rupture*

Sialoblastoma and hepatoblastoma of neonate were very rare cancer. We present a case of concurrent sialoblastoma with hepatoblastoma associated with chromosomal anomaly.
Hepatoblastoma* ; Humans ; Infant, Newborn*

A case of hepatoblastoma, disgnosed with biopsy in a two-year-old male is reported with a short review of the literature.
Biopsy ; Hepatoblastoma* ; Humans ; Male

No abstract available.
Hepatoblastoma* ; Puberty, Precocious*

BACKGROUND/AIMS: The status of tumor suppression gene can be assessed indirectly by analyzing the loss of heterozygosity. Hepatoblastoma is a malignant liver tumor in childhood. To find the molecular carcinogenetic mechanism of hepatoblastoma, loss of heterozygosity (LOH) of p73, APC and p53 was studied. MATERIALS AND METHODS: Hepatoblastoma tissues from thirty-three cases were collected by lobectomy or tumorectomy. On H- stained sections, normal and tumor cells were microdissected separately and LOH analysis was perfomed using 8 markers: six of p73, one of APC and one of p53. RESULTS: Number of cases showing at least one LOH in six p73 markers was four out of twenty- six (15.4%): each LOH frequencies in D1S160, D1S170, D1S199, D1S228, D1S243 and D1S253 were in order of 7.7%, 0%, 9.1%, 0%, 12.5% and 0%. LOH frequency of APC was 41.7% and that of p53 was 13.3%. CONCLUSION: Low LOH frequency of p73 related markers indicates that p73 gene may not be implicated in carcinogenesis of hepatoblastoma.
Carcinogenesis ; Hepatoblastoma* ; Liver ; Loss of Heterozygosity*

Familial adenomatous polyposis and hepatoblastoma are rare conditions; the latter is closely related to the FAP gene. We describe the imaging findings of hepatoblastoma in a patient with polyposis coli.
Adenomatous Polyposis Coli* ; Colonic Neoplasms ; Hepatoblastoma* ; Humans

It has been widely accepted that complete surgical resection of hepatoblastoma is essential for long-term survival. But unfortunately less that 50% of hepatic tumors in children can be totally removed at the time of diagnosis. This report is to present the experience of successful resection of hepatoblastoma after concurrent radiotherapy with transarterial chemoinfusion in a child. We believe this modality of treatment enables complete resection of unresectable hepatoblastoma, which is resistant to the systemic chemotherapy.
Child ; Diagnosis ; Drug Therapy ; Hepatoblastoma* ; Humans ; Radiotherapy*

No abstract available.
Carcinoma, Hepatocellular* ; Cell Line* ; Hepatoblastoma* ; Humans*